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COH34 - ≥99% , CAS No.906439-72-3
Disponible para pedir
GRADE & PURITY ≥99%
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
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Why this grade
≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors
In Vitro
COH34 efficiently kills PARP inhibitor-resistant cancer cells. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
COH34 induces lethality in cancer cells with DNA repair defects and exhibits antitumor activity in xenograft mouse cancer models . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:IC50: 0.37 nM (PARG)
Specifications
Especificaciones y pureza
≥99%
Mecanismos bioquímicos y fisiológicos
COH34 is a potent and specific poly(ADP-ribose) glycohydrolase (PARG) inhibitor with an IC 50 of 0.37 nM. COH34 binds to the catalytic domain of PARG ( K d =0.547 μM), thereby prolonging PARylation at DNA lesions and trapping DNA repair factors.
Condiciones de almacenamiento de almacenamiento
Store at -20°C
Enviado en
Ice chest + Ice pads
Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.
Pureza
≥99%
Nombres e identificadores
| Sonrisas canónicas | CC1=CC=C(C=C1)SN=CC2=C(C=CC3=CC=CC=C32)O |
|---|---|
| IUPAC Name | 1-[(E)-(4-methylphenyl)sulfanyliminomethyl]naphthalen-2-ol |
| InChIKey | SFUAIBHPGDRCFL-XDHOZWIPSA-N |
| INCHI | 1S/C18H15NOS/c1-13-6-9-15(10-7-13)21-19-12-17-16-5-3-2-4-14(16)8-11-18(17)20/h2-12,20H,1H3/b19-12+ |
| PubChem CID | 135443632 |
| Número NSC | 191252 |
| Peso molecular | 293.38 |
Documentation
📋 Safety Data Sheet (SDS)
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →✅ Certificate of Analysis (COA)
Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →🔬 Specification Sheet
Full quality attributes and acceptance criteria for this grade.
View spec sheet →Advanced Data
Estructura 3D
Modelo de Estructura Química Interactiva
Certificados (CoA, COO, BSE/TSE y tabla de análisis)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Propiedades químicas y físicas
| Solubilidad | DMSO : 16.67 mg/mL (56.82 mM; Need ultrasonic) |
|---|
Calculadoras de soluciones
Reseñas
Reseñas de cliente
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