6-HidroxidopaminaHidrocloruro - Moligand™,≥95% , CAS No.28094-15-7

CAS: 28094-15-7 Cat. No.: H754215 Peso molecular: 205.64 Beilstein Registry Number: 4274007 Número EC: 248-837-2

GRADE & PURITY Moligand™, ≥95%

Synonyms

clorhidrato de 2,4,5-Trihidroxifenetilamina | Clorhidrato de 2,5-Dihidroxitiramina | Clorhidrato de 2-(2,4,5-Trihidroxifenil)etilamina | 6-OHDA

Storage

Conservar a 2-8°C,Protegido de la luz,Cargado con argón

Shipped In

Hielo húmedo

Descripción general

el clorhidrato de 6-hidroxidopamina es una neurotoxina catecolaminérgica selectiva. el clorhidrato de 6-hidroxidopamina reduce los niveles cerebrales de catecolaminas por captación y acumulación mediante un mecanismo de transporte específico de estas neuronas. Provoca la destrucción casi completa de las neuronas dopaminérgicas nigrales y sus terminales estriatales cuando se inyecta en la sustancia negra de ratas, produciendo un modelo animal de la enfermedad de Parkinson.
Neurotoxina catecolaminérgica selectiva.

Specifications

Sinónimos

clorhidrato de 2, 4, 5-Trihidroxifenetilamina | Clorhidrato de 2, 5-Dihidroxitiramina | Clorhidrato de 2-(2, 4, 5-Trihidroxifenil)etilamina | 6-OHDA

Especificaciones y pureza

Moligand™, ≥95%

Mecanismos bioquímicos y fisiológicos

Neurotoxina que destruye los terminales catecolaminérgicos.

Condiciones de almacenamiento de almacenamiento

Conservar a 2-8°C, Protegido de la luz, Cargado con argón

Enviado en

Hielo húmedo

Grado

Moligand™

Tipo de acción

ACTIVATOR

Pureza

≥95%

Nombres e identificadores

• Sonrisas canónicas: C1=C(C(=CC(=C1O)O)O)CCN.Cl
• IUPAC Name: 5-(2-aminoethyl)benzene-1,2,4-triol;hydrochloride
• InChIKey: QLMRJHFAGVFUAC-UHFFFAOYSA-N
• INCHI: 1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
• Isómeros SMILES: C1=C(C(=CC(=C1O)O)O)CCN.Cl
• WGK Alemania: 3
• RTECS: DC4650000
• Peso molecular: 205.64
• Beilstein: 4274007
• Reaxy-Rn: 4274007
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4274007&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Phenols
      • Subclass Benzenediols
        • Level5 Catechols
          • Level6 Catecholamines and derivatives

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Phenols
• Subclass: Benzenediols
• Intermediate Tree Nodes: Catechols
• Direct Parent: Catecholamines and derivatives
• Alternative Parents: Phenethylamines Hydroxyquinols and derivatives 2-arylethylamines Aralkylamines 1-hydroxy-2-unsubstituted benzenoids Polyols Organopnictogen compounds Monoalkylamines Hydrochlorides Hydrocarbon derivatives
• Molecular Framework: Aromatic homomonocyclic compounds
• Substituents: Catecholamine - Hydroxyquinol derivative - Phenethylamine - 2-arylethylamine - 1-hydroxy-2-unsubstituted benzenoid - Aralkylamine - Monocyclic benzene moiety - Polyol - Primary amine - Amine - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrochloride - Aromatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as catecholamines and derivatives. These are compounds containing 4-(2-Aminoethyl)pyrocatechol [4-(2-aminoethyl)benzene-1,2-diol] or a derivative thereof formed by substitution.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in water (>50 mg/ml).
• Sensibilidad: Hygroscopic；Light sensitive
• Punto de fusión (°C): 232-233 °C
• Peso molecular: 205.640 g/mol
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 205.051 Da
• Monoisotopic Mass: 205.051 Da
• Topological Polar Surface Area: 86.700 Ų
• Heavy Atom Count: 13
• Formal Charge: 0
• Complexity: 142.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

1. Jiezhou Pan, Haotian Liao, Guidong Gong, Yunxiang He, Qin Wang, Lang Qin, Yaoyao Zhang, Hirotaka Ejima, Blaise L. Tardy, Joseph J. Richardson, Jiaojiao Shang, Orlando J. Rojas, Yong Zeng, Junling Guo.  (2023)  Supramolecular nanoarchitectonics of phenolic-based nanofiller for controlled diffusion of versatile drugs in hydrogels.  JOURNAL OF CONTROLLED RELEASE,      [PMID:37422124] [10.1016/j.jconrel.2023.07.003]

2. Yanlin Chen, Gang Zheng, Yujie Bian, Haiwei Ma, Chenqiang Jin, Zhichao Hu, Haohan Su, Xinli Hu, Zhiyong Qian, Liyan Shen, Wenfei Ni.  (2022)  Hybrid multilayer coating as the psoralen delivery vehicle promoting bone regeneration on titanium mesh scaffolds in a Posterolateral Spinal Fusion model.  Applied Materials Today,      [PMID:] [10.1016/j.apmt.2022.101530]