terevalefim - Moligand™, ≥97% , Hepatocyte growth factor receptor agonist, CAS No.1070881-42-3, Hepatocyte growth factor receptor agonist

CAS: 1070881-42-3 Cat. No.: T614382 Formule: C₉H₈N₂S Poids moléculaire: 176.24 PubChem CID: 5714038

GRADE & PURITY Moligand™, ≥97%

Synonyms

(E)-3-(2-(thiophen-2-yl)vinyl)-1H-pyrazole | 3-[2-(2-thienyl)ethenyl]-1H-Pyrazole | SNV-003 | (e)-5-(2-(thiophen-2-yl)vinyl)-1h-pyrazole | 5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole | Refanalin | AB09733 | AKOS040755926 | Terevalefim [USAN:INN] | Terevale

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor

Specifications

Synonymes

(E)-3-(2-(thiophen-2-yl)vinyl)-1H-pyrazole | 3-[2-(2-thienyl)ethenyl]-1H-Pyrazole | SNV-003 | (e)-5-(2-(thiophen-2-yl)vinyl)-1h-pyrazole | 5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole | Refanalin | AB09733 | AKOS040755926 | Terevalefim [USAN:INN] | Terevale

Spécifications et pureté

Moligand™, ≥97%

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

ACTIVATOR, AGONIST

Mécanisme d'action

Hepatocyte growth factor receptor agonist

Pureté

≥97%

Propriétés du produit

• ALogP: 2.2

Noms et identifiants

• Pubchem Sid: 528768756
• Sourires canoniques: c1csc(c1)/C=C/c1ccn[nH]1
• IUPAC Name: 5-[(E)-2-thiophen-2-ylethenyl]-1H-pyrazole
• InChIKey: FOHWAQGURRYJFK-ONEGZZNKSA-N
• INCHI: 1S/C9H8N2S/c1-2-9(12-7-1)4-3-8-5-6-10-11-8/h1-7H,(H,10,11)/b4-3+
• Isomères SMILES: C1=CSC(=C1)/C=C/C2=CC=NN2
• CAS alternatif: 500128-99-4
• PubChem CID: 5714038
• Poids moléculaire: 176.24

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Classe Azoles
      • Subclass Pyrazoles

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Classe: Azoles
• Subclass: Pyrazoles
• Intermediate Tree Nodes: Not available
• Direct Parent: Pyrazoles
• Alternative Parents: Thiophenes Heteroaromatic compounds Azacyclic compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Heteroaromatic compound - Thiophene - Pyrazole - Azacycle - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as pyrazoles. These are compounds containing a pyrazole ring, which is a five-member aromatic ring with two nitrogen atoms (at positions 1 and 2) and three carbon atoms.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Cibles associées (humaines)

MET Tclin Hepatocyte growth factor receptor (0 Activities)

Discover Target: MET

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propriétés chimiques et physiques

• Poids moléculaire: 176.240 g/mol
• XLogP3: 2.200
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 176.041 Da
• Monoisotopic Mass: 176.041 Da
• Topological Polar Surface Area: 56.900 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 170.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 1
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 1
• Covalently-Bonded Unit Count: 1