Clindamycin Phosphate - 10mM in Water , CAS No.24729-96-2

CAS: 24729-96-2 Cat. No.: C422848 Peso molecular: 504.96 Número EC: 246-433-0

GRADE & PURITY 10mM in Water

Synonyms

Clindamycin phosphate|24729-96-2|Cleocin phosphate|Clindamycin 2-phosphate|Clindets|Cleocin T|Clindagel|Clindesse|Evoclin|Clinda-Derm|Dalacin P|CLINDAMYCIN-2-PHOSPHATE|Clindamax|Clindamycin 2-dihydrogen phosphate|Dalacin T|Clindamycin injection|7(S)-Chlor

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Clindamycin Phosphate is a lincosamide antibiotic for Plasmodium falciparum with IC50 of 12 nM.

Clindamycin is a lincosamide antibiotic which is considered as a semisynthetic derivative of lincomycin. It is mainly used as an antimicrobial agent.

An antibiotic with anti-inflammatory properties.

Specifications

Sinónimos

Clindamycin phosphate | 24729-96-2 | Cleocin phosphate | Clindamycin 2-phosphate | Clindets | Cleocin T | Clindagel | Clindesse | Evoclin | Clinda-Derm | Dalacin P | CLINDAMYCIN-2-PHOSPHATE | Clindamax | Clindamycin 2-dihydrogen phosphate | Dalacin T | Clindamycin injection | 7(S)-Chlor

Especificaciones y pureza

10mM in Water

Mecanismos bioquímicos y fisiológicos

Clindamycin Phosphate (U-28508E) is an antibiotic with anti-inflammatory properties. The compound is a potent antibiotic against anaerobic and gram-positive bacteria. Studies show that Clindamycin associates with the 50S ribosomal subunit, which leads to

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Propiedades del producto

• ALogP: -1.2

Nombres e identificadores

• Sonrisas canónicas: CCCC1CC(N(C1)C)C(=O)NC(C2C(C(C(C(O2)SC)OP(=O)(O)O)O)O)C(C)Cl
• IUPAC Name: [(2R,3R,4S,5R,6R)-6-[(1S,2S)-2-chloro-1-[[(2S,4R)-1-methyl-4-propylpyrrolidine-2-carbonyl]amino]propyl]-4,5-dihydroxy-2-methylsulfanyloxan-3-yl] dihydrogen phosphate
• InChIKey: UFUVLHLTWXBHGZ-MGZQPHGTSA-N
• INCHI: 1S/C18H34ClN2O8PS/c1-5-6-10-7-11(21(3)8-10)17(24)20-12(9(2)19)15-13(22)14(23)16(18(28-15)31-4)29-30(25,26)27/h9-16,18,22-23H,5-8H2,1-4H3,(H,20,24)(H2,25,26,27)/t9-,10+,11-,12+,13+,14-,15+,16+,18+/m0/s1
• Isómeros SMILES: CCC[C@@H]1C[C@H](N(C1)C)C(=O)N[C@@H]([C@@H]2[C@@H]([C@@H]([C@H]([C@H](O2)SC)OP(=O)(O)O)O)O)[C@H](C)Cl
• WGK Alemania: 3
• RTECS: GF2625000
• Peso molecular: 504.96
• Reaxy-Rn: 42193760
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=42193760&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Clase Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Proline and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Clase: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Proline and derivatives
• Alternative Parents: Alpha amino acid amides Thioglycosides Pyrrolidinecarboxamides Monoalkyl phosphates Oxanes N-alkylpyrrolidines Monosaccharides Monothioacetals Trialkylamines Secondary carboxylic acid amides Secondary alcohols 1,2-diols Sulfenyl compounds Oxacyclic compounds Azacyclic compounds Hydrocarbon derivatives Carbonyl compounds Organic oxides Organochlorides Alkyl chlorides Organopnictogen compounds
• Molecular Framework: Aliphatic heteromonocyclic compounds
• Substituents: Proline or derivatives - Alpha-amino acid amide - Glycosyl compound - S-glycosyl compound - Pyrrolidine carboxylic acid or derivatives - Pyrrolidine-2-carboxamide - Monoalkyl phosphate - Monosaccharide - Organic phosphoric acid derivative - Oxane - Phosphoric acid ester - N-alkylpyrrolidine - Alkyl phosphate - Pyrrolidine - Monothioacetal - Tertiary aliphatic amine - Tertiary amine - Secondary carboxylic acid amide - Secondary alcohol - Carboxamide group - 1,2-diol - Azacycle - Organoheterocyclic compound - Oxacycle - Sulfenyl compound - Hydrocarbon derivative - Organonitrogen compound - Organochloride - Alcohol - Organohalogen compound - Organooxygen compound - Organosulfur compound - Organic oxygen compound - Carbonyl group - Amine - Alkyl chloride - Alkyl halide - Organic nitrogen compound - Organopnictogen compound - Organic oxide - Aliphatic heteromonocyclic compound
• Descripción: This compound belongs to the class of organic compounds known as proline and derivatives. These are compounds containing proline or a derivative thereof resulting from reaction of proline at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Objetivos asociados (humanos)

