Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 24 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Clarithromycin (A-56268) is a macrolide antibiotic and aCYP3A4inhibitor, used to treat a number of bacterial infections.
In vitro
Clarithromycin suppresses this production in a dose-dependent manner in both monocytes and THP-1 cells. Clarithromycin regulates three other promoters that have either the NF-kappa B or the AP-1 binding sequences: two synthetic (pAP-1-Luc and pNF-kappa B-Luc) and one naturally occurring (ELAM-Luc). Clarithromycin suppresses NF-kappaB activation induced by TNF-alpha in U-937 and Jurkat cells in a concentration-related manner. Clarithromycin inhibits NF-kappaB activation induced by TNF-alpha in U-937, Jurkat, and A549 cells and PBMC and by SEA in PBMC. Clarithromycin prevents NF-kappaB-dependent reporter gene expression in U-937 cells. Clarithromycin results in a significant suppression of production of each cytokine in 71% and a significant increase in 29% of the human monocytes. Clarithromycin inhibits tumor necrosis factor (TNF)-alpha-induced IL-8 gene expression in a dose- and incubation time-dependent manner. Clarithromycin represses AP-1 binding in TNF-alpha-treated BET-1A cells. Clarithromycin represses IL-8 gene transcription mainly via the AP-1 binding site in human bronchial epithelial cells. Clarithromycin suppresses IL-1 beta gene expression in human nasal epithelial cells stimulated by H. influenzae endotoxin (HIE). Clarithromycin suppresses intercellular adhesion molecule-1 gene expression in nasal fibroblasts stimulated by IL-1 beta. Clarithromycin reduces DNA-binding activity of NF-kappa B in both human nasal epithelial cells and fibroblasts stimulated by HIE or IL-1 beta, respectively.
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isómeros SMILES | CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O |
|---|---|
| WGK Alemania | 3 |
| RTECS | KF4997000 |
| CAS alternativo | 81103-11-9,116836-41-0 |
| Número NSC | 758704 |
| Términos de entrada MeSH | 6-O-Methylerythromycin;A 56268;A-56268;A56268;Biaxin;Clarithromycin;TE 031;TE-031;TE031 |
| Peso molecular | 747.95 |
| Reaxy-Rn | 24709380 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24709380&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
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View spec sheet →| Solubilidad | Solubility (25°C) In vitro DMSO: 57 mg/mL (200.46 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Rotación específica [α] | -92°C |
| Punto de fusión (°C) | 225°C |
| 1. Xiaoyu Zhang, Peiran Meng, Wei Wang, Xiwen Li, Zuan Yang, Shaokai Du, Yue Sun. (2023) Simultaneous Electrochemical Determination of Erythromycin and Hemoglobin by Flexible Carbon Cloth Modified with ZnO Nanorod Arrays and Au Nanoparticles by Differential Pulse Voltammetry (DPV). ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2023.2292664] |
| 2. Qin Tang, Zhengcai Ma, Xiang Tang, Yan Liu, Huimin Wu, Yu Peng, Baihua Jiao, Rui Wang, Xiaoli Ye, Hang Ma, Xuegang Li. (2023) Coptisine inhibits Helicobacter pylori and reduces the expression of CagA to alleviate host inflammation in vitro and in vivo. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:37164257] [10.1016/j.jep.2023.116618] |
