10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
TH34 is aHDACinhibitor that shows pronounced selectivity for HDACs 6, 8 and 10 over HDACs 1, 2 and 3. In a NanoBRET assay, TH34 strongly binds HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM).
Targets
HDAC8 ; HDAC6 ; HDAC10 1.9 μM; 4.6 μM; 7.7 μM
In vitro
TH34 strongly binds to HDAC6, 8 and 10 with low-micromolar IC50 concentrations (HDAC6: 4.6 µM, HDAC8: 1.9 µM, HDAC10: 7.7 µM), and shows no substantial affinity to HDAC2 at concentrations up to 50 µM. Its treatment induces hyperacetylation of tubulin and SMC3. TH34 effectively and selectively eliminates high-grade neuroblastoma cells while sparing non-transformed human cells. In neuroblastoma cell lines as well as primary neuroblastoma cells, it markedly induces DNA damage, followed by differentiation and G2/M phase cell cycle arrest at later timepoints, eventually leading to cell death.
Cell Research(from reference)
Cell lines：SK-N-BE(2)-C cells
Concentrations：10 μM
Incubation Time：48 h
| ALogP | 2.723 |
|---|---|
| Nombre de HBD | 2 |
| Liaison rotative | 4 |
| Pubchem Sid | 528767397 |
|---|---|
| Sourires canoniques | CC1=C(C=C(C=C1)C(=O)NO)NCC2=CC=CC=C2 |
| IUPAC Name | 3-(benzylamino)-N-hydroxy-4-methylbenzamide |
| InChIKey | PZBARTUEWCQNSN-UHFFFAOYSA-N |
| INCHI | 1S/C15H16N2O2/c1-11-7-8-13(15(18)17-19)9-14(11)16-10-12-5-3-2-4-6-12/h2-9,16,19H,10H2,1H3,(H,17,18) |
| Isomères SMILES | CC1=C(C=C(C=C1)C(=O)NO)NCC2=CC=CC=C2 |
| PubChem CID | 134159676 |
| Poids moléculaire | 256.3 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Benzenoids |
| Classe | Benzene and substituted derivatives |
| Subclass | Phenylmethylamines |
| Intermediate Tree Nodes | Not available |
| Direct Parent | Phenylbenzamines |
| Alternative Parents | Aminobenzoic acids and derivatives p-Toluamides Phenylalkylamines Benzylamines Benzoyl derivatives Aniline and substituted anilines Aminotoluenes Secondary alkylarylamines Hydroxamic acids Amino acids and derivatives Organopnictogen compounds Organooxygen compounds Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Phenylbenzamine - Aminobenzoic acid or derivatives - P-toluamide - Toluamide - Benzoic acid or derivatives - Aminotoluene - Phenylalkylamine - Aniline or substituted anilines - Benzylamine - Benzoyl - Aralkylamine - Toluene - Secondary aliphatic/aromatic amine - Hydroxamic acid - Amino acid or derivatives - Secondary amine - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Amine - Aromatic homomonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as phenylbenzamines. These are aromatic compounds consisting of a benzyl group that is N-linked to a benzamine. |
| External Descriptors | Not available |
| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Activity Type | Relation | Activity value | Units | Action Type | Journal | PubMed Id | doi | Assay Aladdin ID |
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| Sensibilité | light sensitive |
|---|---|
| DMSO (mg/mL) Solubilité maximale | 51 |
| DMSO (mM) Solubilité maximale | 198.985563792431 |
| Eau (mg/mL) Solubilité maximale | ＜1 |
| Poids moléculaire | 256.300 g/mol |
| XLogP3 | 2.600 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 4 |
| Exact Mass | 256.121 Da |
| Monoisotopic Mass | 256.121 Da |
| Topological Polar Surface Area | 61.400 Ų |
| Heavy Atom Count | 19 |
| Formal Charge | 0 |
| Complexity | 290.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
