Camptothecin-20(S)-O-propionate - ≥99% , DNA topoisomerase I inhibitor, CAS No.194414-69-2, DNA topoisomerase I inhibitor

CAS: 194414-69-2 Cat. No.: C646911 Peso molecular: 404.42 PubChem CID: 9887472

GRADE & PURITY ≥99%

Synonyms

CZ48 | CZ-48 | UNII-4S145C552U | 4S145C552U | CZ 48 | SF 6A | 1H-PYRANO(3',4':6,7)INDOLIZINO(1,2-B)QUINOLINE-3,14(4H,12H)-DIONE, 4-ETHYL-4-(1-OXOPROPOXY)-, (4S)- | MS-26907 | AKOS040748207 | Camptothecin-20-O-propionate | HY-114668 | (S)-4-ethyl-3,14-diox

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor .

In Vivo

Camptothecin-20(S)-O-propionate (CZ48, gavage, 100 to 2000 mg/kg/day) exhibits anti-tumor activity in CLO-breast carcinoma (100 mg/kg) and PC3-prostate carcinoma (1000 mg/kg) models in mice. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: A tumor xenograft growing in a nude mouse (size, ∼1 cm 3 ). Dosage: 100-1000 mg/kg/day. Administration: Oral gavage, for 2, 4 and 6 days, respectively. Result: Exhibited anti-tumor effect.

Form:Solid

Specifications

Sinónimos

CZ48 | CZ-48 | UNII-4S145C552U | 4S145C552U | CZ 48 | SF 6A | 1H-PYRANO(3', 4':6, 7)INDOLIZINO(1, 2-B)QUINOLINE-3, 14(4H, 12H)-DIONE, 4-ETHYL-4-(1-OXOPROPOXY)-, (4S)- | MS-26907 | AKOS040748207 | Camptothecin-20-O-propionate | HY-114668 | (S)-4-ethyl-3, 14-diox

Especificaciones y pureza

≥99%

Mecanismos bioquímicos y fisiológicos

Camptothecin-20(S)-O-propionate (CZ48), the C20-propionate ester of CPT, is a highly effective anticancer agent. Camptothecin-20(S)-O-propionate (CZ48) is a topoisomerase-Ι inhibitor.

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Tipo de acción

INHIBITOR

Mecanismo de acción

DNA topoisomerase I inhibitor

Pureza

≥99%

Propiedades del producto

• ALogP: 2

Nombres e identificadores

• Sonrisas canónicas: CCC(=O)OC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)CC
• IUPAC Name: [(19S)-19-ethyl-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaen-19-yl] propanoate
• InChIKey: YCNIQYLWIPCLNY-QHCPKHFHSA-N
• INCHI: 1S/C23H20N2O5/c1-3-19(26)30-23(4-2)16-10-18-20-14(9-13-7-5-6-8-17(13)24-20)11-25(18)21(27)15(16)12-29-22(23)28/h5-10H,3-4,11-12H2,1-2H3/t23-/m0/s1
• Isómeros SMILES: CCC(=O)O[C@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)CC
• CAS alternativo: 194414-69-2
• PubChem CID: 9887472
• Peso molecular: 404.42

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Alkaloids and derivatives
    • Clase Camptothecins

• Kingdom: Organic compounds
• Superclass: Alkaloids and derivatives
• Clase: Camptothecins
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Camptothecins
• Alternative Parents: Quinolines and derivatives Pyranopyridines Pyridinones Dicarboxylic acids and derivatives Benzenoids Heteroaromatic compounds Lactones Lactams Carboxylic acid esters Oxacyclic compounds Azacyclic compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Camptothecin - Pyranopyridine - Quinoline - Pyridinone - Dicarboxylic acid or derivatives - Pyridine - Benzenoid - Heteroaromatic compound - Lactone - Lactam - Carboxylic acid ester - Organoheterocyclic compound - Carboxylic acid derivative - Azacycle - Oxacycle - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic nitrogen compound - Organic oxygen compound - Organooxygen compound - Organonitrogen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as camptothecins. These are heterocyclic compounds comprising a planar pentacyclic ring structure, that includes a pyrrolo[3,4-beta]-quinoline moiety (rings A, B and C), conjugated pyridone moiety (ring D) and one chiral center at position 20 within the alpha-hydroxy lactone ring with (S) configuration (the E-ring).
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Mecanismos de acción

Propiedades químicas y físicas

• Solubilidad: DMSO : 9.09 mg/mL (22.48 mM; Need ultrasonic)
• Peso molecular: 404.400 g/mol
• XLogP3: 2.000
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 4
• Exact Mass: 404.137 Da
• Monoisotopic Mass: 404.137 Da
• Topological Polar Surface Area: 85.800 Ų
• Heavy Atom Count: 30
• Formal Charge: 0
• Complexity: 862.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1