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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 24 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Captopril (SQ 14225) is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM.
In vitro
In vivo
Cell Data
cell lines:
Concentrations:
Incubation Time:
Powder Purity:≥99%
| ALogP | 0.3 |
|---|
| Isómeros SMILES | C[C@H](CS)C(=O)N1CCC[C@H]1C(=O)O |
|---|---|
| WGK Alemania | 3 |
| RTECS | UY0550000 |
| Peso molecular | 217.29 |
| Beilstein | 477887 |
| Reaxy-Rn | 3651421 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=3651421&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Activity Type | Activity Value -log(M) | Mechanism of Action | Activity Reference | Publications (PubMed IDs) |
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| Solubilidad | Solubility (25°C) In vitro DMSO: 30 mg/mL (197.17 mM); Ethanol: -1 mg/mL |
|---|---|
| Rotación específica [α] | -127.5° |
| Punto de fusión (°C) | 106°C |
| 1. Qinglin Wang, Hao Yuan, Xinyue Pan, Yiling Yang, Xiaosong Ma, Yahui Guo. (2023) Synthesis of silver nanoclusters using a double-stranded DNA template and its application for captopril detection. JOURNAL OF FOOD COMPOSITION AND ANALYSIS, [PMID:] [10.1016/j.jfca.2023.105825] |
| 2. Yanan Guan, Yueyue Zu, Pengyi Ma, Shutao Li, Qi Ma, Jinping Song, Yong Guo. (2023) Cascade Fluorescent Determination of Mercury (II) and Captopril Using Tungsten-Nitrogen Doped Carbon Dots. ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2023.2180802] |
| 3. Jing Zhu, Lei Hu, Xiangying Meng, Feng Li, Wenjuan Wang, Guiyang Shi, Zhongxia Wang. (2023) Synergism of Photo-Induced Electron Transfer and Aggregation-Induced Quenching Mechanisms for Highly Sensitive Detection of Silver Ion and Captopril. MOLECULES, 28 (9): (3650). [PMID:37175061] [10.3390/molecules28093650] |
| 4. Xuwen Gao, Xiancheng Liu, Ying Zeng, Qingqing Zhang, Bin Zhang, Guizheng Zou. (2022) Spectrum-Resolved Electrochemiluminescence to Multiplex the Immunoassay and DNA Probe Assay. ANALYTICAL CHEMISTRY, [PMID:36334096] [10.1021/acs.analchem.2c03579] |
| 5. Kun Liu, Xiaohan Zhang, Xiongfeng Zhou, Xinming Huo, Xiaohao Wang, Kostya (Ken) Ostrikov. (2022) Experimental investigation of an atmospheric pressure plasma jet as an ion source for on-site mass-spectrometry analysis of nonvolatile solid samples: the integration effect of thermal desorption and ionization. JOURNAL OF PHYSICS D-APPLIED PHYSICS, 55 (48): (485202). [PMID:] [10.1088/1361-6463/ac968a] |
| 6. Wang Yiran, Shi Jihua, Dai Dapeng, Cai Jianping, Wang Shuanghu, Hong Yun, Zhou Shan, Zhao Fangling, Zhou Quan, Geng Peiwu, Zhou Yunfang, Xu Xue, Luo Qingfeng. (2022) Evaluation of commonly used cardiovascular drugs in inhibiting vonoprazan metabolism in vitro and in vivo. Frontiers in Pharmacology, [PMID:36052128] [10.3389/fphar.2022.909168] |
| 7. Lixia Han, Ting Liu, Di Cui, Jiaqi Yi, Wei Jiang, Xiaoshuang Li, Na Niu, Ligang Chen. (2022) Quantitative detection of captopril in urine by smartphone-assisted ratiometric fluorescence sensing platform. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:35780761] [10.1016/j.saa.2022.121562] |
| 8. Shuangtian Dong, Dongyang Wang, Xuwen Gao, Li Fu, Jingna Jia, Yuqi Xu, Bin Zhang, Guizheng Zou. (2022) Glow and Flash Adjustable Chemiluminescence with Tunable Waveband from the Same CuInS2@ZnS Nanocrystal Luminophore. ANALYTICAL CHEMISTRY, [PMID:35486816] [10.1021/acs.analchem.2c01083] |
| 9. Cheng-Yuan Dong, Sheng Hong, Di-Wei Zheng, Qian-Xiao Huang, Fu-Sheng Liu, Zhen-Lin Zhong, Xian-Zheng Zhang. (2020) Multifunctionalized Gold Sub-Nanometer Particles for Sensitizing Radiotherapy against Glioblastoma. Small, 17 (5): (2006582). [PMID:33382206] [10.1002/smll.202006582] |
| 10. Zhong-Xia Wang, Xing Jin, Wen-Juan Wang, Fen-Ying Kong, Jing Zhu, Heng-Ye Li, Yu-Jie Ding, Wei Wang. (2020) Green synthesis of a deep-ultraviolet carbonized nanoprobe for ratiometric fluorescent detection of feroxacin and enrofloxacin in food and serum samples. ANALYST, 146 (3): (874-881). [PMID:33241796] [10.1039/D0AN02114H] |
