Methazolamide - Moligand™, 10mM in DMSO , Inhibitor of carbonic anhydrase 1;Inhibitor of carbonic anhydrase 12;Inhibitor of carbonic anhydrase 14;Inhibitor of carbonic anhydrase 4;Inhibitor of carbonic anhydrase 7, CAS No.554-57-4, Inhibitor of carbonic anhydrase 1;Inhibitor of carbonic anhydrase 12;Inhibitor of carbonic anhydrase 14;Inhibitor of carbonic anhydrase 4;Inhibitor of carbonic anhydrase 7
Methazolamide - Moligand™, 10mM in DMSO , Inhibitor of carbonic anhydrase 1;Inhibitor of carbonic anhydrase 12;Inhibitor of carbonic anhydrase 14;Inhibitor of carbonic anhydrase 4;Inhibitor of carbonic anhydrase 7, CAS No.554-57-4, Inhibitor of carbonic anhydrase 1;Inhibitor of carbonic anhydrase 12;Inhibitor of carbonic anhydrase 14;Inhibitor of carbonic anhydrase 4;Inhibitor of carbonic anhydrase 7
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 3 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Visão geral
Information
Methazolamide (CL 8490) is acarbonic anhydraseinhibitor withKiof 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. In vitro
Methazolamide is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively. Methazolamide is of strength equal to acetazolamide, another carbonic anhydrase inhibitor used to treat irregular breathing disorders. However, methazolamide differs from acetazolamide in that it fails to activate Ca2+-dependent potassium channels in skeletal muscles.
In vivo
Methazolamide does not impair respiratory work performance in anesthetized rabbits. Cell Data
Methazolamide (CL 8490) is a carbonic anhydrase inhibitor with Ki of 50 nM, 14 nM and 36 nM for hCA I, hCA II and bCA IV isoforms, respectively.
Condições de armazenamento de armazenamento
Store at -80°C
Enviado em
Dry ice packs + Cold packs
Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.
Grau
Moligand™
Tipo de ação
INHIBITOR
Mecanismo de ação
Inhibitor of carbonic anhydrase 1;Inhibitor of carbonic anhydrase 12;Inhibitor of carbonic anhydrase 14;Inhibitor of carbonic anhydrase 4;Inhibitor of carbonic anhydrase 7
1.Junrong Li, Yingjun Wang, Ziqi Fan, Panyang Tang, Mengting Wu, Hong Xiao, Zhenxing Zeng. (2023) Toxicity of Tetracycline and Metronidazole in Chlorella pyrenoidosa. International Journal of Environmental Research and Public Health, 20 (4):(3623). [PMID:36834317][10.3390/ijerph20043623]
2.Da Wang, Zhe Yang, Yinning He, Shiwen Dong, Feilong Dong, Zhiqiao He, Xiaohui Lu, Lizhang Wang, Shuang Song, Jun Ma. (2022) Metribuzin and metamitron degradation using catalytic ozonation over tourmaline: Kinetics, degradation pathway, and toxicity. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:][10.1016/j.seppur.2022.123028]
3.Haojiang Wang, Wenli Hu, Qiong Zheng, Wei Bian, Zian Lin. (2017) One-pot preparation of mercaptotetrazole-silica hybrid monoliths by the thiol-ene click reaction for mixed-mode capillary liquid chromatography. JOURNAL OF SEPARATION SCIENCE, 40 (11):(2344-2354). [PMID:28374911][10.1002/jssc.201700220]
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