Ac-WEHD-AMC, TFA salt - BioReagent, ≥98% , CAS No.189275-74-9 (free base)

CAS: 189275-74-9 (free base) Cat. No.: A1456354 Peso molecular: 784.8 (free base)

GRADE & PURITY BioReagent, ≥98%

Synonyms

Caspase-1 Substrate X, Fluorogenic | Caspase-5 Substrate III, Fluorogenic | Ac-Trp-Glu-His-Asp-AMC | Ac-Trp-Glu-His-{Asp-AMC}

Storage

Protected from light,Store at -20°C,Desiccated,Avoid repeated freezing and thawing

Shipped In

Ice chest + Ice pads

Application

Apoptosis, Cell signaling, Drug screening, Enzyme activity assay

Descripción general

Ac-WEHD-AMC is a potent fluorescent substrate for caspase-1.

Applications and Functions

1. Caspase-1 Enzyme Activity Detection

Ac-WEHD-AMC serves as a specific substrate for caspase-1 (a cysteine protease involved in the cell apoptosis process). When caspase-1 is present, it cleaves the peptide bond in Ac-WEHD-AMC, releasing the fluorescent group AMC. The enzyme activity of caspase-1 can then be detected by monitoring changes in fluorescence intensity. This method is widely used in research on biological processes such as cell apoptosis and inflammatory responses.

2. Drug Screening and Development

Due to the specific interaction between Ac-WEHD-AMC and caspase-1, it can be used to screen and develop inhibitors or agonists targeting caspase-1. Such compounds hold potential for treating diseases like neurodegenerative disorders and autoimmune diseases.

3. Biomedical and Molecular Biology Research

Ac-WEHD-AMC also functions as a tool compound in biochemical and molecular biological studies, aiding in the exploration of caspase-1’s roles and mechanisms in biological processes such as cell signaling and protein degradation.

Specifications

Sinónimos

Caspase-1 Substrate X, Fluorogenic | Caspase-5 Substrate III, Fluorogenic | Ac-Trp-Glu-His-Asp-AMC | Ac-Trp-Glu-His-{Asp-AMC}

Especificaciones y pureza

BioReagent, ≥98%

Estabilidad y almacenamiento

Store at -20℃ long term (24 months). Upon receipt, it is recommended to aliquot. Avoid freeze/thaw cycle. Store in the dark. Desiccated

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Desiccated, Avoid repeated freezing and thawing

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

BioReagent

Pureza

≥98%

Nombres e identificadores

• Peso molecular: 784.8 (free base)

Propiedades químicas y físicas

• Solubilidad: Soluble in 10% ACN/H2O.