Carboplatin - Moligand™, ≥98% , CAS No.41575-94-4

CAS: 41575-94-4 Cat. No.: C110682 Fórmula: C₆H₁₂N₂O₄Pt Peso molecular: 371.25 Número CE: 255-446-0

GRAU & PUREZA Moligand™, ≥98%

Synonyms

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) | 1,1-Cyclobutanedicarboxylatodiammineplatinum(II)

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Product Description
Carboplatin is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The development of carboplatin was inspired from the efficacy of its progenitor, Cisplatin (sc-200896), the first of this class of antineoplastic agents. The action of this group of platinum-based compounds is primarily attributed to DNA adduct formation, however, these molecules also bind other biological molecules, including enzymes, which might play a role in their mechanism of action.
An antitumor agent that binds to DNA leading to apoptosis

Product Application
Carboplatin has been used: in chemotherapy-induced thrombocytopenia mouse model and treatment to induce cell death in a large subset of colorectal cancer cells in the evaluation of cell proliferation and chemosensitivity 

as a positive control for suppressed cell growth

Product class
hAPIs, Metal based hAPIs

Chemical properties

Chemical formula

C6H12N2O4Pt

Empirical formula

[Pt(NH3)2(cbdc)]

Molecular weight

371.25

Metal

Pt

Theoretical metal content

53

Physical state

powder

Color

white

Especificações

Sinónimos

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II) | 1,1-Cyclobutanedicarboxylatodiammineplatinum(II)

Especificações e pureza

Moligand™, ≥98%

Mecanismos bioquímicos e fisiológicos

Carboplatin damages DNA by forming intrastrand cross-links with neighboring guanine residues. Tumors acquire resistance to these drugs through the loss of DNA-mismatch repair (MMR) activity and the resultant decrease in the induction of programmed cell de

Condições de armazenamento de armazenamento

Protected from light,Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nomes e identificadores

Pubchem Sid

508812646

Sorrisos canónicos

C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]

IUPAC Name

azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+)

InChIKey

VSRXQHXAPYXROS-UHFFFAOYSA-N

INCHI

1S/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H2;/q;2*-1;+2

SMILES isoméricas

C1CC(C1)(C(=O)O)C(=O)O.[NH2-].[NH2-].[Pt+2]

WGK Alemanha

3

RTECS

TP2300000

CAS alternativo

41575-94-4

Número NSC

201345

Termos de entrada MeSH

Blastocarb;Carboplat;Carboplatin;Carbosin;Carbotec;CBDCA;cis-Diammine(cyclobutanedicarboxylato)platinum II;Ercar;JM 8;JM-8;JM8;Nealorin;Neocarbo;NSC 241240;NSC-241240;NSC241240;Paraplatin;Paraplatine;Platinwas;Ribocarbo

Peso molecular

371.25

Reaxy-Rn

25079300

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25079300&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Classe Carboxylic acids and derivatives
      • Subclass Dicarboxylic acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Classe: Carboxylic acids and derivatives
• Subclass: Dicarboxylic acids and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Dicarboxylic acids and derivatives
• Alternative Parents: Organic transition metal salts Carboxylic acids Organic oxides Organic nitrogen compounds Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Dicarboxylic acid or derivatives - Organic transition metal salt - Carboxylic acid - Organic nitrogen compound - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organic salt - Organooxygen compound - Carbonyl group - Aliphatic homomonocyclic compound
• Descrição: This compound belongs to the class of organic compounds known as dicarboxylic acids and derivatives. These are organic compounds containing exactly two carboxylic acid groups.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propriedades químicas e físicas

• Solubilidade: Soluble in water.DMSO can inactivate Carboplatin's activity.
• Sensibilidade: Light sensitive.
• Ponto de fusão (°C): >275℃
• Peso molecular: 371.250 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 0
• Exact Mass: 371.045 Da
• Monoisotopic Mass: 371.045 Da
• Topological Polar Surface Area: 76.600 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 177.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 4

XLogP3