Via MAPK/ERK - proteina chinasi 3 attivata dal mitogeno Supplier | High Purity

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Selonsertib (GS-4997), Mitogen-activated protein kinase kinase kinase 5 inhibitor
CAS: 1448428-04-3 Numero EC: 822-332-2 PubChem CID: 71245288 Formula: C₂₄H₂₄FN₇O Peso molecolare: 445.49

Moligand™ ? ≥99%

● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: S413964
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5-(4-cyclopropylimidazol-1-yl)-2-fluoro-4-methyl-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]benzamide

SMILES

CC1=CC(=C(C=C1N2C=C(N=C2)C3CC3)C(=O)NC4=CC=CC(=N4)C5=NN=CN5C(C)C)F

InChIKey
YIDDLAAKOYYGJG-UHFFFAOYSA-N

InChI

1S/C24H24FN7O/c1-14(2)32-13-27-30-23(32)19-5-4-6-22(28-19)29-24(33)17-10-21(15(3)9-18(17)25)31-11-20(26-12-31)16-7-8-16/h4-6,9-14,16H,7-8H2,1-3H3,(H,2show more

Sinonimi
AMY27913 | HY-18938 | 1448428-04-3 | (2S,SR)-METHIONINE SULFOXIMINE | EX-A1618 | GS 4997 | Selonsertib (GS-4997) | UN...
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Takinib, Inhibitor of CDC like kinase 2;Inhibitor of interleukin 1 receptor associated kinase 1;Inhibitor of interleukin 1 receptor associated kinase 4;Inhibitor of mitogen-activated protein kinase kinase kinase 7
CAS: 1111556-37-6 Numero EC: 841-675-9 PubChem CID: 37750349 Formula: C₁₈H₁₈N₄O₂ Peso molecolare: 322.37

Moligand™ ? 10mM in DMSO

● In magazzino — Magazzino negli USA, spedizione nell'EU* Oggetto #: T420617
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3-N-(1-propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide

SMILES

CCCN1C2=CC=CC=C2N=C1NC(=O)C3=CC=CC(=C3)C(=O)N

InChIKey
UOZVVPXKJGOFIG-UHFFFAOYSA-N

InChI

1S/C18H18N4O2/c1-2-10-22-15-9-4-3-8-14(15)20-18(22)21-17(24)13-7-5-6-12(11-13)16(19)23/h3-9,11H,2,10H2,1H3,(H2,19,23)(H,20,21,24)

Sinonimi
N17080 | SCHEMBL20063046 | F0918-1884 | A928060 | Tox21_300612 | Diethyl phthalate, 99% | NSC789624 | NSC-789624 | UN...
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pelubiprofen
CAS: 69956-77-0 PubChem CID: 5282203

Moligand™ ?

◐ .Su ordinazione · 8–12 settimane Oggetto #: P612684
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2-[4-[(E)-(2-oxocyclohexylidene)methyl]phenyl]propanoic acid

SMILES

CC(C1=CC=C(C=C1)C=C2CCCCC2=O)C(=O)O

InChIKey
AUZUGWXLBGZUPP-GXDHUFHOSA-N

InChI

1S/C16H18O3/c1-11(16(18)19)13-8-6-12(7-9-13)10-14-4-2-3-5-15(14)17/h6-11H,2-5H2,1H3,(H,18,19)/b14-10+

Sinonimi
(+-)-p-(((E)-2-Oxocyclohexylidene)methyl)hydratropic acid | CAS-69956-77-0 | DB12150 | Q27251763 | Benzeneacetic acid...
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Cot inhibitor-1
CAS: 915365-57-0 PubChem CID: 11584834 Formula: C₂₇H₂₇Cl₂FN₈ Peso molecolare: 553.46

≥98%

◐ .Su ordinazione · 8–12 settimane Oggetto #: C646885
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PF-05381941
CAS: 1474022-02-0 Formula: C₂₇H₂₆N₆O₂ Peso molecolare: 466.53

