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· · COA & SDS Disponible para cada producto · Same-day shipping on in-stock items Aliskiren Hemifumarate - ≥98% , Renin inhibitor, CAS No.173334-58-2, Renin inhibitor
Synonyms
CHEBI:141362 | SCHEMBL187762 | ALISKIREN HEMIFUMARATE [MI] | AMTURNIDE COMPONENT ALISKIREN HEMIFUMARATE | Aliskiren fumarate (JAN/USAN) | NSC-759185 | RASITRIO COMPONENT ALISKIREN HEMIFUMARATE | CCG-270658 | STL557239 | AKOS015896419 | UNII-C8A0P8G029 | (
Shipped In
Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general Aliskiren hemifumarate is a direct renin inhibitor with IC50 of 1.5 nM.
Specifications Sinónimos
CHEBI:141362 | SCHEMBL187762 | ALISKIREN HEMIFUMARATE [MI] | AMTURNIDE COMPONENT ALISKIREN HEMIFUMARATE | Aliskiren fumarate (JAN/USAN) | NSC-759185 | RASITRIO COMPONENT ALISKIREN HEMIFUMARATE | CCG-270658 | STL557239 | AKOS015896419 | UNII-C8A0P8G029 | (
Especificaciones y pureza
≥98%
Mecanismos bioquímicos y fisiológicos
Potent renin inhibitor (IC50= 0.6 and 80 nM for human and rat respectively). Exhibits selectivity for renin over a range of other aspartic proteinases (>5000 nM). Lowers blood pressure in a hypertensive rodent model. Orally active.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Mecanismo de acción
Renin inhibitor
Nombres e identificadores Pubchem Sid 488195878 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/488195878 Sonrisas canónicas CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)C(CC1=CC(=C(C=C1)OC)OCCCOC)CC(C(CC(C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=CC(=O)O)C(=O)O IUPAC Name (2S,4S,5S,7S)-5-amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-4-hydroxy-7-[[4-methoxy-3-(3-methoxypropoxy)phenyl]methyl]-8-methyl-2-propan-2-ylnonanamide;(E)-but-2-enedioic acid InChIKey KLRSDBSKUSSCGU-KRQUFFFQSA-N INCHI 1S/2C30H53N3O6.C4H4O4/c2*1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36;5-3(6)1-2-4(7)8/h2*10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35);1-2H,(H,5,6)(H,7,8)/b;;2-1+/t2*22-,23-,24-,25-;/m00./s1 Isómeros SMILES CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.CC(C)[C@@H](CC1=CC(=C(C=C1)OC)OCCCOC)C[C@@H]([C@H](C[C@@H](C(C)C)C(=O)NCC(C)(C)C(=O)N)O)N.C(=C/C(=O)O)\C(=O)O PubChem CID 6918427 Peso molecular 609.83
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organic acids and derivatives Clase Carboxylic acids and derivatives Subclass Amino acids, peptides, and analogues Intermediate Tree Nodes Amino acids and derivatives Direct Parent Delta amino acids and derivatives Alternative Parents Beta amino acids and derivatives Phenylbutylamines Anisoles Methoxybenzenes Phenoxy compounds Alkyl aryl ethers Aralkylamines N-acyl amines Dicarboxylic acids and derivatives Unsaturated fatty acids 1,2-aminoalcohols Secondary carboxylic acid amides Primary carboxylic acid amides Secondary alcohols Dialkyl ethers Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds Molecular Framework Not available Substituents Delta amino acid or derivatives - Phenylbutylamine - Beta amino acid or derivatives - Phenoxy compound - Anisole - Methoxybenzene - Phenol ether - Alkyl aryl ether - Aralkylamine - Fatty acid - Benzenoid - Unsaturated fatty acid - Dicarboxylic acid or derivatives - Fatty amide - N-acyl-amine - Fatty acyl - Monocyclic benzene moiety - 1,2-aminoalcohol - Carboxamide group - Secondary carboxylic acid amide - Secondary alcohol - Primary carboxylic acid amide - Ether - Dialkyl ether - Carboxylic acid - Amine - Organic nitrogen compound - Hydrocarbon derivative - Alcohol - Carbonyl group - Organic oxide - Organopnictogen compound - Primary aliphatic amine - Organic oxygen compound - Organonitrogen compound - Organooxygen compound - Primary amine - Aromatic homomonocyclic compound Descripción This compound belongs to the class of organic compounds known as delta amino acids and derivatives. These are compounds containing a carboxylic acid group and an amino group at the C5 carbon atom. External Descriptors fumarate salt Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
Estructura 3D Objetivos asociados (humanos) Objetivos asociados (no humanos) Mecanismos de acción Certificados (CoA, COO, BSE/TSE y tabla de análisis) Propiedades químicas y físicas Solubilidad Solvent:water, Max Conc. mg/mL: 60.98, Max Conc. mM: 100; Solvent:DMSO, Max Conc. mg/mL: 60.98, Max Conc. mM: 100 Sensibilidad Heat, light sensitive Peso molecular 1219.600 g/mol XLogP3 Hydrogen Bond Donor Count 10 Hydrogen Bond Acceptor Count 18 Rotatable Bond Count 40 Exact Mass 1218.8 Da Monoisotopic Mass 1218.8 Da Topological Polar Surface Area 367.000 Ų Heavy Atom Count 86 Formal Charge 0 Complexity 836.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 8 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 1 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 1 Covalently-Bonded Unit Count 3
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