WRG-28 - Moligand™, ≥96% , CAS No.1913291-02-7

CAS: 1913291-02-7 Cat. No.: W647303 Formule: C₂₁H₁₈N₂O₅S Poids moléculaire: 410.44 PubChem CID: 139035038

GRADE & PURITY Moligand™, ≥96%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

WRG-28 is a selective, extracellularly acting DDR2 allosteric inhibitor, with an IC50 of 230 nM. WRG-28 inhibits tumor invasion, migration and tumor-supporting effects of cancer-associated fibroblasts (CAFs). WRG-28 inhibits metastatic breast tumor cell colonization in the lungs. WRG-28 also shows good activity of relieving rheumatoid arthritis in CAIA model of mice.

Specifications

Spécifications et pureté

Moligand™, ≥96%

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Grade

Moligand™

Type d'action

INHIBITOR

Pureté

≥96%

Noms et identifiants

• Sourires canoniques: CCNS(=O)(=O)C1=CC=C(C=C1)COC2=CC3=C(C=C2)N=C4C=CC(=O)C=C4O3
• IUPAC Name: N-ethyl-4-[(7-oxophenoxazin-3-yl)oxymethyl]benzenesulfonamide
• InChIKey: AARVTLIQNGAELZ-UHFFFAOYSA-N
• INCHI: 1S/C21H18N2O5S/c1-2-22-29(25,26)17-7-3-14(4-8-17)13-27-16-6-10-19-21(12-16)28-20-11-15(24)5-9-18(20)23-19/h3-12,22H,2,13H2,1H3
• PubChem CID: 139035038
• Poids moléculaire: 410.44

Propriétés chimiques et physiques

• Solubilité: DMSO : 15.62 mg/mL (38.06 mM; Need ultrasonic)
• Poids moléculaire: 410.400 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 6
• Exact Mass: 410.094 Da
• Monoisotopic Mass: 410.094 Da
• Topological Polar Surface Area: 102.000 Ų
• Heavy Atom Count: 29
• Formal Charge: 0
• Complexity: 818.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1