Integrin beta 3/CD61 Mouse mAb - Primary antibody, specific to Integrin beta 3, Mouse IgG1

Cat. No.: Ab110877

GRADE & PURITY Carrier Free, Validated, ExactAb™, See COA

Application

Flow Cytometry

Host species

Mouse

Reactive species

Human

Isotype

Mouse IgG1

Clone Number

HIP11

Conjugation

Unconjugated

Visão geral

Mouse anti Human Integrin beta 3/CD61 Antibody, Monoclonal (HIP11), could be used for Flow and so on.
Application:
Flow:＜0.5 µg/100w cells
Protein Function
Integrin alpha-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin alpha-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Specifications

Product Name

Integrin beta 3/CD61 Mouse mAb - Primary antibody, specific to Integrin beta 3, Mouse IgG1

Sinónimos

BDPLT16 | BDPLT2 | BDPLT24 | GPIIIa | GT | GT2 | CD61 antigen | CD61 | GP3A | GP3Aplatelet glycoprotein IIIa | GPIIIaintegrin beta-3 | INGRB3 | Integrin beta 3 | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | ITG B3 | ITGB3 | Platelet membr

Especificações e pureza

Carrier Free, ExactAb™, Validated, See COA

Espécie hospedeira

Mouse

Especificidade

Integrin beta 3

Imunogénio

Normal peripheral blood platelets and platelets from IPT patients

Controlo positivo

Flow: Human peripheral blood lymphocytes.

Conjugação

Unconjugated

Grau

Carrier Free, ExactAb™, Validated

Isótipo

Mouse IgG1

Tipo de corrente de luz

kappa

SDS-PAGE

150 kDa

Método de purificação

Protein A purified

Concentração

See COA

Armazenamento e envio

Forma

Liquid

Condições de armazenamento de armazenamento

Store at 2-8°C

Enviado em

Wet ice

Estabilidade e armazenamento

Shipped at 4°C. Store at 4°C long term (36 months). Upon receipt, it is recommended to aliquot.

Imagens

Flow Cytometry: Integrin beta 3/CD61 Mouse mAb (Ab110877)

Integrin beta 3/CD61 Mouse mAb (Ab110877) - Flow Cytometry
Flow Cytometry analysis of human peripheral blood platelets labelling Integrin beta 3/CD61 (red) with Integrin beta 3/CD61 Mouse mAb (Ab110877) at 0.1 μg/mL for 1 hour at 4°C. Goat Anti-Mouse IgG (PE) (Ab179006) at a dilution of 1/1000 was used as the secondary antibody. Blue - Isotype control, mouse IgG (Ab170221). Black - Unlabelled control, cells without incubation with primary antibody.

Aplicação

• Aplicação: Dilution info
• Flow:

  < 0.5µg/100w cells;

Alvos associados (humanos)

ITGB3 Tclin Integrin beta-3 (0 Activities)

Discover Target: ITGB3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ITGB3 Tclin Integrin alpha-V/beta-3 (2708 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Integrin alpha-IIb/beta-3 (3481 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Fibronectin receptor (Integrin alpha-5/beta-1 and alpha-V/beta-3) (39 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Integrin alpha-V/beta-3 and alpha-IIb/beta 3 (49 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Integrin alpha-2/beta-3 (21 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ITGB3 Tclin Integrin alpha-3/beta-3 (47 Activities)

Discover Target: ITGB3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mecanismos de ação

Perguntas frequentes

What does ExactAb? mean?

ExactAb? indicates the product has been validated for use in rigorous antibody validation workflows. Validation may include positive/negative control samples, signal-to-noise testing, and protocol-specific QC. Lot-specific test data is published on the Certificate of Analysis where available.

What does Carrier Free mean?

Carrier Free indicates that the material has been processed and tested for specialty industrial processing. Specifications focus on the impurities that affect performance in that application — for example, metal content for electronics, particle size for batteries, refractive index for optics, or moisture content for moisture-sensitive processes.

How is this product shipped?

This product ships chilled on wet ice. Unpack on arrival and transfer it to the storage condition stated above.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.

Which species reactivity has this antibody been validated against?

Validated reactivity is listed on the PDP and on each lot's datasheet. We validate against the most commonly tested species for the target (Integrin beta 3/CD61 Mouse mAb); cross-reactivity in untested species may exist but is not guaranteed. Contact technical support for specific species inquiries.

How should this product be stored?

Store at 2–8 °C. Refrigerated storage is required to maintain the specified shelf life.