1-(4-Fluorophenethyl)piperazine: Properties, Uses & FAQs

1-(4-Fluorophenethyl)piperazine is a fluorinated piperazine derivative widely used as a building block and intermediate in medicinal chemistry and pharmaceutical research.

Chemical Name

1-(4-Fluorophenethyl)piperazine

SKU / Catalog Number

P725775

Core Structure

Piperazine ring N-substituted with a 4-fluorophenethyl group

Molecular Formula

C12H17FN2

Compound Class

Fluorinated piperazine derivative

Primary Application

Pharmaceutical intermediate and medicinal chemistry building block

What Is 1-(4-Fluorophenethyl)piperazine?

1-(4-Fluorophenethyl)piperazine (SKU: P725775) is an organic compound consisting of a piperazine ring bearing a 4-fluorophenethyl substituent on one of its nitrogen atoms. The molecular formula is C₁₂H₁₇FN₂. The incorporation of a fluorine atom on the phenyl ring is a common strategy in medicinal chemistry to modulate lipophilicity, metabolic stability, and binding affinity of drug candidates.

Piperazine-based scaffolds are found in numerous approved pharmaceuticals, and N-substituted piperazines such as this compound are frequently employed as intermediates in the synthesis of biologically active molecules. The phenethyl linker provides conformational flexibility between the aromatic ring and the piperazine core.

Handling, Storage, and Safety

As with all piperazine derivatives and amine-containing compounds, 1-(4-Fluorophenethyl)piperazine should be handled with appropriate personal protective equipment (PPE), including nitrile gloves, safety glasses, and a laboratory coat. Work should be performed in a well-ventilated area or fume hood to minimise inhalation exposure.

For optimal stability, the compound should be stored in a tightly sealed container, protected from moisture and light, at the temperature specified on the product label. Please consult the Safety Data Sheet (SDS) provided by Aladdin Scientific for full hazard classifications, first-aid measures, and disposal guidance before use.

Note: Specific GHS hazard classifications, recommended storage temperature, and flash point data for P725775 should be confirmed from the official SDS. Always follow your institution's chemical hygiene plan.

Research and Synthetic Applications

1-(4-Fluorophenethyl)piperazine serves primarily as a versatile building block in the synthesis of more complex molecules. Its free secondary amine (NH) on the unsubstituted piperazine nitrogen is reactive toward a broad range of electrophiles, enabling construction of di-N-substituted piperazines through acylation, alkylation, sulfonylation, and reductive amination reactions.

The 4-fluorophenyl motif is of particular interest in CNS drug discovery, receptor pharmacology studies, and the development of enzyme inhibitors, owing to fluorine's ability to improve membrane permeability and resist oxidative metabolism. Researchers have employed structurally related fluorophenethylpiperazines in studies targeting monoamine receptors, including dopamine and serotonin receptor subtypes.

Note: Specific literature citations for pharmacological studies involving this exact compound were not available in the source material and should be verified independently.

Ordering, Purity, and Quality Assurance

Aladdin Scientific supplies 1-(4-Fluorophenethyl)piperazine under catalog number P725775. Researchers should consult the product detail page for current specifications including purity grade, available quantities, and lot-specific certificate of analysis (CoA). Purity is typically assessed by techniques such as HPLC, GC, or NMR, and the CoA documents the analytical results for each production lot.

For bulk quantities, custom synthesis inquiries, or questions about specification grades, please contact Aladdin Scientific's technical support or sales team. Procurement teams should reference SKU P725775 on all purchase orders to ensure correct product identification.

Frequently asked questions

What is the molecular formula and structure of 1-(4-Fluorophenethyl)piperazine?

1-(4-Fluorophenethyl)piperazine has the molecular formula C12H17FN2. Its structure consists of a six-membered piperazine ring (containing two nitrogen atoms) with one nitrogen substituted by a 4-fluorophenethyl group (-CH2CH2-C6H4-F(para)), leaving the second ring nitrogen as a secondary amine available for further functionalization.

How should 1-(4-Fluorophenethyl)piperazine be stored to maintain stability?

The compound should be stored in a tightly sealed container, away from moisture, heat, and direct light. The precise recommended storage temperature (e.g., room temperature, 2–8 °C, or below –20 °C) should be confirmed from the product label and Safety Data Sheet for lot P725775, as specific conditions were not detailed in the available source material.

What reactions can be performed using the free NH of 1-(4-Fluorophenethyl)piperazine?

The secondary amine on the unsubstituted piperazine nitrogen is nucleophilic and can participate in a wide range of synthetic transformations, including acylation with acid chlorides or anhydrides, alkylation with alkyl halides, sulfonylation with sulfonyl chlorides, and reductive amination with aldehydes or ketones. These reactions allow chemists to rapidly build structurally diverse di-N-substituted piperazine libraries for medicinal chemistry programs.

Is 1-(4-Fluorophenethyl)piperazine suitable for biological assays directly, or is it mainly a synthetic intermediate?

This compound is primarily positioned as a building block and synthetic intermediate for the preparation of more complex target molecules in pharmaceutical and medicinal chemistry research. While structurally related compounds have been explored in receptor binding studies, researchers intending to use P725775 in biological assays should independently verify its suitability, purity requirements, and any relevant biological activity data from peer-reviewed literature.

How do I obtain a Certificate of Analysis (CoA) for lot P725775?

You can request a Certificate of Analysis for 1-(4-Fluorophenethyl)piperazine (P725775) directly through the Aladdin Scientific website product page using the lot number printed on your product label, or by contacting Aladdin Scientific customer service. The CoA will include analytical data such as purity, appearance, and identity confirmation relevant to your specific production lot.

References

1. Aladdin Scientific product page for 1-(4-Fluorophenethyl)piperazine, SKU P725775.
2. Müller K, Faeh C, Diederich F. Fluorine in pharmaceuticals: looking beyond intuition. Science. 2007;317(5846):1881-1886. doi:10.1126/science.1131943
3. Meanwell NA. Fluorine and fluorinated motifs in the design and application of bioisosteres for drug design. J Med Chem. 2018;61(14):5822-5880. doi:10.1021/acs.jmedchem.7b01788

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.