Dapirolizumab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1

Cat. No.: Ab191960

GRAU & PUREZA Animal Free, Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Application

Animal Model, ELISA, Flow Cytometry, Functional Assay

Host species

Human

Reactive species

Cynomolgus monkey, Human

Isotype

Human IgG1

Conjugation

Unconjugated

Visão geral

Dapirolizumab (anti-CD40L) is a monoclonal antibodi against CD40 ligand. Dapirolizumab (anti-CD40L) targets CD40L, blocks its interaction with CD40 receptors, and inhibits adaptive immune activation. Dapirolizumab (anti-CD40L) attenuates systemic lupus erythematosus.

Especificações

Product Name

Dapirolizumab (anti-CD40L) - Primary antibody, specific to CD40LG, Human IgG1

Sinónimos

CD154 antibody | CD40 antigen ligand antibody | CD40L antibody | CD40LG antibody | Gp39 antibody | HIGM1 antibody | Hyper IgM syndrome antibody | IGM antibody | IMD3 antibody | Ly62 antibody | T B cell activating molecule antibody | TBAM antibody | TNF re

Especificações e pureza

Carrier Free, Recombinant, ExactAb™, Low Endotoxin, Azide Free, Validated, Animal Free, ≥95%(SDS-PAGE&SEC-HPLC), See COA

Mecanismos bioquímicos e fisiológicos

The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper

Espécie hospedeira

Human

Especificidade

CD40LG

Conjugação

Unconjugated

Grau

Animal Free, Azide Free, Carrier Free, ExactAb™, Low Endotoxin, Recombinant, Validated

Isótipo

Human IgG1

Tipo de corrente de luz

kappa

SDS-PAGE

145 kDa

Método de purificação

Protein A purified

Concentração

See COA

Product Line

Produtos biológicos

Armazenamento e envio

Condições de armazenamento de armazenamento

Store at -80°C,Avoid repeated freezing and thawing

Enviado em

Dry ice packs + Cold packs

Estabilidade e armazenamento

Store at -80℃ for 24 months. Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle.

Imagens

Flow Cytometry: Dapirolizumab (anti-CD40L) (Ab191960)

Dapirolizumab (anti-CD40L) (Ab191960) - Flow Cytometry
Flow Cytometry analysis of unstimulated (left) or 500 ng/mL Ionomycin (I139530) and 10 ng/mL PMA (P408905) co-stimulated (right) Jurkat cells labelling CD40L (red) with Dapirolizumab (anti-CD40L) (Ab191960) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Human IgG (PE) (Ab175838) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, human IgG (Ab170213). Black - Unlabelled control, cells without incubation with primary antibody.

ELISA: Dapirolizumab (anti-CD40L) (Ab191960)

Dapirolizumab (anti-CD40L) (Ab191960) - ELISA
Immobilized Recombinant Human CD40 Ligand/TNFSF5 protein (rp189423) at 1.0 μg/mL can bind Dapirolizumab (anti-CD40L) (Ab191960) with the EC₅₀ of 28.88 ng/mL.

SEC: Dapirolizumab (anti-CD40L) (Ab191960)

Dapirolizumab (anti-CD40L) (Ab191960) - SEC
The purity of Dapirolizumab (anti-CD40L) (Ab191960) is more than 95% verified by HPLC.

Alvos associados (humanos)

CD40LG Tbio CD40 ligand (0 Activities)

Discover Target: CD40LG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mecanismos de ação