≥99%

◐ .Su ordinazione · 8–12 settimane Oggetto #: P647400
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TAK1/MAP4K2 inhibitor 1
CAS: 1315330-11-0 PubChem CID: 71254032 Formula: C₂₉H₃₁F₃N₆O₂ Peso molecolare: 552.59

≥98%

◐ .Su ordinazione · 8–12 settimane Oggetto #: T648184
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N-[4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-4-methyl-3-[(6-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy]benzamide

SMILES

CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)C3=CC(=C(C=C3)C)OC4=NC=NC5=C4C=C(N5)C)C(F)(F)F

InChIKey
RWNAOXLCVXJMGM-UHFFFAOYSA-N

InChI

1S/C29H31F3N6O2/c1-4-37-9-11-38(12-10-37)16-21-7-8-22(15-24(21)29(30,31)32)36-27(39)20-6-5-18(2)25(14-20)40-28-23-13-19(3)35-26(23)33-17-34-28/h5-8,13show more

Sinonimi
AKOS016012030 | n-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-4-methyl-3-((6-methyl-7h-pyrrolo[2,3-...
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DLK-IN-1
CAS: 1620574-24-4 PubChem CID: 90292823 Formula: C₂₀H₂₄F₃N₅O₂ Peso molecolare: 423.43

Solido ≥98%

◐ .Su ordinazione · 8–12 settimane Oggetto #: D650308
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5-[5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]-1-propan-2-ylpyrazol-3-yl]-3-(trifluoromethoxy)pyridin-2-amine

SMILES

CC(C)N1C(=CC(=N1)C2=CC(=C(N=C2)N)OC(F)(F)F)C3C4C3CN(C4)C5COC5

InChIKey
UHEFRVBGJORHNV-UUVAVEHKSA-N

InChI

1S/C20H24F3N5O2/c1-10(2)28-16(18-13-6-27(7-14(13)18)12-8-29-9-12)4-15(26-28)11-3-17(19(24)25-5-11)30-20(21,22)23/h3-5,10,12-14,18H,6-9H2,1-2H3,(H2,24,show more
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SM1-71
CAS: 2088179-99-9 PubChem CID: 131801160 Formula: C₂₄H₂₆ClN₇O Peso molecolare: 463.96

≥96%

◐ .Su ordinazione · 8–12 settimane Oggetto #: S646519
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N-[2-[[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

SMILES

CN1CCN(CC1)C2=CC=C(C=C2)NC3=NC=C(C(=N3)NC4=CC=CC=C4NC(=O)C=C)Cl

InChIKey
SCMLGVPMSXTUNC-UHFFFAOYSA-N

InChI

1S/C24H26ClN7O/c1-3-22(33)28-20-6-4-5-7-21(20)29-23-19(25)16-26-24(30-23)27-17-8-10-18(11-9-17)32-14-12-31(2)13-15-32/h3-11,16H,1,12-15H2,2H3,(H,28,33show more
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GNE-3511
CAS: 1496581-76-0 PubChem CID: 72547959 Formula: C₂₃H₂₆F₂N₆O Peso molecolare: 440.49

Solido Moligand™ ? ≥99%

◐ .Su ordinazione · 8–12 settimane Oggetto #: G647232
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2-[[6-(3,3-difluoropyrrolidin-1-yl)-4-[1-(oxetan-3-yl)piperidin-4-yl]pyridin-2-yl]amino]pyridine-4-carbonitrile

SMILES

C1CN(CCC1C2=CC(=NC(=C2)N3CCC(C3)(F)F)NC4=NC=CC(=C4)C#N)C5COC5

InChIKey
RHFIAUKMKYHHFA-UHFFFAOYSA-N

InChI

1S/C23H26F2N6O/c24-23(25)4-8-31(15-23)22-11-18(17-2-6-30(7-3-17)19-13-32-14-19)10-21(29-22)28-20-9-16(12-26)1-5-27-20/h1,5,9-11,17,19H,2-4,6-8,13-15H2show more

