YB-0158 - ≥99% , CAS No.1144043-83-3

CAS: 1144043-83-3 Cat. No.: Y647886 Formule: C₃₂H₃₂N₇Na₂O₇P Poids moléculaire: 703.59

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Vue d’ensemble

YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities

In Vitro

YB-0158 (0.2 μM and 0.5 μM; 48 hours) significantly increases apoptosis in CRC cells as represented by activated Caspase-3/7 detection assays. YB-0158 (0.3 μM) similarly decreases CBP recruitment at the promoter of Wnt/beta-Catenin target genes LGR5 and MYC in HT29 cells, compared with DMSO control. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

YB-0158 displays an EC 50 (1.64 μM) in cultured MC38 cells. YB-0158 (100 mg/kg; IP; C57BL/6 mice bearing MC38 cells) shows no significant differences in primary tumor size in vivo treatments versus saline controls. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Wnt signaling

Specifications

Spécifications et pureté

≥99%

Mécanismes biochimiques et physiologiques

YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activities.

Conditions de stockage de stockage

Store at 2-8°C,Desiccated

Expédié en

Wet ice

Ce produit nécessite l'expédition en chaîne froide. Les services terrestres et autres services économiques ne sont pas disponibles.

Pureté

≥99%

Noms et identifiants

Sourires canoniques

O=P(O[Na])(O[Na])OC1=CC=C(C[C@H]2C(N(CC3=CC=CC4=C3NN=C4)C[C@H](N(C(NCC5=CC=CC=C5)=O)N(CC=C)C6)N2C6=O)=O)C=C1

Poids moléculaire

703.59

Propriétés chimiques et physiques

• Solubilité: DMSO : 100 mg/mL (142.13 mM; Need ultrasonic) H2O : <0.1 mg/mL (ultrasonic;adjust pH to 1 with 1M HCl) (insoluble)