JAK3 kinase inhibitor. Also inhibits EGFR
WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.
A JAK3 inhibitor which inhibits other common kinases.
| CAS | 211555-04-3 |
|---|---|
| Synonymes | HB1431 | BCP09619 | SR-02000000171 | 4-(3'-bromo-4'-hydroxyphenyl)amino-6,7-dimethoxyquinazoline | GTPL5993 | 2-Bromo-4-[(6,7-dimethoxy-4-quinazo linyl)amino]phenol | WHI-P 154 | NCGC00351598-08 | WHI P154 | AS-55999 | AKOS024457435 | HMS3651J21 | AC-3205 |
| Spécifications et pureté | Moligand™, ≥98% |
| Conditions de stockage de stockage | Store at -20°C |
| Expédié en | Ice chest + Ice pads |
| Product Description | WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation. |
| Pubchem Sid | 528768441 |
| Solubilité | Solvent:DMSO, Max Conc. mg/mL: 37.62, Max Conc. mM: 100 |
| Sensibilité | Heat Sensitive |
| Numéro Mdl | MFCD02179366 |
| Numéro CE | 809-014-9 |
| PubChem CID | 3795 |
