GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

1,2,4-Thiadiazolidine-3,5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

CCG 50014 CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.
In vitro

CCG-50014 is highly potent at inhibiting RGS4 and it fully inhibits several other RGS proteins, including RGS8, -16, and -19, but does not have activity on RGS7. Furthermore, CCG-50014 has no activity on a mutated form of RGS4 that lacks cysteine residues in the RGS homology domain (RGS4Cys−). CCG-50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG-50014 is able to inhibit the RGS4−Gαo protein−protein interaction in a living cell. CCG-50014 represents the first of a class of small molecule RGS inhibitors that function in a cellular environment. ^{[1] [2]}

In vivo

Cell Data

cell lines：human granulosa cell lines (GC1a, HGL5, COV434)

Concentrations：

Incubation Time：

Powder Purity:≥97%

Specifications

Sinónimos

1, 2, 4-Thiadiazolidine-3, 5-dione, 4-[(4-fluorophenyl)methyl]-2-(4-methylphenyl)-

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

CCG 50014 is a potent and selective inhibitor of RGS4 with IC50 of 30 nM.

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Inhibitor of regulator of G-protein signaling 19;Inhibitor of regulator of G-protein signaling 4;Inhibitor of regulator of G-protein signaling 8

Nombres e identificadores

• Isómeros SMILES: CC1=CC=C(C=C1)N2C(=O)N(C(=O)S2)CC3=CC=C(C=C3)F
• WGK Alemania: 3
• Peso molecular: 316.35
• Reaxy-Rn: 22320416
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22320416&ln=

Objetivos asociados (humanos)

RGS19 Tchem Regulator of G-protein signaling 19 (1 Activities)

Discover Target: RGS19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS8 Tchem Regulator of G-protein signaling 8 (1 Activities)

Discover Target: RGS8

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

RGS4 Tchem Regulator of G-protein signaling 4 (3 Activities)

Discover Target: RGS4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)