Doxycycline hyclate - analytical standard , CAS No.24390-14-5

CAS: 24390-14-5 Cat. No.: D111942 Peso molecular: 512.94 Beilstein Registry Number: 5702728 Número EC: 657-194-0 PubChem CID: 54686183

GRADE & PURITY Analytical standard

Synonyms

Doxycycline hydrochloride hydrate (JP17) | Periostat | AKOS025402170 | DOXYCYCLINE HYCLATE [VANDF] | DOXYCYCLINE HYCLATE [ORANGE BOOK] | Doxycycline hyclate 100 microg/mL in Acetonitrile | trans-1,3-Pentadiene, analytical standard | Doxycycline hyclate (i

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Sinónimos

Doxycycline hydrochloride hydrate (JP17) | Periostat | AKOS025402170 | DOXYCYCLINE HYCLATE [VANDF] | DOXYCYCLINE HYCLATE [ORANGE BOOK] | Doxycycline hyclate 100 microg/mL in Acetonitrile | trans-1, 3-Pentadiene, analytical standard | Doxycycline hyclate (i

Especificaciones y pureza

analytical standard

Condiciones de almacenamiento de almacenamiento

Store at 2-8°C

Enviado en

Wet ice

Este producto requiere envío en cadena de frío. Los servicios terrestres y otros servicios económicos no están disponibles.

Grado

Analytical standard

Nombres e identificadores

• Sonrisas canónicas: CCO.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.CC1C2C(C3C(C(=O)C(=C(C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
• IUPAC Name: (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;ethanol;hydrate;dihydrochloride
• InChIKey: UHHHTIKWXBRCLT-VDBOFHIQSA-N
• INCHI: 1S/2C22H24N2O8.C2H6O.2ClH.H2O/c2*1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;1-2-3;;;/h2*4-7,10,14-15,17,25-27,30,32H,1-3H3,(H2,23,31);3H,2H2,1H3;2*1H;1H2/t2*7-,10+,14+,15-,17-,22-;;;;/m00..../s1
• Isómeros SMILES: CCO.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.C[C@@H]1[C@H]2[C@@H]([C@H]3[C@@H](C(=O)C(=C([C@]3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)O)C(=O)N)N(C)C)O.O.Cl.Cl
• WGK Alemania: 3
• RTECS: QI8925000
• CAS alternativo: 10592-13-9
• PubChem CID: 54686183
• Peso molecular: 512.94
• Beilstein: 5702728

Mecanismos de acción

Propiedades químicas y físicas

• Rotación específica [α]: -104° (C=1,0.01mol/L HCl(MeOH))
• Peso molecular: 1025.900 g/mol
• Hydrogen Bond Donor Count: 16
• Hydrogen Bond Acceptor Count: 20
• Rotatable Bond Count: 4
• Exact Mass: 1024.31 Da
• Monoisotopic Mass: 1024.31 Da
• Topological Polar Surface Area: 384.000 Ų
• Heavy Atom Count: 70
• Formal Charge: 0
• Complexity: 958.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 12
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 6

XLogP3

Referencias

1. Guanhua Liu, Luting Wang, Anan Zhao, Leijie Guo, Liya Zhou, Ying He, Li Ma, Yunting Liu, Jing Gao, Yanjun Jiang.  (2023)  Biocatalytic membranes with crosslinked enzyme aggregates for micropollutant removal.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2023.147635]

2. Fuhua Wei, Meng Nie, Qinhui Ren, Xiang Yu, Hua Li, Hongliang Chen, Mengting He, Zhao Liang, Siyuan Wang, Dongxue Han.  (2023)  Preparation of bimetallic metal–organic frameworks for adsorbing doxycycline hydrochloride from wastewater.  APPLIED ORGANOMETALLIC CHEMISTRY,  37  (9): (e7212).  [PMID:] [10.1002/aoc.7212]

3. Dong Wang, Yumeng Wang, Luheng Jing, Lei Wang, Tonghui Zhang, Xuefen Wang.  (2023)  L-phenylalanine-assisted construction of hierarchically structured Fe(OH)3@Co2(OH)2CO3 with enhanced catalytic activities for the degradation of persistent organic pollutants.  Journal of Cleaner Production,      [PMID:] [10.1016/j.jclepro.2023.138220]

