XL01126 - ≥99% , CAS No.X658669

CAS: X658669 Cat. No.: X658669 Formule: C₅₀H₆₄ClFN₁₀O₆S₂ Poids moléculaire: 1019.69

QUALITÉ & PURETÉ ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Application

PROTAC

Vue d’ensemble

XL01126 is a potent degrader of LRRK2 with DC 50 s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research. XL01126 exerts function of study of non-c

Appearance:Solid

IC50& Target:DC50: 15-72 nM (LRRK2)

In Vitro:XL01126 (300 nM; 4 h) exhibits strong degradation performance by forming a positively cooperative ternary complex with E3 ubiquitin ligase ligand VHL and target protein LRRK2. XL01126 (10, 30, 100 nM; 24 h) increases mitophagy in immortalized mouse e

In Vivo:XL01126 (30mg/kg; p.o.; single dose) shows oral activity with bioavailable value (F) of 15% and can penetrate the blood brain barrier after either oral or parenteral dosing in mice. Pharmacokinetic property of XL01126 in miceRoute Dose mg/kg)

Biological Activity:XL01126 is a potent degrader of LRRK2 with DC 50 s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research . XL01126 exerts function of study of non-

Spécifications

Spécifications et pureté

≥99%

Conditions de stockage de stockage

Store at -20°C

Expédié en

Ice chest + Ice pads

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥99%

Noms et identifiants

Poids moléculaire

1019.69

Propriétés chimiques et physiques

• Solubilité: DMSO : ≥ 100 mg/mL (98.07 mM)