| 11. Yang Xu, Jin Li, Jian Zhou, Yufeng Liu, Zhuojun Wei, Hui Zhang. (2020) Layered double hydroxides supported atomically precise Aun nanoclusters for air oxidation of benzyl alcohol: Effects of size and active site structure. JOURNAL OF CATALYSIS, [PMID:] [10.1016/j.jcat.2020.06.017] |
| 12. Tian Ruochen, Suo Hao, Zhang Shuting, Sun Baoshan. (2020) Separation of a family of antioxidants flavan-3-ol thio-conjugates from procyanidins by high-speed counter-current chromatography. EUROPEAN FOOD RESEARCH AND TECHNOLOGY, 246 (5): (1017-1029). [PMID:] [10.1007/s00217-020-03465-4] |
| 13. Zhang Pu, Wang Li, Zeng Jing, Tan Juan, Long Yunfei, Wang Yi. (2020) Colorimetric captopril assay based on oxidative etching-directed morphology control of silver nanoprisms. MICROCHIMICA ACTA, 187 (2): (1-8). [PMID:31915936] [10.1007/s00604-019-4071-8] |
| 14. Shi Yi, Peng Jun, Meng Xiaoyan, Huang Tao, Zhang Jingyi, He Hua. (2018) Turn-on fluorescent detection of captopril in urine samples based on hydrophilic hydroxypropyl β-cyclodextrin polymer. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 410 (28): (7373-7384). [PMID:30191274] [10.1007/s00216-018-1343-9] |
| 15. Wang Zhong-Xia, Gao Yuan-Fei, Yu Xian-He, Kong Fen-Ying, Lv Wei-Xin, Wang Wei. (2018) Photoluminescent coral-like carbon-branched polymers as nanoprobe for fluorometric determination of captopril. MICROCHIMICA ACTA, 185 (9): (1-9). [PMID:30128634] [10.1007/s00604-018-2961-9] |
| 16. YingHui Zhang, Bing Wang, Feng Guo, ZhiZhen Li, GuiJun Qin. (2018) Involvement of the TGFβ1- ILK-Akt signaling pathway in the effects of hesperidin in type 2 diabetic nephropathy. BIOMEDICINE & PHARMACOTHERAPY, [PMID:29909344] [10.1016/j.biopha.2018.06.036] |
| 17. Li Zhang, Qiao Huang, Wan-Ying Gong, Wen-Jing Wang, Chun-Ting Yang, Wei-Tao Zhang, Jun Sheng, Jing Xie, Yang Tian. (2025) Structure-activity relationship analysis of the ACE inhibitory activity of three walnut protein hydrolysates and elucidation of the ACE inhibitory mechanism of its derived peptides. LWT-FOOD SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.lwt.2025.118131] |
| 18. Liu Changtong, Guo Rui, Zhou Yue, Zhu Miao, Shao Li, Wang Yingchao, Zhao Lu. (2025) Salvianolic acid B and Senkyunolide I synergistically alleviate cardiac hypertrophy and regulate MAP3K1 signaling. Chinese Medicine, 20 (1): (1-20). [PMID:41015772] [10.1186/s13020-025-01189-9] |
| 19. Xu Tao, Ji Haifeng, Xu Lin, Cheng Shengjun, Liu Xianda, Li Yupei, Zhong Rui, Zhao Weifeng, Kizhakkedathu Jayachandran N., Zhao Changsheng. (2023) Self-anticoagulant sponge for whole blood auto-transfusion and its mechanism of coagulation factor inactivation. Nature Communications, 14 (1): (1-20). [PMID:37573353] [10.1038/s41467-023-40646-7] |
| 20. Haiyan Cao, Mingjie Tang, Xin Wang, Wenbing Shi. (2020) Facile and rapid synthesis of emission color-tunable molybdenum oxide quantum dots as a versatile probe for fluorescence imaging and environmental monitoring. ANALYST, 145 (19): (6270-6276). [PMID:32936129] [10.1039/D0AN01510E] |
| 21. Hanyu Yang, Hui Chen, Ling Jiang, Jie Hu, Xiupei Yang, Qian Zhang. (2025) Ratiometric fluorescence detection of captopril using folic acid-assisted β-cyclodextrin‑copper nanoclusters with smartphone-based visualization. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2025.115164] |
| 22. Xin Huang, Hong Shen, Zirui Li, Tingting Fu, Xin Wei, Sainan Qiu. (2025) Isochlorogenic Acid A Attenuated Periodontitis by Inhibiting Inflammation via ACE/PGK1/STAT1 Signaling. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:40368646] [10.1021/acs.jafc.4c13299] |
| 23. Yuqi Zhang, Karen Ching, Lanlan Zhang, Lin Zhu, Siu Ling Yip, Xuan Lu, Zhongyu Liu, ZongWei Cai, Man Ting Au, Chunyi Wen. (2025) Endothelial Dysfunction Contributes to Chondrocyte Senescence Associated With Insulin‐Like Growth Factor‐Binding Protein‐6 in a Spontaneously Hypertensive Rat Model. Journal of the American Heart Association, [PMID:41404752] [10.1161/JAHA.124.042132] |
| 24. Jingwei Tian, Mingsheng Zhu, Zhenyu Guan, Jianxin Liu, Yuanke Li, Qiqi Liu, Yingqi Miao, Jin Wu, Che Zhou, Xiangyang Wang, Jie Zhuang, Xinglu Huang. (2026) Redefining Tumor Vascular Permeability through Deep Learning-Guided Microneedle Delivery. ACS Nano, [PMID:41660810] [10.1021/acsnano.5c16558] |
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