4. Yating Wang, Chaosheng Peng, Airu Liu, Jinyue Song, Xingang Li, Tao Jiang.  (2022)  Novel intramolecular-tailored g-C3N4 with accelerated charge delivery for photocatalytic tetracycline degradation and hydrogen production: experimental studies and theoretical analyses.  Journal of Materials Chemistry C,  11  (3): (1165-1172).  [PMID:] [10.1039/D2TC04350E]

5. Cheng He, Jiaxin Ma, Huan Xu, Changzi Ge, Ziru Lian.  (2022)  Selective capture and determination of doxycycline in marine sediments by using magnetic imprinting dispersive solid-phase extraction coupled with high performance liquid chromatography.  MARINE POLLUTION BULLETIN,      [PMID:36307947] [10.1016/j.marpolbul.2022.114215]

6. Dong Wang, Yumeng Wang, Xuefen Wang.  (2022)  Heterostructured ZIF-67@α-MnO2 based nanofibrous membranes for highly effective removal of low-molecular-weight pollutants from wastewater.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2022.122225]

7. Yan-Mei Liang, Hui Yang, Bo Zhou, Yang Chen, Min Yang, Ke-Su Wei, Xiu-Fang Yan, Chao Kang.  (2021)  Waste tobacco leaves derived carbon dots for tetracycline detection: Improving quantitative accuracy with the aid of chemometric model.  ANALYTICA CHIMICA ACTA,      [PMID:35033278] [10.1016/j.aca.2021.339269]

8. Yijian Zhao, Qinzhi Wang, Haihua Wang, Hui Zhangsun, Xinyu Sun, Tong Bu, Yingnan Liu, Wenze Wang, Zhihao Xu, Li Wang.  (2021)  Europium-based metal-organic framework containing characteristic metal chains: A novel turn-on fluorescence sensor for simultaneous high-performance detection and removal of tetracycline.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2021.129610]

9. Yanmin Shen, Wenju Liu, Chen Sun, Paifeng Shi.  (2020)  Solubility Measurement and Correlation of Doxycycline Hyclate in 10 Pure Solvents and Mixtures Solvents at 278.15–323.15 K.  JOURNAL OF CHEMICAL AND ENGINEERING DATA,      [PMID:] [10.1021/acs.jced.0c00097]

10. Junjian Chen, Xuetao Shi, Ye Zhu, Yunhua Chen, Meng Gao, Huichang Gao, Lei Liu, Lin Wang, Chuanbin Mao, Yingjun Wang.  (2020)  On-demand storage and release of antimicrobial peptides using Pandora's box-like nanotubes gated with a bacterial infection-responsive polymer.  Theranostics,      [PMID:31903109] [10.7150/thno.38388]

11. Yanmin Shen, Wenju Liu, Zehua Bao.  (2019)  Solubility measurement and thermodynamic modeling of Doxycycline Hyclate two binary solvent systems at 276.95–323.75 K.  JOURNAL OF MOLECULAR LIQUIDS,      [PMID:] [10.1016/j.molliq.2019.111138]

12. Yan Zhao, Lianfang Chen, Fenglin Tang, Lilei Zhang, Qiang Yang, Xiupei Yang.  (2025)  Boosting peroxymonosulfate activation for complete removal of gatifloxacin by a bead-chain zeolitic imidazolate framework composite.  JOURNAL OF COLLOID AND INTERFACE SCIENCE,      [PMID:39837247] [10.1016/j.jcis.2025.01.102]

13. Liting Yang, Zhaoxiao Hao, Yue Yin, Lijian Du, Xiangyu Liu, Huan Zhang, Jinfang Wu, Fang Guo, Jian Liu, Wenbo Wang.  (2025)  Coadsorbent boosts Caragana-derived carbon for breakthrough antibiotic capture in a robust nanosheet-on-carbon architecture.  Journal of Environmental Chemical Engineering,      [PMID:] [10.1016/j.jece.2025.116426]

14. Yue Zhou, Yuanyuan Jiang, Xiangyu Chen, Hongchen Long, Mao Zhang, Zili Tang, Yufang He, Lei Zhang, Tao Le.  (2024)  Enhanced Sensitivity and Accuracy of Tb3+-Functionalized Zirconium-Based Bimetallic MOF for Visual Detection of Malachite Green in Fish.  Foods,  13  (17): (2855).  [PMID:39272620] [10.3390/foods13172855]

15. Zhaofeng Wang, Hui Xu, Lihua Wang, Xinxiang Zheng, Tengzhi Zhao, Bowen Qu, Hua Wang.  (2025)  Highly-sensitive ratiometric determination of tetracyclines and smartphone-assisted visual assay by carrot-derived nitrogen-doped carbon dots-europium ion dual-emission fluorescence probe.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.113398]

