Coralyne chloride - ≥98.0% , CAS No.38989-38-7
Disponible
SKU
C649983
Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes
In Vitro
Coralyne (6.25-100 μM; 24-72 hours) has cytotoxicity effect on breast cancer cell lines. It against MCF-7, MDA-MB-231 and MCF-10A cells with IC 50 s of 76.4 uM, 76.4 uM, and 99 uM,respectively at 24 hours. And it against MCF-7, MDA-MB-231 and MCF-10A cells with IC 50 s of 21.9 uM, 19.1 uM, and 91 μM, respectively at 72 hours. Coralyne (25 μM; 48 hours) significantly downregulates cancer cell attachment of MCF-7 and MDA-MB-231 compared to the untreated controls. The percent of reduction in adhesion of MCF-7 is 55%, whereas 53% in reduction in the adhesion of MDA-MB-23 and 62% in reduction of MCF-10A,respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:Topoisomerase I
Más Información
| CAS | 38989-38-7 |
|---|---|
| Sinónimos | ?NSC-154890 | NSC96349 | NSC-96349 | Dibenzo(a,g)quinolizinium, 2,3,10,11-tetramethoxy-8-methyl-, chloride | Coralyne chloride | NSC154891 | NSC-154891 | NCGC00094866-01 | SR-05000002641-1 | DTXSID50959832 | BERBINIUM, 5,6,7,8,13,13a-HEXADEHYDRO-2,3,10,11 |
| Especificaciones y pureza | ≥98.0% |
| Condiciones de almacenamiento de almacenamiento | Store at 2-8°C,Argon charged,Desiccated |
| Enviado en | Wet ice |
| Product Description | Coralyne chloride is a protoberberine alkaloid with potent anti-cancer activities. Coralyne chloride acts as a potent topoisomerase I poison and induces Top I mediated DNA cleavage Coralyne chloride can be used for preparing coralyne derivatives as DNA binding fluorescent probes In Vitro Coralyne (6.25-100 μM; 24-72 hours) has cytotoxicity effect on breast cancer cell lines. It against MCF-7, MDA-MB-231 and MCF-10A cells with IC 50 s of 76.4 uM, 76.4 uM, and 99 uM,respectively at 24 hours. And it against MCF-7, MDA-MB-231 and MCF-10A cells with IC 50 s of 21.9 uM, 19.1 uM, and 91 μM, respectively at 72 hours. Coralyne (25 μM; 48 hours) significantly downregulates cancer cell attachment of MCF-7 and MDA-MB-231 compared to the untreated controls. The percent of reduction in adhesion of MCF-7 is 55%, whereas 53% in reduction in the adhesion of MDA-MB-23 and 62% in reduction of MCF-10A,respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Form:Solid IC50& Target:Topoisomerase I |
| Pubchem Sid | 528763937 |
| Solubilidad | H2O : 4 mg/mL (10.00 mM; ultrasonic and warming and heat to 60°C) DMSO : 1.82 mg/mL (4.55 mM; ultrasonic and warming and heat to 60°C) |
| Sensibilidad | Moisture sensitive |
| Número CE | 254-239-2 |
| PubChem CID | 23306 |
Reseñas
Reseñas de cliente
Remind me later