Spermidine - Moligand™, ≥99% , Channel blocker of K ir2.1;Channel blocker of K ir2.3, CAS No.124-20-9, Channel blocker of K ir2.1;Channel blocker of K ir2.3

Name: Spermidine - Moligand™, ≥99% , Channel blocker of K ir2.1;Channel blocker of K ir2.3, CAS No.124-20-9, Channel blocker of K ir2.1;Channel blocker of K ir2.3
SKU: S107071
Availability: InStock

CAS: 124-20-9 Cat. No.: S107071 Fórmula: C₇H₁₉N₃ Peso molecular: 145.25 Beilstein Registry Number: 1698591 Número CE: 204-689-0

58 Citations COA

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Spermidine - Moligand™, ≥99% CAS No(124-20-9) S107071 by Aladdin Scientific

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Disponível para encomenda

GRADE & PURITY Moligand™ ? ≥99%

Synonyms

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Visão geral Specifications Nomes e identificadores Documentation Advanced Data Taxonomic Classification Estrutura 3D Alvos associados (humanos) Alvos associados (não humanos) Mecanismos de ação Certificados（CoA,COO,BSE/TSE e Mapa de Análise) Propriedades químicas e físicas FAQs e artigos Citations of This Product Calculadoras de soluções Revisões

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Why this grade

Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 58 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Visão geral

Inhibits neuronal nitric oxide synthase (nNOS). Binds and precipitates DNA; may be used for purification of DNA binding proteins. Stimulates T4 polynucleotide kinase activity.

Product description

Spermidine, a natural biomolecule, is known for its wide-ranging health benefits, including anti-inflammatory effects, antioxidant properties, and improvements in respiratory function. It carries a positive charge at physiological pH, allowing it to interact with oppositely charged DNA and RNA. Dietary intake of spermidine is associated with a reduced risk of neurodegeneration, metabolic diseases, heart ailments, and cancer. Spermidine-induced autophagy has been shown to slow the rate of cognitive decline by clearing amyloid-beta plaques in the brain. Spermidine supplementation improves mitochondrial metabolism and translational activity. Moreover, spermidine exhibits cell-autonomous effects on cancer cells and influences their communication with immune effectors, leading to the acceleration of tumor-associated antigen identification and cancer cell death. Spermidine-mediated autophagy inhibits the activation of apoptosis in cancer cells and is linked to tissue development and cell differentiation. This natural compound is additionally recognized for its neuroprotective, and anti-aging properties and is naturally found in semen, as well as in various plant sources.
The enzyme nitric oxide synthase (nNOS) is involved in the production of nitric oxide.
Purpose
Spermidine has been used:
in the preparation of 5x transcription buffer
in the treatment of double-stranded RNA along with other reagents to increase the uptake of dsRNA by nematodes
as a standard in the analytical study of rat brain polyamines (185)

Specifications

Sinónimos

Especificações e pureza

Moligand™, ≥99%

Mecanismos bioquímicos e fisiológicos

Inhibit neuronal nitric oxide synthase (nNOS). Binding and precipitation of DNA can be used for purification of DNA binding proteins. Activate T4 polynucleotide kinase activity. Inhibit neuronal nitric oxide synthase (nNOS). Combining and precipitating DN

Condições de armazenamento de armazenamento

Store at 2-8°C,Argon charged

Enviado em

Wet ice

Este produto requer transporte de cadeia fria. Serviços terrestres e outros serviços econômicos não estão disponíveis.

Grau

Moligand™

Tipo de ação

CHANNEL BLOCKER

Mecanismo de ação

Channel blocker of K ir2.1;Channel blocker of K ir2.3

Pureza

≥99%

Nomes e identificadores

Pubchem Sid

508812388

Sorrisos canónicos

NCCCCNCCCN

IUPAC Name

N'-(3-aminopropyl)butane-1,4-diamine

InChIKey

ATHGHQPFGPMSJY-UHFFFAOYSA-N

INCHI

1S/C7H19N3/c8-4-1-2-6-10-7-3-5-9/h10H,1-9H2

SMILES isoméricas

C(CCNCCCN)CN

WGK Alemanha

Número UN

2735

Peso molecular

145.25

Beilstein

1698591

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organic nitrogen compounds
  - Classe Organonitrogen compounds
    - Subclass Amines
      - Level5 Secondary amines
        Level6 Dialkylamines

Kingdom	Organic compounds
Superclass	Organic nitrogen compounds
Classe	Organonitrogen compounds
Subclass	Amines
Intermediate Tree Nodes	Secondary amines
Direct Parent	Dialkylamines
Alternative Parents	Organopnictogen compounds Monoalkylamines Hydrocarbon derivatives
Molecular Framework	Aliphatic acyclic compounds
Substituents	Secondary aliphatic amine - Organopnictogen compound - Hydrocarbon derivative - Primary amine - Primary aliphatic amine - Aliphatic acyclic compound
Descrição	This compound belongs to the class of organic compounds known as dialkylamines. These are organic compounds containing a dialkylamine group, characterized by two alkyl groups bonded to the amino nitrogen.
External Descriptors	triamine - polyazaalkane
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

Estrutura 3D

Alvos associados (humanos)

KCNJ4 Tchem Inward rectifier potassium channel 4 (0 Activities)

Discover Target: KCNJ4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

KCNJ2 Tchem Inward rectifier potassium channel 2 (1 Activities)

Discover Target: KCNJ2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA4 Tclin Carbonic anhydrase 4 (1 Activities)

Discover Target: CA4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA14 Tclin Carbonic anhydrase 14 (1 Activities)

Discover Target: CA14

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CA2 Tclin Carbonic anhydrase II (17698 Activities)

Discover Target: CA2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

Discover Target: CHRM1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TOP2A Tclin DNA topoisomerase II alpha (6317 Activities)

