Bis(cyclohexanone)oxalyldihydrazone - ≥98% , CAS No.370-81-0

CAS: 370-81-0 Cat. No.: B110708 Peso molecular: 278.35 Beilstein Registry Number: 2388004 Número EC: 206-729-2

GRADE & PURITY ≥98%

Synonyms

UNII-5N16U7E0AO | DSRJIHMZAQEUJV-UHFFFAOYSA-N | AS-75478 | Bis(cyclohexanone) Oxalyldihydrazone | Cuprizone | Cupferazone | Oxalic acid bis(cyclohexylidenehydrazide)

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Descripción general

Cuprizone (Bis(cyclohexanone)oxaldihydrazone) is a physically unstable compound and is a well-known neurotoxic agent
A stain used in the quantitative spectroscopic determination of copper.

Specifications

Sinónimos

UNII-5N16U7E0AO | DSRJIHMZAQEUJV-UHFFFAOYSA-N | AS-75478 | Bis(cyclohexanone) Oxalyldihydrazone | Cuprizone | Cupferazone | Oxalic acid bis(cyclohexylidenehydrazide)

Especificaciones y pureza

≥98%

Mecanismos bioquímicos y fisiológicos

Bis(cyclohexanone)oxaldihydrazone used in the quantitative spectroscopic determination of copper as well as for the experimental study of mitochondrial metabolism.

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C, Argon charged

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥98%

Nombres e identificadores

• Pubchem Sid: 504751860
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504751860
• Sonrisas canónicas: C1CCC(=NNC(=O)C(=O)NN=C2CCCCC2)CC1
• IUPAC Name: N,N'-bis(cyclohexylideneamino)oxamide
• InChIKey: DSRJIHMZAQEUJV-UHFFFAOYSA-N
• INCHI: 1S/C14H22N4O2/c19-13(17-15-11-7-3-1-4-8-11)14(20)18-16-12-9-5-2-6-10-12/h1-10H2,(H,17,19)(H,18,20)
• Isómeros SMILES: C1CCC(=NNC(=O)C(=O)NN=C2CCCCC2)CC1
• WGK Alemania: 3
• RTECS: RO2520000
• Peso molecular: 278.35
• Beilstein: 2388004
• Reaxy-Rn: 2388004
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2388004&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives
• Direct Parent: Alpha amino acids and derivatives
• Alternative Parents: Semioxamazones Organopnictogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic homomonocyclic compounds
• Substituents: Alpha-amino acid or derivatives - Semioxamazone - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Carbonyl group - Aliphatic homomonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as alpha amino acids and derivatives. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon), or a derivative thereof.
• External Descriptors: a small molecule

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Solubilidad: Soluble in alcohol. Insoluble in water.
• Sensibilidad: Moisture sensitive
• Punto de fusión (°C): 213°C
• Peso molecular: 278.350 g/mol
• XLogP3: 1.600
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 278.174 Da
• Monoisotopic Mass: 278.174 Da
• Topological Polar Surface Area: 82.900 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 373.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Ziyang He, Qiang Huang, Liucheng Mao, Hongye Huang, Meiying Liu, Junyu Chen, Fengjie Deng, Naigen Zhou, Xiaoyong Zhang, Yen Wei.  (2020)  Direct surface modification of nanodiamonds with ionic copolymers for fast adsorptive removal of copper ions with high efficiency.  Colloid and Interface Science Communications,      [PMID:] [10.1016/j.colcom.2020.100278]

2. Yan Liu, Hongye Huang, Defu Gan, Linru Guo, Meiying Liu, Junyu Chen, Fengjie Deng, Naigen Zhou, Xiaoyong Zhang, Yen Wei.  (2018)  A facile strategy for preparation of magnetic graphene oxide composites and their potential for environmental adsorption.  CERAMICS INTERNATIONAL,      [PMID:] [10.1016/j.ceramint.2018.07.081]