| 3. Ruoyu Deng, Dongxu Yang, Mengli Chen, Qiang He, Qingjuan He, Yi Chen. (2023) The enhancing energy efficiency of sulfadiazine degradation using a DBD-contact plasma treatment process. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.142491] |
| 4. Chong Yu, Chi Li, Ying Zhang, Xiang Du, Jing-Han Wang, Zhan-You Chi, Qian Zhang. (2023) Effects of environment-relevant concentrations of antibiotics on seawater Chlorella sp. biofilm in artificial mariculture effluent. Algal Research-Biomass Biofuels and Bioproducts, [PMID:] [10.1016/j.algal.2023.103008] |
| 5. Yu Wang, Yunxiang He, Qin Wang, Xiaoling Wang, Blaise L. Tardy, Joseph J. Richardson, Orlando J. Rojas, Junling Guo. (2022) Microporous membranes for ultrafast and energy-efficient removal of antibiotics through polyphenol-mediated nanointerfaces. Matter, [PMID:] [10.1016/j.matt.2022.09.021] |
| 6. Ling Li, Yaoyao Du, Yang Wang, Ning He, Bing Wang, Tong Zhang. (2022) Atractylone Alleviates Ethanol-Induced Gastric Ulcer in Rat with Altered Gut Microbiota and Metabolites. Journal of Inflammation Research, [PMID:35996682] [10.2147/JIR.S372389] |
| 7. Shuting Zeng, Jing Sun, Ziwei Chen, Qiuxiang Xu, Wei Wei, Dongbo Wang, Bing-Jie Ni. (2021) The impact and fate of clarithromycin in anaerobic digestion of waste activated sludge for biogas production. ENVIRONMENTAL RESEARCH, [PMID:33545126] [10.1016/j.envres.2021.110792] |
| 8. Xueqing Guo, Yang Liu, Wenjuan Dong, Qin Hu, Yong Li, Shaomin Shuang, Chuan Dong, Lishuai Cai, Xiaojuan Gong. (2021) Azithromycin detection in cells and tablets by N,S co-doped carbon quantum dots. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:33561684] [10.1016/j.saa.2021.119506] |
| 9. Zhou Chen, Yanzeng Li, Yanyan Peng, Chengsong Ye, Shenghua Zhang. (2020) Effects of antibiotics on hydrolase activity and structure of microbial community during aerobic co-composting of food waste with sewage sludge. BIORESOURCE TECHNOLOGY, [PMID:33310386] [10.1016/j.biortech.2020.124506] |
| 10. Yuanna Shen, Yiqing Zou, Xiaonan Chen, Pengyu Li, Yiqin Rao, Xuan Yang, Yingying Sun, Haiyan Hu. (2020) Antibacterial self-assembled nanodrugs composed of berberine derivatives and rhamnolipids against Helicobacter pylori. JOURNAL OF CONTROLLED RELEASE, [PMID:32946873] [10.1016/j.jconrel.2020.09.025] |
| 11. Ziming Zhao, Yanzhu Guo, Tao Zhang, Jiliang Ma, Haiming Li, Jinghui Zhou, Zhiwei Wang, Runcang Sun. (2020) Preparation of carbon dots from waste cellulose diacetate as a sensor for tetracycline detection and fluorescence ink. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:32891644] [10.1016/j.ijbiomac.2020.08.243] |
| 12. Yunlei Zhou, Fei Li, Hanwen Wu, Yan Chen, Huanshun Yin, Shiyun Ai, Jun Wang. (2019) Electrochemical aptasensing strategy for kanamycin detection based on target-triggered single-strand DNA adsorption on MoS2 nanosheets and enzymatic signal amplification. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2019.126664] |
| 13. Pengyu Li, Xiaonan Chen, Yuanna Shen, Huatian Li, Yiqing Zou, Gang Yuan, Ping Hu, Haiyan Hu. (2019) Mucus penetration enhanced lipid polymer nanoparticles improve the eradication rate of Helicobacter pylori biofilm. JOURNAL OF CONTROLLED RELEASE, [PMID:30825476] [10.1016/j.jconrel.2019.02.039] |