16. Yuchi Zhang, Le Han, Bohan Li, Yan Xu.  (2024)  High-performance ratiometric fluorescence detection and removal of tetracycline in milk based on CDs@ZSM-5:Eu3+.  FOOD CHEMISTRY,      [PMID:39340904] [10.1016/j.foodchem.2024.141441]

17. Hongchao Dai, Lei Yuan, Luyao Fan, Jia Yang, Xinan Jiao.  (2024)  Occurrence and risk-related features of Bacillus cereus in fluid milk.  INTERNATIONAL JOURNAL OF DAIRY TECHNOLOGY,      [PMID:] [10.1111/1471-0307.13054]

18. Tiantian Wang, Lingfeng Zhao, Guanhua Liu, Xiaoyang Yue, Xiaobing Zheng, Li Ma, Yunting Liu, Mimi Chen, Yanjun Jiang.  (2025)  Preparation of SCOF/UiO-66-NH2 immobilized laccase biocatalytic membrane for micropollutants removal from water.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.161310]

19. He Ying, Li Wei, Zhang Meiling, Wang Hui, Lin Peilu, Yu Ying, Huang Bin, Hao Meng, He Jianuo, Kong Weiyao, Luo Dan, Xu Tengteng, Wang Jiaqi, Huang Ying, Zhao Qinwen, Liu Ying, Zhang Jie, Nian Yong, Zhang Lei, Zhu Bo, Yin Chengqian.  (2025)  PTPN23-dependent activation of PI3KC2α is a therapeutic vulnerability of BRAF-mutant cancers.  JOURNAL OF EXPERIMENTAL MEDICINE,  222  (3): (e20241147).  [PMID:39841180] [10.1084/jem.20241147]

20. Dong Wang, Siping Ding, Zhenzhen He, Tonghui Zhang, Xuefen Wang.  (2024)  Tailor-made Co3O4@CeO2 based nanofibrous membrane with enhanced catalytic reactivity for efficient degradation of antibiotic.  COMPOSITES PART B-ENGINEERING,      [PMID:] [10.1016/j.compositesb.2024.111424]

21. Zhen-Wen Zhang, Ao-Jun Qiu, Geng-Jin-Sheng Cheng, Yu Fan, Yu Xiao, Yan-Zhu Liu, Qian-Yong Cao.  (2025)  A novel Eu(III)-based nano-aggregation for ratiometric fluorescence sensing of tetracycline.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2025.114507]

22. Yue Jin, Yi Chen, Dayu Zhou, Li Wu, Haolan Zhang, Jinchuan Gu.  (2025)  One-step hydrothermal synthesis of lithium slag-based zeolite for the ultrafast photocatalytic degradation of tetracycline.  JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY,      [PMID:] [10.1016/j.jphotochem.2025.116783]

23. Zhao Tengzhi, Wang Zhaofeng, Zhang Runke, Xu Hui, Wang Hua, Yu Ying.  (2025)  Carrot-Derived Nitrogen-Doped Dual-Emission Carbon Dots for Ratiometric Detection of Tetracycline and Oxytetracycline.  JOURNAL OF FLUORESCENCE,      [PMID:40924358] [10.1007/s10895-025-04531-4]

24. Dian Li, Yun Chen, Shangbin Kao, Canlong Yan, Tianyu Zheng, Yuan Qin, Xiumei Zhou, Xiang Shao, Biao Huang.  (2025)  Establishment and Application of a Method for Detecting Tetracycline Antibiotics in Milk Based on AlphaLICA Technology.  Analytical Methods,      [PMID:41493018] [10.1039/D5AY01720C]

25. Zhike Wang, Yanan Chen, Cunling Ye.  (2025)  Transforming β-cyclodextrin into a non-conventional luminophore via H2O2 oxidation and its application in detection of tetracyclines.  Journal of the Taiwan Institute of Chemical Engineers,      [PMID:] [10.1016/j.jtice.2025.106437]

26. Huang Junshi, Huang Bolin, Huang Shuanggen, Wang Xiaobin, Zhao Jinhui.  (2026)  Design and predictive modeling of a veterinary drug detection sensor in paddy field water based on artificial neural networks.  Scientific Reports,      [PMID:41688517] [10.1038/s41598-026-38752-9]