Thioacetamide(TAA) - ACS, ≥99% , CAS No.62-55-5
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SKU
T118452
Thioacetamide is a thiocarbonyl compound. It undergoes deuterium exchange reaction with D2O to afford N-dideuterated thioacetamide. Infrared spectral investigations of thioacetamide and its deuterated derivative (N-dideuterated thioacetamide) have been reported.
Usually used as Hepatotoxin and carcinogen,and also used as an additive in enantioselective reduction of β-keto esters with immobilized baker′s yeast.
Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model.
Plus d’information
| CAS | 62-55-5 |
|---|---|
| Synonymes | CH3CSNH2 | F0001-1649 | EC 200-541-4 | Ethanimidothioic acid | Tox21_301295 | Acetothioamide | EN300-19496 | Thioacetamide, Vetec(TM) reagent grade, 98% | Z104474020 | USAF EK-1719 | Acetamide, thio- (VAN) | D70870 | THIOACETAMIDE [HSDB] | C2H5NS | CHEBI: |
| Spécifications et pureté | ACS, ≥99% |
| Conditions de stockage de stockage | Room temperature |
| Expédié en | Normal |
| Product Description | Thioacetamide is a thiocarbonyl compound. It undergoes deuterium exchange reaction with D2O to afford N-dideuterated thioacetamide. Infrared spectral investigations of thioacetamide and its deuterated derivative (N-dideuterated thioacetamide) have been reported.
Thioacetamide (TAA) is an indirect hepatotoxin and causes parenchymal cell necrosis. Thioacetamide requires metabolic activation by microsomal CYP2E1 to thioacetamide-S-oxide initially and then to thioacetamide-S-dioxide, which is a highly reactive metabolite, and its reactive metabolites covalently bind to proteins and lipids thereby causing oxidative stress and centrilobular necrosis. Thioacetamide can induce chronic liver fibrosis, encephalopathy and other events model.
|
| Pubchem Sid | 504760838 |
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504760838 |
| Solubilité | Soluble in ethanol, benzene and petroleum ether. Slightly soluble in water and ether. |
| Sensibilité | Moisture sensitive. |
| Numéro Mdl | MFCD00008070 |
| Numéro CE | 200-541-4 |
| PubChem CID | 2723949 |
| Formule moléculaire | C2H5NS |
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