Disulfiram (NSC 190940)（TETD） - Moligand™, 10mM in DMSO , Aldehyde dehydrogenase inhibitor, CAS No.97-77-8, Aldehyde dehydrogenase inhibitor

CAS: 97-77-8 Cat. No.: D408480 Peso molecular: 296.54 Beilstein Registry Number: 1712560 Número EC: 202-607-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Tetraethylthiuram disulfide, TETD | N,​N,​N',​N'-​tetraethyl-thioperoxydicarbonic diamide([(H2N)​C(S)​]​2S2)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Descripción general

Information

Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD) is a specific inhibitor ofaldehyde-dehydrogenase (ALDH)with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by producing
In vitro

Disulfiram-copper complex potently inhibits the proteasomal activity in cultured breast cancer MDA-MB-231 and MCF10DCIS.com cells, but not normal, immortalized MCF-10A cells, before induction of apoptotic cancer cell death. ^[1] Disulfiram (DS), a clinically used anti-alcoholism drug, strongly inhibits constitutive and 5-FU-induced NF-kappaB activity in a dose-dependent manner. Disulfiram inhibits both NF-kappaB nuclear translocation and DNA binding activity but has no effect on 5-FU-induced IkappaBalpha degradation. Disulfiram significantly enhances the apoptotic effect of 5-FU on DLD-1 and RKO(WT) cell lines and synergistically potentiated the cytotoxicity of 5-FU to both cell lines. Disulfiram also effectively abolishes 5-FU chemoresistance in a 5-FU resistant cell line H630(5-FU) in vitro. ^[2] Oseltamivir decreases the number of viable cells, and the addition of CuCl(2) significantly enhances the DSF-induced cell death to less than 10% of control. ^[3] Disulfiram given to melanoma cells in combination with Cu2+ or Zn2+ decreases expression of cyclin A and reduces proliferation in vitro at lower concentrations than disulfiram alone. ^[4]

In vivo

Disulfiram significantly inhibits the tumor growth (by 74%), associated with in vivo proteasome inhibition (as measured by decreased levels of tumor tissue proteasome activity and accumulation of ubiquitinated proteins and natural proteasome substrates p27 and Bax) and apoptosis induction (as shown by caspase activation and apoptotic nuclei formation) in mice bearing MDA-MB-231 tumor xenografts. ^[1] Disulfiram blocks the P-glycoprotein extrusion pump, inhibits the transcription factor nuclear factor-kappaB, sensitizes tumors to chemotherapy, reduces angiogenesis, and inhibits tumor growth in mice. Disulfiram inhibits growth and angiogenesis in melanomas transplanted in severe combined immunodeficient mice, and these effects are potentiated by Zn2+ supplementation. ^[4]
Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥98%

Specifications

Sinónimos

Tetraethylthiuram disulfide, TETD | N, ​N, ​N', ​N'-​tetraethyl-thioperoxydicarbonic diamide([(H2N)​C(S)​]​2S2)

Especificaciones y pureza

Moligand™, 10mM in DMSO

Mecanismos bioquímicos y fisiológicos

Disulfiram (NSC 190940, Tetraethylthiuram disulfide, TETD) is a specific inhibitor of aldehyde-dehydrogenase (ALDH) with IC50 of 0.15 μM and 1.45 μM for hALDH1 and hALDH2, respectively. Disulfiram is used for the treatment of chronic alcoholism by produci

Condiciones de almacenamiento de almacenamiento

Store at -80°C

Enviado en

Dry ice packs + Cold packs

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Moligand™

Tipo de acción

INHIBITOR

Mecanismo de acción

Aldehyde dehydrogenase inhibitor

Propiedades del producto

• ALogP: 3.9

Nombres e identificadores

• Isómeros SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC
• WGK Alemania: 3
• RTECS: JO1225000
• Peso molecular: 296.54
• Beilstein: 1712560
• Reaxy-Rn: 1712560
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1712560&ln=

