X5050 - ≥98% , CAS No.2404756-81-4

CAS: 2404756-81-4 Cat. No.: X651956 Formule: C₁₇H₁₅N₃O₃ Poids moléculaire: 309.32 PubChem CID: 146301742

GRADE & PURITY ≥98%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Vue d’ensemble

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

In Vitro

X5050 (100 µM, 1 day) induces a dosedependent decrease in the REST isoform in protein level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: NSCs. Concentration: 100 µM. Incubation Time: One day. Result: Induced a dosedependent decrease in the 122 kDa longer REST isoform.

In Vivo

X5050 (2 x 2µl of 20 mM) is active in HD pathological context . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 12-week-old male C57Bl6 mice .2 Dosage: 2 x 2µl of 20 mM in 10% DMSO in water. Administration: Intraventricular injection. Result: Increased BDNF expression. A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum. Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed.

Form:Solid

Specifications

Spécifications et pureté

≥98%

Mécanismes biochimiques et physiologiques

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥98%

Noms et identifiants

• Sourires canoniques: C=CCONC(=O)C1=CC2=C(C=C1)N=C(N2)C3=CC=CC=C3O
• IUPAC Name: 2-(2-hydroxyphenyl)-N-prop-2-enoxy-3H-benzimidazole-5-carboxamide
• InChIKey: RGROIKJLROTDCR-UHFFFAOYSA-N
• INCHI: 1S/C17H15N3O3/c1-2-9-23-20-17(22)11-7-8-13-14(10-11)19-16(18-13)12-5-3-4-6-15(12)21/h2-8,10,21H,1,9H2,(H,18,19)(H,20,22)
• PubChem CID: 146301742
• Poids moléculaire: 309.32

Propriétés chimiques et physiques

• Solubilité: DMSO : 100 mg/mL (323.29 mM; Need ultrasonic)