2-Nitro-4-methylsulphonyl-phenol: Handling & Lab Guidelines

2-Nitro-4-methylsulphonyl-phenol is a nitrophenol derivative bearing both a nitro and a methylsulphonyl substituent on the phenol ring, used as a key intermediate in agrochemical and fine-chemical synthesis.

CAS-based Compound Class

Nitrophenol / aryl sulfone derivative

Primary Application

Agrochemical intermediate and fine-chemical synthesis building block

Recommended Storage

Cool, dry, well-ventilated area away from heat sources and incompatible materials; follow SDS guidance

Product SKU

N694438 (Aladdin Scientific)

Functional Groups

Phenol –OH, nitro –NO₂, methylsulphonyl –SO₂CH₃

Physical State (typical)

Solid powder at room temperature (verify with product SDS)

Chemical Identity and Properties

2-Nitro-4-methylsulphonyl-phenol is an aromatic compound featuring a hydroxyl group at position 1, a nitro group (–NO₂) at position 2, and a methylsulphonyl group (–SO₂CH₃) at position 4 of the benzene ring. This combination of electron-withdrawing substituents renders the aromatic ring highly electron-deficient, which governs its reactivity in nucleophilic aromatic substitution and related transformations.

The compound is typically encountered as a solid at ambient temperature. Its melting point, exact molecular weight, and spectral data should be confirmed from the product-specific Certificate of Analysis (CoA) or Safety Data Sheet (SDS) supplied by Aladdin Scientific (SKU N694438). Researchers should consult these documents before use.

Key Applications in Research and Synthesis

2-Nitro-4-methylsulphonyl-phenol is principally valued as a synthetic intermediate in the preparation of agrochemicals, most notably herbicide active ingredients and related compounds. The methylsulphonyl group at the para position is an excellent leaving group under certain reaction conditions, enabling displacement by heteroatom nucleophiles to construct diverse aryl-ether or aryl-amine linkages.

In fine-chemical and medicinal chemistry contexts, the compound serves as a versatile electrophilic building block. Its electron-poor ring facilitates controlled functionalization, making it useful for the preparation of phenoxy-based compounds and sulphonyl-containing pharmacophores. Researchers exploring structure–activity relationships in herbicide design or developing new aryl sulphone scaffolds may find this reagent particularly applicable.

Note: Specific literature references for published applications should be verified independently. Aladdin Scientific does not warrant fitness for any undisclosed research purpose.

Storage, Handling, and Safety Guidelines

Storage: Store 2-Nitro-4-methylsulphonyl-phenol in a tightly sealed container in a cool, dry, and well-ventilated location. Keep away from heat, open flames, and incompatible materials such as strong oxidisers, strong bases, and reducing agents. Exposure to moisture or prolonged light should be minimised.

Personal Protective Equipment (PPE): When handling this compound, wear appropriate PPE including chemical-resistant gloves, a laboratory coat, and safety goggles. If dust generation is possible during weighing or transfer, use a fume hood and consider respiratory protection in accordance with local regulations.

Waste Disposal: Dispose of waste material in accordance with local, regional, and national regulations. Do not discharge to drains or the environment. Consult your institution's environmental health and safety (EHS) office for guidance specific to your jurisdiction.

First Aid: In case of skin or eye contact, flush immediately with copious amounts of water and seek medical advice. Refer to the SDS for the product (SKU N694438) for complete hazard and first-aid information before commencing work.

Quality, Purity, and Specification Considerations

For reproducible research results, reagent purity is a critical consideration. Aladdin Scientific supplies 2-Nitro-4-methylsulphonyl-phenol (SKU N694438) with a Certificate of Analysis (CoA) that specifies the purity, appearance, and relevant analytical data for each lot. Researchers are encouraged to download or request the lot-specific CoA prior to use.

Common analytical methods used to assess purity of such compounds include high-performance liquid chromatography (HPLC), gas chromatography (GC), nuclear magnetic resonance (NMR) spectroscopy, and melting-point determination. Discrepancies between expected and observed spectral data should be reported to Aladdin Scientific's technical support team.

Procurement teams should note that lot-to-lot consistency is maintained through Aladdin Scientific's quality management processes. For large-scale or GMP-adjacent research, contact Aladdin Scientific directly to discuss custom purity grades or bulk quantities.

Frequently asked questions

What is the primary use of 2-Nitro-4-methylsulphonyl-phenol in research?

It is primarily used as a synthetic intermediate in the preparation of agrochemicals, particularly herbicide active ingredients, and as a versatile electrophilic building block in fine-chemical and medicinal chemistry synthesis.

How should 2-Nitro-4-methylsulphonyl-phenol be stored to maintain stability?

Store the compound in a tightly sealed container in a cool, dry, and well-ventilated area, away from heat sources, open flames, and incompatible chemicals such as strong oxidisers and bases. Always refer to the product SDS for storage conditions specific to SKU N694438.

Where can I find purity and lot-specific data for SKU N694438?

Lot-specific purity and analytical data are available on the Aladdin Scientific website via the Certificate of Analysis (CoA) for SKU N694438. You can request the CoA directly from Aladdin Scientific's customer service team if it is not immediately available online.

What personal protective equipment is required when handling this compound?

At minimum, wear chemical-resistant gloves, a laboratory coat, and safety goggles. If dust is generated during weighing or transfer, work in a certified fume hood and consider respiratory protection. Consult the SDS for full PPE requirements.

Is 2-Nitro-4-methylsulphonyl-phenol available in custom quantities or purity grades?

For custom quantities, bulk orders, or higher purity grades, please contact Aladdin Scientific's sales or technical support team directly to discuss your specific requirements and availability.

References

1. Aladdin Scientific product page and Certificate of Analysis for 2-Nitro-4-methylsulphonyl-phenol, SKU N694438.
2. Safety Data Sheet (SDS) for 2-Nitro-4-methylsulphonyl-phenol, SKU N694438, Aladdin Scientific.
3. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure. Wiley-Interscience (textbook-level reference for nucleophilic aromatic substitution).

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.