GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.≥98%
Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 5 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Descripción general
Dehydroepiandrosterone sulfate is a neurosteroid and a major adrenal secretion product. It has both non-competitive antagonist activity at GABAA receptors and agonist activity at σ1 receptors. It can partially penetrate the blood-brain barrier, inhibit GABAA receptor-mediated chloride ion influx, enhance NMDA receptor activity through σ1 receptors, exert anti-inflammatory, anti-glucocorticoid, and increase seizure sensitivity. It participates in neuroprotection, regulation of neurite outgrowth, and catecholamine secretion, and may also serve as a biomarker for cardiovascular disease mortality.
This compound belongs to the class of organic compounds known as sulfated steroids. These are sterol lipids containing a sulfate group attached to the steroid skeleton.
External Descriptors
Sulfates
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
1.Huiyi Yang, Qiyi He, Mingxia Lin, Li Ji, Leheng Zhang, Huanxin Xiao, Shijia Li, Qinglan Li, Xiping Cui, Suqing Zhao. (2022) Multifunctional Au@Pt@Ag NPs with color-photothermal-Raman properties for multimodal lateral flow immunoassay. JOURNAL OF HAZARDOUS MATERIALS, [PMID:35650752][10.1016/j.jhazmat.2022.129082]
2.Huiyi Yang, Qiyi He, Junkang Pan, Mingxia Lin, Zhiting Lao, Qinglan Li, Xiping Cui, Suqing Zhao. (2021) PtCu nanocages with superior tetra-enzyme mimics for colorimetric sensing and fluorescent sensing dehydroepiandrosterone. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:][10.1016/j.snb.2021.130905]
3.Yang Huiyi, He Qiyi, Eremin Sergei A., Pan Junkang, Zou Yikui, Cui Xiping, Zhao Suqing. (2021) Fluorescence polarization immunoassay for rapid determination of dehydroepiandrosterone in human urine. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 413 (17):(4459-4469). [PMID:34137913][10.1007/s00216-021-03403-7]
4.Yang Huiyi, He Qiyi, Chen Yingshan, Shen Ding, Xiao Huanxin, Eremin Sergei A., Cui Xiping, Zhao Suqing. (2020) Platinum nanoflowers with peroxidase-like property in a dual immunoassay for dehydroepiandrosterone. MICROCHIMICA ACTA, 187 (11):(1-12). [PMID:33025211][10.1007/s00604-020-04528-9]
5.Xiao Xina, Hu Meng, Gao Li, Yuan Huan, Chong Baochen, Liu Yu, Zhang Rou, Gong Yanqiu, Du Dan, Zhang Yong, Yang Hao, Liu Xiaohui, Zhang Yan, Zhang Huiyuan, Xu Heng, Zhao Yi, Meng Wenbo, Xie Dan, Lei Peng, Qi Shiqian, Peng Yong, Tan Tao, Yu Yang, Hu Hongbo, Dong Biao, Dai Lunzhi. (2025) Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut. Signal Transduction and Targeted Therapy, 10 (1):(1-18). [PMID:39774148][10.1038/s41392-024-02094-7]
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