X5050 - 10mM in DMSO , CAS No.2404756-81-4

CAS: 2404756-81-4 Cat. No.: X656895 Formule: C₁₇H₁₅N₃O₃ Poids moléculaire: 309.32 PubChem CID: 146301742

QUALITÉ & PURETÉ 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Vue d’ensemble

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

In Vitro

X5050 (100 µM, 1 day) induces a dosedependent decrease in the REST isoform in protein level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot AnalysisCell Line: NSCs. Concentration: 100 µM. Incubation Time: One day. Result: Induced a dosedependent decrease in the 122 kDa longer REST isoform.

In Vivo

X5050 (2 x 2µl of 20 mM) is active in HD pathological context . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: 12-week-old male C57Bl6 mice .2 Dosage: 2 x 2µl of 20 mM in 10% DMSO in water. Administration: Intraventricular injection. Result: Increased BDNF expression. A decrease in Darpp32 and Snap25 expression was found by QRT-PCR in the lesioned striatum as compared with the contralateral striatum. Significantly increased the levels of Bdnf II splice variant (exon II containing variant) while Bdnf IV levels were not significantly changed.

Spécifications

Spécifications et pureté

10mM in DMSO

Mécanismes biochimiques et physiologiques

X5050 is a REST inhibitor, with an EC 50 of 2.1 μM.

Conditions de stockage de stockage

Store at -80°C

Expédié en

Dry ice packs + Cold packs

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Noms et identifiants

PubChem CID

146301742

Poids moléculaire

309.32