Zoledronic Acid - Moligand™, ≥99% , Farnesyl diphosphate synthase inhibitor, CAS No.118072-93-8, Farnesyl diphosphate synthase inhibitor

CAS: 118072-93-8 Cat. No.: Z129382 Molecular Weight: 272.09 EC Number: 871-741-2 PubChem CID: 68740
AVAILABLE TO ORDER
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
Synonyms
70HZ18PH24 | CAS-118072-93-8 | SR-05000001436 | (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid | D08689 | FT-0601384 | GTPL3177 | NCGC00159521-02 | s1314 | AB01273947-03 | 1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid | AB01
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
25mg
Z129382-25mg
4

$9.90

$14.90
Save $5.00 (33.56%)
100mg
Z129382-100mg
4

$15.90

$23.90
Save $8.00 (33.47%)
1g
Z129382-1g
5

$79.90

$119.90
Save $40.00 (33.36%)
5g
Z129382-5g
3

$298.90

$448.90
Save $150.00 (33.42%)
25g
Z129382-25g
1

$1,118.90

$1,678.90
Save $560.00 (33.36%)
Enter a quantity for the sizes you want to add.
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Why this grade

Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 11 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms
70HZ18PH24 | CAS-118072-93-8 | SR-05000001436 | (1-hydroxy-2-(1H-imidazol-1-yl)ethylidene)bisphosphonic acid | D08689 | FT-0601384 | GTPL3177 | NCGC00159521-02 | s1314 | AB01273947-03 | 1-hydroxy-2-(1H-imidazol-1-yl)ethane-1, 1-diyldiphosphonic acid | AB01
Specifications & Purity
Moligand™, ≥99%
Biochemical and Physiological Mechanisms
Highly potent bisphosphonate. FPP synthase inhibitor. Inhibits osteoclastogenesis (IC 50 = 15 nM). Inhibits ASM and FDPS. Activates PKC. Inhibits osteoclastic bone resorption, shows antihypocalcemic and antiangiogenic effects in vivo.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
INHIBITOR
Mechanism of action
Farnesyl diphosphate synthase inhibitor
Note
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
Purity
≥99%
Product Properties
ALogP-4.3
Names and Identifiers
Pubchem Sid488184180
Pubchem Sid Urlhttps://pubchem.ncbi.nlm.nih.gov/substance/488184180
Canonical SmilesC1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
IUPAC Name(1-hydroxy-2-imidazol-1-yl-1-phosphonoethyl)phosphonic acid
InChIKeyXRASPMIURGNCCH-UHFFFAOYSA-N
INCHI1S/C5H10N2O7P2/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14)
Isomeric SMILES C1=CN(C=N1)CC(O)(P(=O)(O)O)P(=O)(O)O
PubChem CID 68740
Molecular Weight 272.09

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic acids and derivatives
ClassOrganic phosphonic acids and derivatives
SubclassBisphosphonates
Intermediate Tree Nodes Not available
Direct ParentBisphosphonates
Alternative Parents N-substituted imidazoles  Organic phosphonic acids  Heteroaromatic compounds  Azacyclic compounds  Organopnictogen compounds  Organophosphorus compounds  Organooxygen compounds  Organonitrogen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAromatic heteromonocyclic compounds
Substituents Bisphosphonate - N-substituted imidazole - Heteroaromatic compound - Organophosphonic acid - Imidazole - Azole - Azacycle - Organoheterocyclic compound - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organophosphorus compound - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as bisphosphonates. These are organic compounds containing two phosphonate groups linked together through a carbon atoms.
External Descriptors imidazoles - 1,1-bis(phosphonic acid)
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
FDPS Tclin Farnesyl pyrophosphate synthase (29 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA2 Tclin Carbonic anhydrase 2 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA12 Tclin Carbonic anhydrase 12 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
CA14 Tclin Carbonic anhydrase 14 (2 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
BTN3A1 Tchem Butyrophilin subfamily 3 member A1 (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

