Aloxistatin (E64d) - Moligand™, 10mM in DMSO , Inhibitor of cathepsin G, CAS No.88321-09-9, Inhibitor of cathepsin G

CAS: 88321-09-9 Cat. No.: A409190 Peso molecular: 342.43 Número EC: 635-831-3

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

E-64d | 3-​[[[(1S)-​3-​methyl-​1[[(3S-​methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-​2S-​oxiranecarboxylic acid,​ ethyl ester

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Aloxistatin (E64d) Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin tr
In vitro

Aloxistatin can enter the intact platelet and inhibit proteolysis by inhibiting calpain. Aloxistatin blunts Parathyroid hormone (PTH)-induced cell proliferation and inhibits differentiation osteoblasts in vitro.

In vivo

Aloxistatin (100 mg/kg, p.o.) strongly inhibits the cathepsin B&L activities in the skeletal muscle, heart and liver of hamsters. In spinal cord injury (SCI) rats, Aloxistatin provides neuroprotection in SCI lesion and penumbra. Aloxistatin reduces brain amyloid-β and improves memory deficits in Alzheimer\'s disease animal models by inhibiting cathepsin B activity.
Cell Data

cell lines：PTC cells

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinónimos

E-64d | 3-​[[[(1S)-​3-​methyl-​1[[(3S-​methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-​2S-​oxiranecarboxylic acid, ​ ethyl ester

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Aloxistatin (E64d) is an irreversible and membrane-permeable cysteine protease inhibitor with blood platelet aggregation inhibiting activity. The cysteine protease cathepsin L is required for SARS-CoV-2 viral entry, and aloxistatin treatment reduced cellu

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of cathepsin G

Nombres e identificadores

• Isómeros SMILES: CCOC(=O)[C@@H]1[C@H](O1)C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
• Peso molecular: 342.43
• Reaxy-Rn: 25759192
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25759192&ln=

Objetivos asociados (humanos)

CTSG Tchem Cathepsin G (0 Activities)

Discover Target: CTSG

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 100 mg/mL (158.31 mM); Ethanol: 40 mg/mL (63.32 mM); Water: Insoluble
• Rotación específica [α]: 49° (C=1,MeOH)
• Punto de fusión (°C): 126 °C

Referencias

1. Fang Shi, Yong-Sheng Gao, Shu-Mei Han, Cheng-Suo Huang, Qing-Sheng Hou, Xiao-wen Wen, Ben-Shi Wang, Zhen-Yu Zhu, Lei Zou.  (2024)  Allulose mitigates chronic enteritis by reducing mitochondria dysfunction via regulating cathepsin B production.  INTERNATIONAL IMMUNOPHARMACOLOGY,      [PMID:38354512] [10.1016/j.intimp.2024.111645]

2. Shao-Yan Shen, Ming Ma, Chen Bai, Wei-Qing Wang, Rui-Bin Zhu, Qiong Gao, Xian-Jun Song.  (2024)  Optimizing rice grain size by attenuating phosphorylation-triggered functional impairment of a chromatin modifier ternary complex.  DEVELOPMENTAL CELL,      [PMID:38237589] [10.1016/j.devcel.2023.12.013]

3. Cheng-Bao Ma, Chen Liu, Young-Jun Park, Jingjing Tang, Jing Chen, Qing Xiong, Jimin Lee, Cameron Stewart, Daniel Asarnow, Jack Brown, M. Alejandra Tortorici, Xiao Yang, Ye-Hui Sun, Yuan-Mei Chen, Xiao Yu, Jun-Yu Si, Peng Liu, Fei Tong, Mei-Ling Huang, Jing Li, Zheng-Li Shi, Zengqin Deng, David Veesler, Huan Yan.  (2025)  Multiple independent acquisitions of ACE2 usage in MERS-related coronaviruses.  CELL,      [PMID:39922191] [10.1016/j.cell.2024.12.031]