Candesartan (CV-11974) - Moligand™, 10mM in DMSO , Antagonist of AT 1 receptor, CAS No.139481-59-7, Antagonist of AT 1 receptor

CAS: 139481-59-7 Cat. No.: C408360 Peso molecular: 440.45 Número EC: 604-138-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Candesartan (CV-11974) Candesartan (CV-11974) is an angiotensin II receptor antagonist with IC50 of 0.26 nM.
In vitro

Candesartan binds with high specificity to the angiotensin II AT1 receptors in CHO-AT1 cells with K₋₁ of 0.001 min⁻¹. Candesartan does not affect cell viability or proliferation but increases the expression of VEGF and interleukin-8 in the cultured medium of KU-19-19 cells. Candesartan (0.1 nM) could reduce the maximal contractile response to angiostensin II by approximately 50%.

In vivo

Candesartan (10 mg/kg) inhibits the growth of engrafted tumors and reduces the microvessel density and VEGF expression in a mouse KU-19-19 xenograft model Candesartan (0.5 mg/kg) decreases blood pressure and inhibits AT1 binding in the subfornical organ (SFO), paraventricular nucleus of the hypothalamus (PVN), nucleus of the solitary tract (NTS) and area postrema (AP) in WKY rats. Candesartan (0.3 mg/kg) pretreatment decreases the infarct area by 31% in adult spontaneously hypertensive rats, reduces the CBF decrease at the peripheral area of ischemia and the cortical volume of severe ischemic lesion.
Cell Data

cell lines：NCI-H2228 cells

Concentrations：10 μM

Incubation Time：48 hours

Powder Purity:≥99%

Specifications

Sinónimos

1H-Benzimidazole-7-carboxylic acid, 2-ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1, 1'-biphenyl]-4-yl]methyl]-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Candesartan (CV-11974) is an angiotensin II receptor antagonist with IC50 of 0.26 nM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

ANTAGONIST

Mecanismo de acción

Antagonist of AT 1 receptor

Propiedades del producto

• ALogP: 4.1

Nombres e identificadores

• Isómeros SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)O
• CAS alternativo: 139481-59-7
• Número NSC: 759858
• Términos de entrada MeSH: 2-ethoxy-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-benzimidazole-7-carboxylic acid;2-ethoxy-7-carboxy-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylbenzimidazole;candesartan;CV 11974;CV-11974;CV11974
• Peso molecular: 440.45
• Reaxy-Rn: 9232176
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9232176&ln=

Objetivos asociados (humanos)

AGTR1 Tclin Type-1 angiotensin II receptor (4 Activities)

Discover Target: AGTR1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Punto de congelación (°C): 183-185°C

Referencias

1. Yanan Guo, Shuang Cao, Bin Geng, Juanjuan Ma, Bo Yao.  (2024)  Determination of sacubitril and seven sartan drugs in serum samples by online solid phase extraction-liquid chromatography-tandem mass spectrometry.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:39603194] [10.1016/j.jpba.2024.116580]

2. Liang Song, Weiwei Zheng, Shuqin Wang, Zihe Zhai, Shifen Li, Jie Ding, Liyin Shen, Jinyue Zhang, Yang Zhu, Changyou Gao.  (2025)  ROS-responsive core–shell microgels for phase-specific treatment of myocardial infarction via programmed drug delivery.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.160295]

3. Dafa Yi, Jiazong Ye, Zebei Lu, Leilei Lu, Tengfei Qi, Tong Luo, Xiuyun Peng, Abdullah Al Mamun, Quan Zhou, Daqing Chen, Shuanghu Wang.  (2025)  Effects of anti-hypertensive drugs on the metabolism of mobocertinib in rats both in vitro and in vivo.  DRUG METABOLISM AND DISPOSITION,      [PMID:40482432] [10.1016/j.dmd.2025.100094]

4. Zhenyu Wu, Xufang Huo, Yubing Huang, Taowu Gong, Pengcheng Zhao, Yuhang Zhu, Qingfan Zeng.  (2026)  AngII promotes hippocampal neuron ferroptosis via inhibiting the PPARγ/ACSL3 axis leading to hypertension-related cognitive impairment.  EXPERIMENTAL NEUROLOGY,      [PMID:] [10.1016/j.expneurol.2026.115755]