TC11 - ≥98% , CAS No.100823-03-8

CAS: 100823-03-8 Cat. No.: T413516 Formule: C₂₀H₂₂N₂O₂ Poids moléculaire: 322.40 PubChem CID: 1235479

GRADE & PURITY ≥98%

Synonyms

TC11 | CS-0105753 | 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione | HY-129478 | SCHEMBL2818285 | 5-Amino-2-(2,6-diisopropyl-phenyl)-isoindole-1,3-dione | AKOS040759656 | BS-47334 | 2-(2,6-diisopropylphenyl)-5-amino-1h-isoindole-1,3-dione | 1H-I

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Information

TC11 (CLT-003) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disruption of tubulin polymerization leading to mitotic arrest and promotes degradation of anti-apoptotic protein, MCL1, by sustained CDK1 activation.

Specifications

Synonymes

TC11 | CS-0105753 | 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione | HY-129478 | SCHEMBL2818285 | 5-Amino-2-(2,6-diisopropyl-phenyl)-isoindole-1,3-dione | AKOS040759656 | BS-47334 | 2-(2,6-diisopropylphenyl)-5-amino-1h-isoindole-1,3-dione | 1H-I

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

TC11 (CLT-003) is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9. TC11 shows in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice. TC11 induces disrupt

Conditions de stockage de stockage

Protected from light,Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥98%

Noms et identifiants

• Pubchem Sid: 528767369
• Sourires canoniques: CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N
• IUPAC Name: 5-amino-2-[2,6-di(propan-2-yl)phenyl]isoindole-1,3-dione
• InChIKey: NRPIRIUWEKTNGQ-UHFFFAOYSA-N
• INCHI: 1S/C20H22N2O2/c1-11(2)14-6-5-7-15(12(3)4)18(14)22-19(23)16-9-8-13(21)10-17(16)20(22)24/h5-12H,21H2,1-4H3
• Isomères SMILES: CC(C)C1=C(C(=CC=C1)C(C)C)N2C(=O)C3=C(C2=O)C=C(C=C3)N
• PubChem CID: 1235479
• Poids moléculaire: 322.40

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Isoindoles and derivatives
      • Subclass Isoindolines
        • Level5 Isoindolones
          • Level6 Phthalimides

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Isoindoles and derivatives
• Subclass: Isoindolines
• Intermediate Tree Nodes: Isoindolones
• Direct Parent: Phthalimides
• Alternative Parents: Phenylpropanes Isoindoles Cumenes N-substituted carboxylic acid imides Amino acids and derivatives Azacyclic compounds Primary amines Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Phthalimide - Cumene - Isoindole - Phenylpropane - Monocyclic benzene moiety - Benzenoid - Carboxylic acid imide, n-substituted - Carboxylic acid imide - Amino acid or derivatives - Carboxylic acid derivative - Azacycle - Amine - Organonitrogen compound - Organooxygen compound - Primary amine - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
• Description: This compound belongs to the class of organic compounds known as phthalimides. These are aromatic heterocyclic compounds containing a 1,3-dioxoisoindoline moiety. They are imide derivatives of phthalic anhydrides.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

ANPEP Tchem Aminopeptidase N (863 Activities)

Discover Target: ANPEP

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DU-145 (51482 Activities)

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HL-60 (67320 Activities)

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PC-3 (62116 Activities)

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WI-38 (2654 Activities)

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HUVEC (11049 Activities)

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MDA-MB-231 (73002 Activities)

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Cibles associées (non humaines)

DPP4 Dipeptidyl peptidase IV (11 Activities)

Discover Target: DPP4

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Sus scrofa (849 Activities)

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Mécanismes d'action

Propriétés chimiques et physiques

• Sensibilité: Light sensitive
• Poids moléculaire: 322.400 g/mol
• XLogP3: 4.500
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 322.168 Da
• Monoisotopic Mass: 322.168 Da
• Topological Polar Surface Area: 63.400 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 486.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1