Anhydrotetracycline hydrochloride - Moligand™, ≥98% , CAS No.13803-65-1

CAS: 13803-65-1 Cat. No.: A276282 Peso molecular: 462.88 Número EC: 893-173-4

GRADE & PURITY Moligand™, ≥98%

Synonyms

2-NAPHTHACENECARBOXAMIDE, 4-(DIMETHYLAMINO)-1,4,4A,5,12,12A-HEXAHYDRO-3,10,11,12A-TETRAHYDROXY-6-METHYL-1,12-DIOXO-, MONOHYDROCHLORIDE | 4-(Dimethylamino)-1,4,4a,5,12,12a-hexahydro-3,10,11,12a-tetrahydroxy-6-methyl-1,12-dioxo-2-naphthacenecarboxamide mono

Storage

Protected from light,Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Specifications

Sinónimos

2-NAPHTHACENECARBOXAMIDE, 4-(DIMETHYLAMINO)-1, 4, 4A, 5, 12, 12A-HEXAHYDRO-3, 10, 11, 12A-TETRAHYDROXY-6-METHYL-1, 12-DIOXO-, MONOHYDROCHLORIDE | 4-(Dimethylamino)-1, 4, 4a, 5, 12, 12a-hexahydro-3, 10, 11, 12a-tetrahydroxy-6-methyl-1, 12-dioxo-2-naphthacenecarboxamide mono

Especificaciones y pureza

Moligand™, ≥98%

Mecanismos bioquímicos y fisiológicos

Anhydrotetracycline hydrochloride, a tetracycline biosynthetic precursor, is a potent competitive broad-spectrum tetracycline destructase enzymes inhibitor. Anhydrotetracycline hydrochloride is an effector for tetracycline controlled gene expression syste

Condiciones de almacenamiento de almacenamiento

Protected from light, Store at -20°C, Desiccated

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Nota

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Pureza

≥98%

Nombres e identificadores

• Sonrisas canónicas: CC1=C2C=CC=C(C2=C(C3=C1CC4C(C(=O)C(=C(C4(C3=O)O)O)C(=O)N)N(C)C)O)O.Cl
• IUPAC Name: (4S,4aS,12aR)-4-(dimethylamino)-1,10,11,12a-tetrahydroxy-6-methyl-3,12-dioxo-4a,5-dihydro-4H-tetracene-2-carboxamide;hydrochloride
• InChIKey: SPFAOPCHYIJPHJ-WPJNXPDPSA-N
• INCHI: 1S/C22H22N2O7.ClH/c1-8-9-5-4-6-12(25)13(9)17(26)14-10(8)7-11-16(24(2)3)18(27)15(21(23)30)20(29)22(11,31)19(14)28;/h4-6,11,16,25-26,29,31H,7H2,1-3H3,(H2,23,30);1H/t11-,16-,22-;/m0./s1
• Isómeros SMILES: CC1=C2C=CC=C(C2=C(C3=C1C[C@H]4[C@@H](C(=O)C(=C([C@]4(C3=O)O)O)C(=O)N)N(C)C)O)O.Cl
• Peso molecular: 462.88

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: Soluble in water to 25 mM
• Sensibilidad: moisture & air & light sensitive
• Punto de fusión (°C): 223℃
• Peso molecular: 462.900 g/mol
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 2
• Exact Mass: 462.119 Da
• Monoisotopic Mass: 462.119 Da
• Topological Polar Surface Area: 161.000 Ų
• Heavy Atom Count: 32
• Formal Charge: 0
• Complexity: 855.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 3
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

Referencias

1. Shuting Hu, Guangbao Zhang, Xiaoqiang Jia.  (2023)  Improvement of a highly sensitive and specific whole-cell biosensor by adding a positive feedback amplifier.  Synthetic and Systems Biotechnology,      [PMID:37090062] [10.1016/j.synbio.2023.03.007]

2. Zhang Guangbao, Hu Shuting, Jia Xiaoqiang.  (2021)  Highly Sensitive Whole-Cell Biosensor for Cadmium Detection Based on a Negative Feedback Circuit.  Frontiers in Bioengineering and Biotechnology,      [PMID:34926437] [10.3389/fbioe.2021.799781]