TMX-201 - ≥98% , CAS No.1149339-78-5

CAS: 1149339-78-5 Cat. No.: T649137 Formule: C₅₇H₉₃N₆O₁₂P Poids moléculaire: 1085.36

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Vue d’ensemble

TMX-201 is a TLR7 ligand-phospholipid conjugate. TMX-201 shows potent immune stimulatory activity. TMX-201 can be used for breast cancer and melanoma research

In Vitro

TMX-201 is more potent cytokine inducer than Imiquimod in both mouse and human mononuclear cells. TMX-201 shows less off-target binding compared to Imiquimod. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

The maximum tolerated dose of TMX-201 by i.v. administration is 75 mg/kg . TMX-201 (4mg/kg, IP) suppresses the growth of established subcutaneous B16 melanoma by 46%, without discernible adverse effects . TMX-201 (IP or intra-tumor administration), in combination with anti-CTLA4 antibody, significantly suppressed lung metastasis formation in the 4T1 breast cancer model . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:TLR7

Specifications

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

TMX-201 is a TLR7 ligand-phospholipid conjugate. TMX-201 shows potent immune stimulatory activity. TMX-201 can be used for breast cancer and melanoma research.

Conditions de stockage de stockage

Store at 2-8°C,Protected from light,Desiccated

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥98%

Noms et identifiants

• Sourires canoniques: O=C(N(C1=NC(OCCOC)=N2)CC3=CC=C(C=C3)C(NCCOP(OC[C@@H](COC(CCCCCCC/C=C\\CCCCCCCC)=O)OC(CCCCCCC/C=C\\CCCCCCCC)=O)(O)=O)=O)NC1=C2N
• Poids moléculaire: 1085.36

Propriétés chimiques et physiques

• Solubilité: DMSO : 50 mg/mL (46.07 mM; ultrasonic and warming and heat to 60°C)