Tinidazole - Moligand™, 10mM in DMSO , DNA inhibitor, CAS No.19387-91-8, DNA inhibitor

CAS: 19387-91-8 Cat. No.: T407955 Formule: C₈H₁₃N₃O₄S Poids moléculaire: 247.27 Numéro CE: 243-014-4 PubChem CID: 5479

QUALITÉ & PURETÉ Moligand™, 10mM in DMSO

Synonyms

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

Information

Tinidazole Tinidazole (CP12574) is an anti-parasitic drug.
In vitro

Tinidazole kills the metronidazole-susceptible isolates at a low MLC but is effective against only 4 of the 12 metronidazole-resistant isolates. Tinidazole exhibits activity against pathogenic protozoa (eg, Tricbomonas vaginalis, Entamoeba bistolytica, Giardia duodenalis), a wide range of clinically significant anaerobic bacteria (eg, Bacteroides fragilis, Clostridium difficile), and the microaerophilic bacterium Helicobacter pylori. Tinidazole is reduced to cytotoxic intermediates that covalently bind to DNA, causing irreversible damage in susceptible protozoal and bacterial cells. Tinidazole inhibits against 104 T. vaginalis isolates with mean MLC of 1014.9 μM. Tinidazole slightly affects trophozoite morphology, adherence and viability against Giardia duodenalis. Tinidazole is against 40 Clostridium difficile, 10 Prevotella bivia and 11 Bacteroides fragilis clinical isolates, the geometric mean MICs of tinidazole and metronidazole are, respectively: C. difficile, 0.31 μg/mL and 0.28 μg/mL; P. bivia, 2.33 μg/mL and 1.52 μg/mL; B. fragilis, 0.5 μg/mL and 0.71 μg/mL.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Spécifications

Synonymes

CP12574 | 1H-Imidazole, 1-[2-(ethylsulfonyl)ethyl]-2-methyl-5-nitro-

Spécifications et pureté

Moligand™, 10mM in DMSO

Mécanismes biochimiques et physiologiques

Tinidazole (CP12574) is an anti-parasitic drug.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Mécanisme d'action

DNA inhibitor

Noms et identifiants

Isomères SMILES

CCS(=O)(=O)CCN1C(=NC=C1[N+](=O)[O-])C

RTECS

NI6255000

PubChem CID

5479

Poids moléculaire

247.27

Reaxy-Rn

618182

Propriétés chimiques et physiques

• Solubilité: Solubility (25°C) In vitro DMSO: 100 mg/mL (162.21 mM); Water: Insoluble; Ethanol: Insoluble
• Point de fusion (°C): 129 °C