33 results found

Lot NumberCertificate TypeDateItem
A2609488Certificate of AnalysisJan 04, 2026 Z129382
A2609494Certificate of AnalysisJan 04, 2026 Z129382
A2609495Certificate of AnalysisJan 04, 2026 Z129382
A2609497Certificate of AnalysisJan 04, 2026 Z129382
A2609344Certificate of AnalysisJan 04, 2026 Z129382
G23221033Certificate of AnalysisMay 07, 2025 Z129382
G23221042Certificate of AnalysisMay 07, 2025 Z129382
G23221038Certificate of AnalysisMay 07, 2025 Z129382
G23221037Certificate of AnalysisMay 07, 2025 Z129382
G23221034Certificate of AnalysisMay 07, 2025 Z129382
G23221017Certificate of AnalysisMay 07, 2025 Z129382
J2414675Certificate of AnalysisOct 08, 2024 Z129382
J2414668Certificate of AnalysisOct 08, 2024 Z129382
J2414667Certificate of AnalysisOct 08, 2024 Z129382
J2414643Certificate of AnalysisOct 08, 2024 Z129382
I2522068Certificate of AnalysisOct 08, 2024 Z129382
G2531049Certificate of AnalysisOct 08, 2024 Z129382
G2511090Certificate of AnalysisOct 08, 2024 Z129382
J2414669Certificate of AnalysisOct 08, 2024 Z129382
H2406230Certificate of AnalysisMar 02, 2024 Z129382
G23221040Certificate of AnalysisJul 07, 2023 Z129382
G23221041Certificate of AnalysisJul 07, 2023 Z129382
C2415131Certificate of AnalysisJul 07, 2023 Z129382
H2429022Certificate of AnalysisJul 07, 2023 Z129382
G23221028Certificate of AnalysisJul 07, 2023 Z129382
C2130027Certificate of AnalysisJan 12, 2023 Z129382
C2130024Certificate of AnalysisJan 12, 2023 Z129382
C2130026Certificate of AnalysisJan 12, 2023 Z129382
D1912082Certificate of AnalysisDec 06, 2022 Z129382
F2230307Certificate of AnalysisJul 04, 2022 Z129382
F2215113Certificate of AnalysisJun 23, 2022 Z129382
E2312259Certificate of AnalysisJun 23, 2022 Z129382
C2011020Certificate of AnalysisJan 27, 2022 Z129382

