In this article, “tetrazole” refers to the five-membered nitrogen heterocycle composed of one carbon and four nitrogens. For readability, we use tetrazole throughout. The importance of tetrazoles is not simply “having many nitrogens,” but rather that this small ring simultaneously offers ...
Strained alkenes leverage strain relief as a motivating factor, enabling their engagement in click reactions. Trans-cycloalkenes, typically cyclooctenes, and other strained alkenes like oxanorbornadiene, participate in click reactions with various counterparts, including azides, tetrazines, and ...
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