Discover Target: TOP2A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

TSHR Tclin Thyroid stimulating hormone receptor (29986 Activities)

Discover Target: TSHR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ODC1 Tclin Ornithine decarboxylase (70 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA3 Tclin Carbonic anhydrase III (753 Activities)

Discover Target: CA3

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA6 Tclin Carbonic anhydrase VI (993 Activities)

Discover Target: CA6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA1 Tclin Carbonic anhydrase I (13240 Activities)

Discover Target: CA1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

PAOX Tchem Polyamine oxidase (84 Activities)

Discover Target: PAOX

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15B Tchem Arachidonate 15-lipoxygenase, type II (7244 Activities)

Discover Target: ALOX15B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA5B Tclin Carbonic anhydrase VB (957 Activities)

Discover Target: CA5B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA5A Tclin Carbonic anhydrase VA (1168 Activities)

Discover Target: CA5A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA14 Tclin Carbonic anhydrase XIV (1305 Activities)

Discover Target: CA14

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2D6 Tclin Cytochrome P450 2D6 (33882 Activities)

Discover Target: CYP2D6

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

MTOR Tclin Serine/threonine-protein kinase mTOR (13850 Activities)

Discover Target: MTOR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

AMD1 Tchem S-adenosylmethionine decarboxylase 1 (215 Activities)

Discover Target: AMD1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ALOX15 Tchem Arachidonate 15-lipoxygenase (7108 Activities)

Discover Target: ALOX15

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA12 Tclin Carbonic anhydrase XII (6231 Activities)

Discover Target: CA12

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP1A2 Tchem Cytochrome P450 1A2 (26471 Activities)

Discover Target: CYP1A2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C9 Tchem Cytochrome P450 2C9 (32119 Activities)

Discover Target: CYP2C9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP2C19 Tchem Cytochrome P450 2C19 (29246 Activities)

Discover Target: CYP2C19

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CA9 Tclin Carbonic anhydrase IX (8255 Activities)

Discover Target: CA9

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

CYP3A4 Tclin Cytochrome P450 3A4 (53859 Activities)

Discover Target: CYP3A4

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Homo sapiens (32628 Activities)

Lot Number	Certificate Type	Data	Item
J2211049	Certificate of Analysis	Jul 03, 2026	S107071
J2211017	Certificate of Analysis	Jul 03, 2026	S107071
F2612524	Certificate of Analysis	May 20, 2026	S107071
F2612511	Certificate of Analysis	May 20, 2026	S107071
F2612510	Certificate of Analysis	May 20, 2026	S107071
F2612508	Certificate of Analysis	May 20, 2026	S107071
F2612507	Certificate of Analysis	May 20, 2026	S107071
D2629005	Certificate of Analysis	Nov 21, 2025	S107071
K2506602	Certificate of Analysis	Nov 17, 2025	S107071
K2506603	Certificate of Analysis	Nov 17, 2025	S107071
K2506605	Certificate of Analysis	Nov 17, 2025	S107071
K2506604	Certificate of Analysis	Nov 17, 2025	S107071
H2118334	Certificate of Analysis	Jun 09, 2025	S107071
F2517714	Certificate of Analysis	Jun 07, 2025	S107071
F2517715	Certificate of Analysis	Jun 07, 2025	S107071
B2605017	Certificate of Analysis	Jun 07, 2025	S107071
F2517701	Certificate of Analysis	Jun 07, 2025	S107071
D2412193	Certificate of Analysis	Mar 09, 2024	S107071
C2406034	Certificate of Analysis	Sep 05, 2022	S107071
K2422260	Certificate of Analysis	Sep 05, 2022	S107071
K2422245	Certificate of Analysis	Sep 05, 2022	S107071
K2407156	Certificate of Analysis	Sep 05, 2022	S107071
J2324034	Certificate of Analysis	Sep 05, 2022	S107071
J2211048	Certificate of Analysis	Sep 05, 2022	S107071
J2211016	Certificate of Analysis	Sep 05, 2022	S107071
H2421105	Certificate of Analysis	Sep 05, 2022	S107071
H2408061	Certificate of Analysis	Sep 05, 2022	S107071
G2424018	Certificate of Analysis	Sep 05, 2022	S107071
C2428026	Certificate of Analysis	Sep 05, 2022	S107071
D2502081	Certificate of Analysis	Sep 05, 2022	S107071
D2502083	Certificate of Analysis	Sep 05, 2022	S107071
F2426251	Certificate of Analysis	Sep 05, 2022	S107071
G2220406	Certificate of Analysis	Jul 22, 2022	S107071
C2225006	Certificate of Analysis	Jun 01, 2022	S107071
C2225062	Certificate of Analysis	May 25, 2022	S107071
H2218071	Certificate of Analysis	Aug 13, 2021	S107071

Solubilidade	Miscible with water, ethanol and ether.
Sensibilidade	Air & moisture sensitive;Hygroscopic
Índice de refração	1.4785-1.4805
Ponto de inflamação (°F)	230°F
Ponto de inflamação (°C)	>110°
Ponto de ebulição (°C)	128-130°C
Ponto de fusão (°C)	22-25°C
Peso molecular	145.250 g/mol
XLogP3	-1.000
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	7
Exact Mass	145.158 Da
Monoisotopic Mass	145.158 Da
Topological Polar Surface Area	64.099 Å²
Heavy Atom Count	10
Formal Charge	0
Complexity	56.800
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Spermidine - Moligand™, ≥99% , Channel blocker of K ir2.1;Channel blocker of K ir2.3, CAS No.124-20-9, Channel blocker of K ir2.1;Channel blocker of K ir2.3

Storage & shipping

Quality documents

Literature proof

Visão geral

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

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