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Chemical and Physical Properties
SolubilityDMSO 0.004 mg/mL Water <1 mg/mL Ethanol <1 mg/mL
Molecular Weight272.090 g/mol
XLogP3-4.300
Hydrogen Bond Donor Count5
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass271.996 Da
Monoisotopic Mass271.996 Da
Topological Polar Surface Area153.000 Ų
Heavy Atom Count16
Formal Charge0
Complexity327.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Citations of This Product
References
1. Wanzhen Li, Yongqi Yang, Jun Wang, Ting Ge, Shuixia Wan, Lin Gui, Yugui Tao, Ping Song, Liangjun Yang, Fei Ge, Weiwei Zhang.  (2023)  Establishment of bone-targeted nano-platform and the study of its combination with 2-deoxy-d-glucose enhanced photodynamic therapy to inhibit bone metastasis.  Journal of the Mechanical Behavior of Biomedical Materials,      [PMID:38091923] [10.1016/j.jmbbm.2023.106306]
2. Yao Duan, Chanyuan Jin, Yuwei Wu, Yan Chen, Minjuan Zhang, Jun Qian, Ting Shuai, Jian Li, Huimin Chen, Dan Li.  (2023)  CREB1 alleviates the apoptosis and potentiates the osteogenic differentiation of zoledronic acid-treated human periodontal ligament stem cells via up-regulating VEGF.  TISSUE & CELL,      [PMID:37776785] [10.1016/j.tice.2023.102223]
3. Ting Ge, Zhang Weiwei, Fei Ge, Longbao Zhu, Ping Song, Wanzheng Li, Lin Gui, Wan Dong, Yugui Tao, Kai Yang.  (2022)  A bone-targeting drug delivery vehicle of a metal–organic framework conjugate with zoledronate combined with photothermal therapy for tumor inhibition in cancer bone metastasis.  Biomaterials Science,  10  (7): (1831-1843).  [PMID:35253030] [10.1039/D1BM01717A]
4. Xi Cui, Yizhu Shan, Jiaxuan Li, Meng Xiao, Yuan Xi, Jianying Ji, Engui Wang, Baokun Zhang, Lingling Xu, Mingzhu Zhang, Zhou Li, Yingzi Zhang.  (2024)  Bifunctional Piezo-Enhanced PLLA/ZA Coating Prevents Aseptic Loosening of Bone Implants.  ADVANCED FUNCTIONAL MATERIALS,      [PMID:] [10.1002/adfm.202403759]
5. Wei Wang, Xing Zhang, Lichen Zhang, Ziang Li, Lingjun Wang, Xinzhao Jiang, Jie Wu, Liang Zhou, Qiangqiang Guo, Yiyang Huang, Wenbo Wang, Kun Xi, Gert Storm, Yong Gu, Liang Chen.  (2025)  An Immunomodulating Regenerating Hydrogel That Rescues the Oxidative Microenvironment and Reverses Cell Senescence for Osteoporotic Bone Defects.  ACS Nano,      [PMID:40754989] [10.1021/acsnano.5c06549]
6. Li Luyao, Wang Cheng, Chu Weicun, Park Jaewang, Dai Yiming, Ba Qiankai, Wang Kaifeng, Gao Jiaxing, Wei Zeliang, Zhao Xiaoming, Nie Xuchen, Yin Lixiong, Seok Sang Il, Nie Riming, Guo Wanlin.  (2025)  Fully chemical interface engineering for statically and dynamically stable perovskite solar cells.  Nature Communications,  16  (1): (1-11).  [PMID:41022772] [10.1038/s41467-025-63588-8]
7. Min Zhang, Dehui Fan, Wenchang Wu, Lixin Feng, Tong Sun, Hua Yang, Guoqiang Zhou, Jinchao Zhang, Yu Han, Kun Ge.  (2025)  Bone-targeting single-atom nanozymes for treating breast cancer bone metastasis via the synergistic effect of mild photothermal and chemodynamic therapy.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:40946508] [10.1016/j.jcis.2025.139000]
8. Dehui Fan, Jing Li, Luwei Li, Ming An, Hua Yang, Guoqiang Zhou, Shutao Gao, Massimo Bottini, Jinchao Zhang, Kun Ge.  (2024)  Phosphate Ion-Responsive and Calcium Peroxide-Based Nanomedicine for Bone-Targeted Treatment of Breast Cancer Bone Metastasis.  Advanced Healthcare Materials,      [PMID:39109966] [10.1002/adhm.202402216]
9. Fuchao Chu, Zhenxin Wang, Dazhen Zhang, Wenkang Xu, Boyan Huang, Chen Long, Shuo Yang, Xinzhe Qu, Cunjiu Gao, Feng Yuan.  (2024)  Research on the osteogenic properties of 3D-printed porous titanium alloy scaffolds loaded with Gelma/PAAM-ZOL composite hydrogels.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:39038567] [10.1016/j.ijbiomac.2024.134050]
10. Enyang Yao, Yang Li, Kai Deng, Wei He, Milad Ashrafizadeh, João Conde, Liyu Yang.  (2025)  Folic acid-targeted macrophage membrane-coated carbon quantum dot nanoplatform for dual drug and gene delivery in metastatic osteosarcoma therapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.163227]
11. Fu Xiaoxue, Luo Zhenyu, Guo Yuqi, Meng Weikun, Jin Shue, Chen Junyu, Cai Yongrui, Luo Zeyu, Huang Chao, Chen Anjing, Guo Siqin, Chen Maojia, Zhou Zongke, Zeng Weinan.  (2025)  Microenvironment-responsive multifunctional enzyme-linked hydrogel for diabetic bone defect regeneration.  Nature Communications,  16  (1): (10275).  [PMID:41271711] [10.1038/s41467-025-65165-5]
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