3. Zhanying Li, Lin Shao, Zehai Ruan, Wenbin Hu, Lingbin Lu, Yongjun Chen.  (2018)  Converting untreated waste office paper and chitosan into aerogel adsorbent for the removal of heavy metal ions.  CARBOHYDRATE POLYMERS,      [PMID:29773376] [10.1016/j.carbpol.2018.04.003]

4. Qiang Huang, Jiao Zhao, Meiying Liu, Junyu Chen, Xiaoli Zhu, Ting Wu, Jianwen Tian, Yuanqing Wen, Xiaoyong Zhang, Yen Wei.  (2017)  Preparation of polyethylene polyamine@tannic acid encapsulated MgAl-layered double hydroxide for the efficient removal of copper (II) ions from aqueous solution.  Journal of the Taiwan Institute of Chemical Engineers,      [PMID:] [10.1016/j.jtice.2017.10.019]

5. Qiang Huang, Meiying Liu, Jiao Zhao, Junyu Chen, Guangjian Zeng, Hongye Huang, Jianwen Tian, Yuanqing Wen, Xiaoyong Zhang, Yen Wei.  (2017)  Facile preparation of polyethylenimine-tannins coated SiO2 hybrid materials for Cu2+ removal.  APPLIED SURFACE SCIENCE,      [PMID:] [10.1016/j.apsusc.2017.08.233]

6. Huang Qiang, Liu Meiying, Guo Ren, Mao Liucheng, Wan Qing, Zeng Guangjian, Huang Hongye, Deng Fengjie, Zhang Xiaoyong, Wei Yen.  (2016)  Facile synthesis and characterization of poly(levodopa)-modified silica nanocomposites via self-polymerization of levodopa and their adsorption behavior toward Cu2+.  JOURNAL OF MATERIALS SCIENCE,  51  (21): (9625-9637).  [PMID:] [10.1007/s10853-016-0178-z]

7. Ang Li, Runjun Lin, Chong Lin, Bianyang He, Tingting Zheng, Lingbin Lu, Yang Cao.  (2016)  An environment-friendly and multi-functional absorbent from chitosan for organic pollutants and heavy metal ion.  CARBOHYDRATE POLYMERS,      [PMID:27185140] [10.1016/j.carbpol.2016.04.070]

8. Xiaoliang Zhang, Xiaohong Chen, Xiaofang Shi, Xiaochun Li, Hua-Zhong Yu.  (2024)  Microscale quantitation of heavy metals by back-scattering interferometry in conjunction with photothermal effect using a single laser beam.  TALANTA,      [PMID:39721133] [10.1016/j.talanta.2024.127390]

9. Meiting Li, Zhuoyin Liu, Dan Peng, Yadong Liu, Lili Cheng, Baizhu Chen, Jie Liu.  (2025)  Multifunctional porous organic polymer-based hybrid nanoparticles for sonodynamically enhanced cuproptosis and synergistic tumor therapy.  Acta Biomaterialia,      [PMID:39993518] [10.1016/j.actbio.2025.02.045]

10. Fang Li, Nuotong Shen, Qingcheng Li, Chen Yang, Limin Zhang, Mingjin Wang.  (2024)  Multiplexed microfluidic chip based flow injection analysis system for simultaneous determination of Fe(III), Mn(II) and Cu(II).  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.112346]

11. Yaojun Ju, Yichen Yan, Xinhui Wang, Shan Li, Jialei Wang, Zixiao Wang, Yuling Dong, Junping Wang.  (2025)  Acer truncatum Bunge seeds oil ameliorated cuprizone induced cognitive decline and brain white matter impairment by improving sphingomyelin metabolism and neuroinflammation via activation of TREM2 signaling pathway.  Food & Function,      [PMID:41284332] [10.1039/D5FO03220B]

12. Fei Chen, Sisi Wu, Jian Kuang, Sijia Xiang, Shenghu Wang, Siming Yuan, Kaiming Cao, Lu Yu, Wenming Yang, Liqin Tang, Yangzhong Liu.  (2026)  Rosmarinic Acid Is an hCtr1 Inhibitor that Interferes with Copper Transport Activity.  INORGANIC CHEMISTRY,      [PMID:41494012] [10.1021/acs.inorgchem.5c04906]