Valiltramiprosate - 10mM in Water , Beta amyloid A4 protein stabiliser, CAS No.1034190-08-3, Beta amyloid A4 protein stabiliser

CAS: 1034190-08-3 Cat. No.: V655398 Formule: C₈H₁₈N₂O₄S Poids moléculaire: 238.30 PubChem CID: 25008296

GRADE & PURITY 10mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent compound ALZ-801 is an advanced and markedly improved candidate for the treatment of alzheimer’s disease .

In Vivo

ALZ-801 (oral administration; 172?mg/kg; single dose) exhibits mean AUCt values of 58,758 and? 5841 ng/ml.h in plasma and brain, respectively. The ALZ-801: Tramiprosate ratio in plasma and brain is 1.8 and 3.1, respectively in male CD-1 mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:β-amyloid

Specifications

Spécifications et pureté

10mM in Water

Mécanismes biochimiques et physiologiques

ALZ-801 is a potent and orally available small-molecule β-amyloid (Aβ) anti-oligomer and aggregation inhibitor, valine-conjugated proagent of Tramiprosate with substantially improved PK properties and gastrointestinal tolerability compared with the parent

Conditions de stockage de stockage

Desiccated,Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Type d'action

STABILISER

Mécanisme d'action

Beta amyloid A4 protein stabiliser

Propriétés du produit

• ALogP: -3

Noms et identifiants

• Isomères SMILES: CC(C)[C@@H](C(=O)NCCCS(=O)(=O)O)N
• PubChem CID: 25008296
• Poids moléculaire: 238.30