F2 Tclin Thrombin (11687 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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GABRA1 Tclin GABA receptor alpha-1 subunit (399 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

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HTR2B Tclin Serotonin 2b (5-HT2b) receptor (10323 Activities)

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TBXA2R Tclin Thromboxane A2 receptor (5717 Activities)

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PDE4A Tclin Phosphodiesterase 4A (1943 Activities)

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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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HRH3 Tclin Histamine H3 receptor (10389 Activities)

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KDR Tclin Vascular endothelial growth factor receptor 2 (20924 Activities)

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Homo sapiens (32628 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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Objetivos asociados (no humanos)

Hdac6 Histone deacetylase 6 (222 Activities)

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Bacteroides fragilis (1445 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Mecanismos de acción

Propiedades químicas y físicas

• Rotación específica [α]: 122° (C=1,H2O)
• Punto de fusión (°C): 114°C
• Peso molecular: 505.000 g/mol
• XLogP3: -1.200
• Hydrogen Bond Donor Count: 5
• Hydrogen Bond Acceptor Count: 10
• Rotatable Bond Count: 9
• Exact Mass: 504.146 Da
• Monoisotopic Mass: 504.146 Da
• Topological Polar Surface Area: 174.000 Ų
• Heavy Atom Count: 31
• Formal Charge: 0
• Complexity: 658.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 9
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

Referencias

1. Hui Xu, Yingxiang Du, Zijie Feng, Xiaodong Sun, Jie Liu.  (2019)  Synthesis of a chiral ionic liquid, cholinium-clindamycin phosphate, as sole chiral selector in capillary electrophoresis.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:31874700] [10.1016/j.chroma.2019.460721]

2. Ma Xiaofei, Du Yingxiang, Zhu Xinqi, Feng Zijie, Chen Cheng, Yang Jiangxia.  (2019)  Evaluation of an ionic liquid chiral selector based on clindamycin phosphate in capillary electrophoresis.  ANALYTICAL AND BIOANALYTICAL CHEMISTRY,  411  (22): (5855-5866).  [PMID:31286176] [10.1007/s00216-019-01967-z]

3. Guang-Ming Bao, Shun-Qiang Cui, Yi-Fan Xia, Zhen-Chong Dou, Xia Wei, Zhi-Qiang Cai, Peiyao Chen, Yi Zhang, Yu-Xin Chen, Hou-Qun Yuan.  (2024)  Dual emissive Cl, N-codoped carbon dots for highly selective and sensitive detection of amphotericin B in milk and wastewater.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2024.111105]

4. Liufu Zhang, Jianwei Di, Haoyang Wang, Zhiwei Zhou, Yuxi Wang, Jun Long, Yanqiu Zhang, Jing Guo, Xu Jiang, Lu Shao.  (2025)  Tear-film-inspired interfacial polymerization engineering nanofiltration membrane architecture for highly efficient antibiotic desalination.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.164990]

5. Luyao Wang, Lei Du, Yuting Yang, Lulu Hu, Hao Yang, Zhe Zhai, Xiaoting Li, Shuaifei Zhao, Yuchao Zhao, Yan Huang.  (2026)  Boosting antibiotics separation performance of thin-film composite nanofiltration membranes via nanotube-intercalated nanosheet interlayer on a macro-porous substrate.  Journal of Water Process Engineering,      [PMID:] [10.1016/j.jwpe.2026.109680]