Objetivos asociados (humanos)

CYP2C19 Tchem Cytochrome P450 2C19 (1 Activities)

Discover Target: CYP2C19

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

EHMT2 Tchem Histone-lysine N-methyltransferase EHMT2 (1 Activities)

Discover Target: EHMT2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

FBP1 Tchem Fructose-1,6-bisphosphatase 1 (1 Activities)

Discover Target: FBP1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CYP2C9 Tchem Cytochrome P450 2C9 (1 Activities)

Discover Target: CYP2C9

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

TRPA1 Tclin Transient receptor potential cation channel subfamily A member 1 (1 Activities)

Discover Target: TRPA1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

MGLL Tchem Monoglyceride lipase (1 Activities)

Discover Target: MGLL

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LOXL2 Tchem Lysyl oxidase homolog 2 (1 Activities)

Discover Target: LOXL2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LOXL3 Tchem Lysyl oxidase homolog 3 (1 Activities)

Discover Target: LOXL3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LOX Tchem Protein-lysine 6-oxidase (1 Activities)

Discover Target: LOX

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

LOXL4 Tchem Lysyl oxidase homolog 4 (1 Activities)

Discover Target: LOXL4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH1A1 Tchem Retinal dehydrogenase 1 (1 Activities)

Discover Target: ALDH1A1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ALDH2 Tclin Aldehyde dehydrogenase, mitochondrial (1 Activities)

Discover Target: ALDH2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

GSDMD Tchem Gasdermin-D (1 Activities)

Discover Target: GSDMD

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Propiedades químicas y físicas

• Solubilidad: Solubility (25°C) In vitro DMSO: 26 mg/mL (201.37 mM); Water: 26 mg/mL (201.37 mM); Ethanol: 26 mg/mL (201.37 mM)
• Punto de fusión (°C): 69-71°C

Referencias

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15. Xiangyu Meng, Jiayi Wu, Zunfu Hu, Xiuwen Zheng, Zhifei Wang.  (2024)  Coordinating effect of ferroptosis and in situ disulfiram toxification for enhanced cancer therapy.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2024.149313]

16. Shang Chi, Yaping Li, Tingting Ye, Jiawei Kang, Zhihui Xiang, Xiaoqing Kuang, Chenggang Yi, Yiying Qi, Wei Wang.  (2025)  Energy reconversion of ultrasound on a piezoelectric hydrogel promotes ROS/CO generation and wound self-closure for infected chronic wound healing.  Matter,      [PMID:] [10.1016/j.matt.2025.101989]

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18. Xiangyu Zuo, Hongxiang Yu, Feng Zhou, Xia Zhang.  (2025)  Synergistic Lubrication Achieved by Proton-Ionic Liquids and MoS2 as High-Performance Water-Based Lubricant Additives.  LANGMUIR,      [PMID:39973513] [10.1021/acs.langmuir.4c05246]

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21. Yuqin Chen, Zixia Hu, Guode Zhao, Mei Li, Ziying Jiang, Liangjia Xu, Jiannan Zheng, Weiwei Li, Ying Peng, Jiang Zheng.  (2025)  Metabolic activation, hepatic protein covalent binding, and cytotoxicity of arctigenin.  TOXICOLOGY LETTERS,      [PMID:41325899] [10.1016/j.toxlet.2025.111785]

22. Xinzi He, Yaping Li, Zhihui Xiang, Yifan Wu, Jinfeng Zhou, Peng Tang, Xiaoxiao Ji, Zhongming Huang, Jianbin Xu, Wei Wang, Yiying Qi.  (2026)  Sonocatalytic multifunctional hydrogel in-situ remodels the infectious microenvironment for eradicating refractory osteomyelitis.  JOURNAL OF CONTROLLED RELEASE,      [PMID:41655907] [10.1016/j.jconrel.2026.114686]

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