Azithromycin (CP-62993) - Moligand™, 10mM in DMSO , Bacterial 70S ribosome inhibitor, CAS No.83905-01-5, Bacterial 70S ribosome inhibitor

CAS: 83905-01-5 Cat. No.: A409086 Fórmula: C₃₈H₇₂N₂O₁₂ Peso molecular: 748.98 Número EC: 617-500-5

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

XZ-450 | (2R,​3S,​4R,​5R,​8R,​10R,​11R,​12S,​13S,​14R)​-13-​[(2,​6-​dideoxy-​3-​C-​methyl-​3-​O-​methyl-​α-​L-​ribo-​hexopyranosyl)​oxy]​-​2-​ethyl-​3,​4,​10-​trihydroxy-​3,​5,​6,​8,​10,​12,​14-​heptamethyl-​11-​[[3,​4,​6-​trideoxy-​3-​(dimethylamino)​-​β

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.
In vitro

Azithromycin reduces about 40% of IL-8 mRNA and protein expression in cystic fibrosis (CF) cells reaching the levels of non-CF cells. Azithromycin results in 50% and 70% reduction of NF-kappaB and AP-1 DNA binding, respectively, leading to levels of non-CF cells. Azithromycin significantly enhances the intensity of a co-stimulatory molecule, CD80, on DCs but not CD86 and CD40 in dendritic cells (DCs). Azithromycin significantly increases the production of IL-10 and Clarithromycin (CAM) significantly inhibits the production of IL-6 by DCs. Azithromycin increases IL-10 and CAM decreases IL-2 productions significantly, when naive T cells derived from spleen are co-cultured with DCs treated in advance with LPS and these macrolides. Azithromycin selectively inhibits fluid-phase endocytosis of horseradish peroxidase and lucifer yellow in J774 mouse macrophages. Azithromycin delays sequestration of receptor-bound transferrin and peroxidase-anti-peroxidase immune complexes into cell-surface endocytic pits and vesicles. Azithromycin down-regulates cell surface transferrin receptors, but not Fc gamma receptors, by causing a major delay in the accessibility of internalized transferrin receptors to the recycling route, without slowing down subsequent efflux, resulting in redistribution of the surface pool to an intracellular pool. Azithromycin inserts into the DOPC lipid bilayer, so as to decrease its cohesion and to facilitate the merging of DPPC into the DOPC fluid matrix.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:

Specifications

Sinónimos

XZ-450 | (2R,​3S,​4R,​5R,​8R,​10R,​11R,​12S,​13S,​14R)​-13-​[(2,​6-​dideoxy-​3-​C-​methyl-​3-​O-​methyl-​α-​L-​ribo-​hexopyranosyl)​oxy]​-​2-​ethyl-​3,​4,​10-​trihydroxy-​3,​5,​6,​8,​10,​12,​14-​heptamethyl-​11-​[[3,​4,​6-​trideoxy-​3-​(dimethylamino)​-​β

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Azithromycin (CP-62993, XZ-450) is an antibiotic by inhibiting protein synthesis, used for the treatment of bacterial infections.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

AGONIST, INHIBITOR

Mecanismo de acción

Bacterial 70S ribosome inhibitor

Propiedades del producto

ALogP

4

Nombres e identificadores

Isómeros SMILES

CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O

WGK Alemania

2

RTECS

RN6960000

Peso molecular

748.98

Reaxy-Rn

5387583

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=5387583&ln=

Objetivos asociados (humanos)

MLNR Tchem Motilin receptor (1 Activities)

Discover Target: MLNR

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 25 mg/mL (198.23 mM)