JH-RE-06 - ≥98% , CAS No.1361227-90-8

CAS: 1361227-90-8 Cat. No.: J414220 Fórmula: C₂₀H₁₆Cl₃N₃O₄ Peso molecular: 468.72

GRADE & PURITY ≥98%

Synonyms

4(1H)​-​Quinolinone,8-​chloro-​2-​[(2,​4-​dichlorophenyl)​amino]​-​3-​(3-​methyl-​1-​oxobutyl)​-​5-​nitro- | 8-Chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-4(1H)-quinolinone

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Visão geral

Information

JH-RE-06 JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).

Targets

REV1-REV7 (Cell-free assay); REV1-REV7 (Cell-free assay) 0.42 μM(Kd); 0.78 μM

In vitro

JH-RE-06 disrupts mutagenic TLS by preventing recruitment of mutagenic POL ζ. Remarkably, JH-RE-06 targets a nearly featureless surface of REV1 that interacts with the REV7 subunit of POL ζ. Binding of JH-RE-06 induces REV1 dimerization, which blocks the REV1-REV7 interaction and POL ζ recruitment. JH-RE-06 inhibits mutagenic TLS and enhances cisplatin-induced-toxicity in cultured human and mouse cell lines.

In vivo

JH-RE-06 improves tumor cell response to cisplatin in vivo. Co-administration of JH-RE-06 with cisplatin suppresses the growth of xenograft human melanomas in mice, establishing a framework for developing TLS inhibitors as a novel class of chemotherapy adjuvants.

Cell Research(from reference)

Cell lines：HT1080 cells, A375 cells, KP cells, MEF, LNCap cells, AG01522 cells. 

Concentrations：1.5 μM 

Incubation Time：24 h 

Specifications

Sinónimos

4(1H)​-​Quinolinone,8-​chloro-​2-​[(2,​4-​dichlorophenyl)​amino]​-​3-​(3-​methyl-​1-​oxobutyl)​-​5-​nitro- | 8-Chloro-2-[(2,4-dichlorophenyl)amino]-3-(3-methyl-1-oxobutyl)-5-nitro-4(1H)-quinolinone

Especificações e pureza

≥98%

Mecanismos bioquímicos e fisiológicos

JH-RE-06 is a potent REV1-REV7 interface inhibitor with an IC50 of 0.78 μM and Kd value of 0.42 μM, disrupting REV1-POL ζ-mediated mutagenic translesion synthesis (TLS).

Condições de armazenamento de armazenamento

Store at -20°C

Enviado em

Ice chest + Ice pads

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Pureza

≥98%

Propriedades do produto

ALogP

6.232

hba_count

2

Contagem HBD

2

Ligação rotativa

6

Nomes e identificadores

Sorrisos canónicos

CC(C)CC(=O)C1=C(NC2=CC=C(Cl)C=C2Cl)NC3=C(Cl)C=CC(=C3C1=O)[N+]([O-])=O

Peso molecular

468.72

Reaxy-Rn

22334922

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22334922&ln=

Propriedades químicas e físicas

• Solubilidade: Solubility (25°C) In vitro DMSO: 12 mg/mL (25.6 mM); Water: Insoluble; Ethanol: Insoluble
• DMSO (mg/mL) Solubilidade máxima: 12
• DMSO (mM) Solubilidade máxima: 25.6016385048643
• Água (mg/mL) Solubilidade máxima: ＜1

Perguntas frequentes

What is the purity of this product?

This product is supplied at ≥98% purity (chemical assay). Lot-specific values are stated on the Certificate of Analysis.

How should this product be stored?

Store at ?20 °C. Freezer storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships in an insulated container with ice pads. Unpack on arrival and transfer it to the storage condition stated above.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 1361227-90-8, the molecular formula is C20H16Cl3N3O4, and the molecular weight is 468.72 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.