A 804598 - Moligand™, ≥98% , Antagonist of P2X7, CAS No.1125758-85-1, Antagonist of P2X7

CAS: 1125758-85-1 Cat. No.: A287786 Peso molecular: 315.37 Número EC: 802-550-4

GRADE & PURITY Moligand™, ≥98%

Synonyms

N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine | A-804598 | N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

N-Cyano-N"-[(1S)-1-phenylethyl]-N'-5-quinolinyl-guanidine | A-804598 | N-Cyano-N′′-[(1S)-1-phenylethyl]-N′-5-quinolinyl-guanidine

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Potent, competitive P2X7receptor antagonist (IC50values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7receptors respectively). Selective for P2X7receptors (IC50> 5-10μM for a wide array of cell surface receptors and ion channels). Binds with high

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ANTAGONIST

Mecanismo de acción

Antagonist of P2X7

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504771149
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504771149
• Sonrisas canónicas: CC(C1=CC=CC=C1)N=C(NC#N)NC2=CC=CC3=C2C=CC=N3
• IUPAC Name: 1-cyano-2-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine
• InChIKey: PQYCRDPLPKGSME-AWEZNQCLSA-N
• INCHI: 1S/C19H17N5/c1-14(15-7-3-2-4-8-15)23-19(22-13-20)24-18-11-5-10-17-16(18)9-6-12-21-17/h2-12,14H,1H3,(H2,22,23,24)/t14-/m0/s1
• Isómeros SMILES: C[C@@H](C1=CC=CC=C1)N=C(NC#N)NC2=CC=CC3=C2C=CC=N3
• Peso molecular: 315.37
• Reaxy-Rn: 31636225
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=31636225&ln=

Objetivos asociados (humanos)

P2RX7 Tchem P2X purinoceptor 7 (4 Activities)

Discover Target: P2RX7

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solvent:DMSO, Max Conc. mg/mL: 31.54, Max Conc. mM: 100
• Peso molecular: 315.400 g/mol
• XLogP3: 4.000
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 315.148 Da
• Monoisotopic Mass: 315.148 Da
• Topological Polar Surface Area: 73.100 Ų
• Heavy Atom Count: 24
• Formal Charge: 0
• Complexity: 473.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1