TyK2-IN-2 - 10mM in DMSO , CAS No.2098466-94-3

CAS: 2098466-94-3 Cat. No.: T654529 Formule: C₁₆H₁₈N₆O Poids moléculaire: 310.35 PubChem CID: 129626433

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC 50 s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2 , IL-23 and IFNα , respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC 50 of 62 nM. TyK2-IN-2 can be used for the research of inflammatory and autoimmune diseases

In Vitro

A co-crystal structure of TyK2-IN-2 (Compoud 18) bound to the TYK2 JH2 is solved. First, limited room between C8 and the hinge is seen, consistent with the loss in affinity seen with groups larger than methylamino at this position. There are also hydrogen bonds revealed between the NH of the C8 methylamine and from N1 of the IZP core to the ‘hinge’ (Val690). Additional hydrogen bonds are observed from the oxygen of the C3 amide to Lys642 and to the hinge carbonyl of Glu688 through a bridging water molecule. The pocket proximal to the C3 amide of the TYK2 JH2 domain contains a combination of residues which are largely unique relative to the kinome such as a small residue (Ala671) under the “gatekeeper” (Thr687) and the replacement of the highly kinase-conserved DFG motif by DPG which alters the positioning of the conserved catalytic Lys642 and Asp759. The ability of the C3 amide to fit and bind to this pocket is believed to be a key source of kinome selectivity for TyK2-IN-2 (Compoud 18). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:Tyk2 JH2 7 nM (IC 50 ) PDE4 62 nM (IC 50 )

Specifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

TyK2-IN-2 (Compoud 18) is a potent and selective TYK2 inhibitor with IC 50 s of 7 nM, 0.1 μM and 0.05 μM for TYK2 JH2 , IL-23 and IFNα , respectively. TyK2-IN-2 also inhibits phosphodiesterase 4 (PDE4) with an IC 50 of 62 nM. TyK2-IN-2 can be used for the

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

• Isomères SMILES: CC1=CC(=CC(=C1)NC2=NN3C(=CN=C3C(=C2)NC)C(=O)N)C
• PubChem CID: 129626433
• Poids moléculaire: 310.35

Cibles associées (humaines)

TYK2 Tclin Non-receptor tyrosine-protein kinase TYK2 (1 Activities)

Discover Target: TYK2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDE4D Tclin cAMP-specific 3',5'-cyclic phosphodiesterase 4D (1 Activities)

Discover Target: PDE4D

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Foire aux questions

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 2098466-94-3, the molecular formula is C16H18N6O, and the molecular weight is 310.35 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.