The core question in targeted protein degradation is: “Can the cell be made to remove this protein, and can the removal process be proven to follow the expected mechanism?” Cellular protein levels are jointly regulated by synthesis, folding, localization, and degradation. The two systems ...
The anticancer drug Lenalidomide was once one of the world's top-selling small molecule drugs and orphan drugs, with sales of up to 9.978 billion US dollars in 2022, and its development company Celgene made huge profits.
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