DMT-2′O-TBDMS-rA(bz) Phosphoramidite - ≥97% , CAS No.104992-55-4

CAS: 104992-55-4 Cat. No.: B189502 Peso molecular: 988.19

GRADE & PURITY ≥97%

Synonyms

Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N,N-bis(1-methylethyl)phosphoramidite] | PD158240 | SCHEMBL667192 | DMT-2'O-TBDMS-rA(bz) Pharmadite(R) | N-Benzoyl-5'-O-(4,4-Dimethoxyt

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Descripción general

RNA phosphoramidites, along with RNA CPG, and analogous to DNA synthesis support the synthesis of sequence-specific RNA oligonucleotides for RNA interference (RNAi) and can be used in target validation and other drug development techniques.Modern phosphoramidite-mediated synthesis has enabled routine high-yielding preparations of RNA oligonucleotides. High-quality RNA phosphoramidites are key to low failure rates, the high biological activity of synthesis products, and cost-effectiveness.Key Features

Industry-standard 2′O-TBDMS protective group

Consistent lot-to-lot purity and performance

Compatible with deprotection methods based on methylamine or AMA

Standard RNA phosphoramidites provide excellent coupling results whenused with ETT or BTT as an activator; best results are obtained withActivator 42

Capping with standard acetic anhydride capping reagent rather than withFast Deprotection Cap A

Manufactured under a certified ISO 9001 quality systemDMT-2′O-TBDMS-rA(bz) Phosphoramidite is configured for MerMade Synthesizers.

Specifications

Sinónimos

Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1, 1-dimethylethyl)dimethylsilyl]-, 3'-[2-cyanoethyl N, N-bis(1-methylethyl)phosphoramidite] | PD158240 | SCHEMBL667192 | DMT-2'O-TBDMS-rA(bz) Pharmadite(R) | N-Benzoyl-5'-O-(4, 4-Dimethoxyt

Especificaciones y pureza

≥97%

Condiciones de almacenamiento de almacenamiento

Store at -20°C

Enviado en

Ice chest + Ice pads

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Pureza

≥97%

Nombres e identificadores

• Pubchem Sid: 504766329
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504766329
• Sonrisas canónicas: CC(C)N(C(C)C)P(OCCC#N)OC1C(OC(C1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
• IUPAC Name: N-[9-[(2R,3R,4R,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-[tert-butyl(dimethyl)silyl]oxy-4-[2-cyanoethoxy-[di(propan-2-yl)amino]phosphanyl]oxyoxolan-2-yl]purin-6-yl]benzamide
• InChIKey: FFXHNCNNHASXCT-RFMFGJHUSA-N
• INCHI: 1S/C53H66N7O8PSi/c1-36(2)60(37(3)4)69(65-32-18-31-54)67-46-44(33-64-53(39-21-16-13-17-22-39,40-23-27-42(62-8)28-24-40)41-25-29-43(63-9)30-26-41)66-51(47(46)68-70(10,11)52(5,6)7)59-35-57-45-48(55-34-56-49(45)59)58-50(61)38-19-14-12-15-20-38/h12-17,19-30,34-37,44,46-47,51H,18,32-33H2,1-11H3,(H,55,56,58,61)/t44-,46-,47-,51-,69?/m1/s1
• Isómeros SMILES: CC(C)N(C(C)C)P(OCCC#N)O[C@@H]1[C@H](O[C@H]([C@@H]1O[Si](C)(C)C(C)(C)C)N2C=NC3=C(N=CN=C32)NC(=O)C4=CC=CC=C4)COC(C5=CC=CC=C5)(C6=CC=C(C=C6)OC)C7=CC=C(C=C7)OC
• Peso molecular: 988.19
• Reaxy-Rn: 45611722
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=45611722&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Clase Triphenyl compounds

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Clase: Triphenyl compounds
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Triphenyl compounds
• Alternative Parents: Ribonucleoside phosphoramidites Glycosylamines Benzamides Purines and purine derivatives Benzylethers Anisoles Phenoxy compounds Benzoyl derivatives Methoxybenzenes Alkyl aryl ethers Pyrimidines and pyrimidine derivatives Imidolactams Monosaccharides N-substituted imidazoles Trialkylheterosilanes Oxolanes Heteroaromatic compounds Silyl ethers Secondary carboxylic acid amides Azacyclic compounds Dialkyl ethers Oxacyclic compounds Organic metalloid salts Nitriles Hydrocarbon derivatives Organopnictogen compounds Organic oxides
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Triphenyl compound - Ribonucleoside phosphoramidite - N-glycosyl compound - Glycosyl compound - Benzamide - Purine - Imidazopyrimidine - Benzoic acid or derivatives - Benzylether - Phenoxy compound - Anisole - Phenol ether - Benzoyl - Methoxybenzene - Alkyl aryl ether - Pyrimidine - Monocyclic benzene moiety - Monosaccharide - Imidolactam - N-substituted imidazole - Imidazole - Trialkylheterosilane - Oxolane - Heteroaromatic compound - Azole - Secondary carboxylic acid amide - Silyl ether - Carboxamide group - Organoheterosilane - Oxacycle - Azacycle - Carboxylic acid derivative - Dialkyl ether - Ether - Organic metalloid salt - Organoheterocyclic compound - Carbonitrile - Nitrile - Organopnictogen compound - Cyanide - Organic nitrogen compound - Organic oxide - Hydrocarbon derivative - Organosilicon compound - Organooxygen compound - Organonitrogen compound - Organic metalloid moeity - Organic oxygen compound - Aromatic heteropolycyclic compound
• Descripción: This compound belongs to the class of organic compounds known as triphenyl compounds. These are aromatic compounds containing a triphenyl moiety.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Propiedades químicas y físicas

• Peso molecular: 988.200 g/mol
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 13
• Rotatable Bond Count: 22
• Exact Mass: 987.448 Da
• Monoisotopic Mass: 987.448 Da
• Topological Polar Surface Area: 164.000 Ų
• Heavy Atom Count: 70
• Formal Charge: 0
• Complexity: 1630.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 1
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

XLogP3