Sinonimi
2-((6-(3,3-Difluoropyrrolidin-1-yl)-4-(1-(oxetan-3-yl)piperidin-4-yl)pyridin-2-yl)amino)isonicotinonitrile
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ASK1-IN-2
CAS: 2541792-70-3 PubChem CID: 155671000 Formula: C₁₉H₁₇FN₆O Peso molecolare: 364.38

≥98%

◐ .Su ordinazione · 8–12 settimane Oggetto #: A648376
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6-fluoro-N-[6-(4-propan-2-yl-1,2,4-triazol-3-yl)pyridin-2-yl]-1H-indole-2-carboxamide

SMILES

CC(C)N1C=NN=C1C2=NC(=CC=C2)NC(=O)C3=CC4=C(N3)C=C(C=C4)F

InChIKey
LYUQNMNUBOUCBX-UHFFFAOYSA-N

InChI

1S/C19H17FN6O/c1-11(2)26-10-21-25-18(26)14-4-3-5-17(23-14)24-19(27)16-8-12-6-7-13(20)9-15(12)22-16/h3-11,22H,1-2H3,(H,23,24,27)
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TAK1-IN-4
CAS: 1570374-32-1 Formula: C₁₈H₁₇N₃O₃ Peso molecolare: 323.35

≥99%

◐ .Su ordinazione · 8–12 settimane Oggetto #: T649901
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SMILES

O=C(C1=CC=CC(C(NC2=NC3=C(N2CCC)C=CC=C3)=O)=C1)O
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Cot inhibitor-2
CAS: 915363-56-3 PubChem CID: 44143370 Formula: C₂₆H₂₅Cl₂FN₈ Peso molecolare: 539.43

≥99%

◐ .Su ordinazione · 8–12 settimane Oggetto #: C650545
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8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethylpiperidin-4-yl)triazol-4-yl]methylamino]quinoline-3-carbonitrile

SMILES

CCN1CCC(CC1)N2C=C(N=N2)CNC3=CC4=C(C(=CN=C4C(=C3)Cl)C#N)NC5=CC(=C(C=C5)F)Cl

InChIKey
PHNZIIMWDVXPGG-UHFFFAOYSA-N

InChI

1S/C26H25Cl2FN8/c1-2-36-7-5-20(6-8-36)37-15-19(34-35-37)14-31-18-9-21-25(33-17-3-4-24(29)22(27)10-17)16(12-30)13-32-26(21)23(28)11-18/h3-4,9-11,13,15,show more

Sinonimi
BDBM29923 | 8-chloro-4-(3-chloro-4-fluoroanilino)-6-[[1-(1-ethylpiperidin-4-yl)triazol-4-yl]methylamino]quinoline-3-c...

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Domande frequenti

How is the MAP3K listing put together?

It draws on reported MAP3K annotations within MAPK/ERK Pathway and lists each compound with its structure, identifiers, and the activity published for it. Always check the underlying assay before comparing potency values across entries.

How do I choose a MAP3K modulator for my assay?

Start from the assay format and readout — biochemical, cell-based, or in vivo — then compare the MAP3K entries on potency, selectivity over related family members, and solubility in your vehicle. Where several chemotypes are available, a reference compound plus a structurally unrelated backup is the usual way to control for off-target effects.

Which specifications matter most for MAP3K compounds?

Purity and identity confirmation come first, then solubility in DMSO or your chosen vehicle, recommended storage temperature, and stability in solution. For MAP3K work in particular, freshly prepared stocks avoid most of the reproducibility problems seen with stored plates. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.

What if the MAP3K compound I need is not listed?

Search by CAS number or SMILES first, since analogs of MAP3K compounds are often catalogued under a related target. Custom synthesis and bulk enquiries go to [email protected]. We supply verified businesses, research institutions, universities, and government agencies.