| 14. Yaowei Zhu, Ruijie Tang, Jun Zhao, Changlong Jiang, Lingfei Li, Bianhua Liu. (2025) Design and application of metal-organic framework based chemo-fluorescent sensor for selective sensing of the full spectrum of tetracyclines in complex samples. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.160281] |
| 15. Wanjun Long, Huanhuan Lu, Yulong Han, Hengye Chen, Wei Lan, Yuanbin She, Haiyan Fu. (2025) Machine learning-assisted smartphone-based fluorescence visual sensing platform for ultrasensitive detection of chlortetracycline. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2025.137241] |
| 16. Yongze Liu, Mei Li, Genyuan Li, Lei He, Xiaofeng Ma, Zhaoxiang Zhang, Jun Zhang. (2025) Rapidly self-crosslinking sodium alginate hydrogel for infected wounds. JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, [PMID:39760654] [10.1080/09205063.2024.2438497] |
| 17. Linqian Hou, Qiulan Li, Jitao Li, Dezhi Yang, Yaling Yang. (2025) Cu,Fe,B/Cur-CDs with peroxidase- and ascorbic acid oxidase-like catalytic activity for dual-signal fluorescence sensing of metronidazole. FOOD CHEMISTRY, [PMID:40774207] [10.1016/j.foodchem.2025.145757] |
| 18. Jiahong Zheng, Xiudan Shi, Pengzhan Li, Zhiguo Zhao, Guangqiang Ding. (2025) Preparation of a Cs4PbBr6 NCs@PCDs ratiometric fluorescent probe and detection of amoxicillin. NEW JOURNAL OF CHEMISTRY, [PMID:] [10.1039/D5NJ02499D] |
| 19. Wenjuan Dong, Lu Wang, Rongrong Zhang, Chaochao Wen, Ren Su, Xiaojuan Gong, Wenting Liang. (2023) High luminescent N,S,P co-doped carbon dots for the fluorescence sensing of extreme acidity and folic acid. DALTON TRANSACTIONS, 52 (19): (6551-6558). [PMID:37185994] [10.1039/D3DT00560G] |
| 20. Jian Zhang, Zhijun Bao, Jingjing Qian, Haibo Zhou, Kui Zhang. (2022) Copper doped zinc sulfide quantum dots as ratiometric fluorescent probes for rapid and specific detection of tetracycline residues in milk. ANALYTICA CHIMICA ACTA, [PMID:35691678] [10.1016/j.aca.2022.339991] |
| 21. Wan-Feng Xu, Yun Wang, Hai Huang, Jia-Wei Wu, Yuan Che, Chu-Jie Ding, Quan Zhang, Wei-Ling Cao, Li-Juan Cao. (2022) Octreotide-based therapies effectively protect mice from acute and chronic gastritis. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:35487253] [10.1016/j.ejphar.2022.174976] |
| 22. Li Zhang, Huaizhong Xing, Wei Liu, Zihan Wang, Yumin Hao, Huiping Wang, Wenjuan Dong, Yang Liu, Shaomin Shuang, Chuan Dong, Xiaojuan Gong. (2021) 11-Mercaptoundecanoic Acid-Functionalized Carbon Dots As a Ratiometric Optical Probe for Doxorubicin Detection. ACS Applied Nano Materials, [PMID:] [10.1021/acsanm.1c03141] |
| 23. Pusheng Xu, Yi Li, Bihan Xu, Dan Cao, Xu Dong, Yanghui Xiang, Xiuzhi Jiang, Xin Yuan, Yuwei Qiu, Ying Zhang. (2025) Novel mutations in the marR gene (MAB_2648c) modify nitroxoline activity in Mycobacterium abscessus. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 69 (5): [PMID:40167421] [10.1128/aac.01744-24] |
| 24. Yukun Lin, Kunjing Liu, Jiahui Chen, Tingjie Li, Zijin Sun, Yifan Fan, Peng Zou, Yanting Liu, Chunyu Wang, Chongyang Ma, Xueqian Wang, Fang Lu, Fafeng Cheng, Changming Zhai. (2025) Pinellia ternata–Coptidis Rhizoma herb pair suppresses Helicobacter pylori colonization via NLRP3-mediated pyroptosis. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:41389884] [10.1016/j.jep.2025.121018] |
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