≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.
Appearance:Solid
IC50& Target:GADD45β/MKK7
In Vitro:DTP3 (10 μM; 1-21 days) causes the potent and tumor-selective induction of JNK activation and apoptosis, as shown by the appearance of phosphorylated JNK, as early as 24 hours. MCE has not independently confirmed the accuracy of these methods. They a
In Vivo:DTP3 TFA (s.c.; 14.5mg/kg/day; 28 days) has shown a dramatic shrinkage of the tumors, and virtually eradicates established subcutaneous myeloma xenografts in mice. DTP3 TFA (intravenous injection; 10mg/kg/day) has t 1/2 of 1.26 hours, CL of 27.13 M
Biological Activity:DTP3 TFA is a potent and selective GADD45β/MKK7 (growth arrest and DNA-damage-inducible β/mitogen-activated protein kinase kinase 7) inhibitor. DTP3 TFA targets an essential, cancer-selective cell-survival module downstream of the NF-κB pathway.
| CAS alternativo | 1809784-29-9 |
|---|
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
 G2411169 | Certificate of Analysis | Jan 20, 2026 | D659121 |
| G2411170 | Certificate of Analysis | Jan 20, 2026 | D659121 |
| G2411171 | Certificate of Analysis | Jan 20, 2026 | D659121 |
| G2411172 | Certificate of Analysis | Jan 20, 2026 | D659121 |
| G2411173 | Certificate of Analysis | Jan 20, 2026 | D659121 |
| Solubilidad | H2O : 100 mg/mL (156.34 mM; Need ultrasonic) DMSO : 50 mg/mL (78.17 mM; Need ultrasonic) |
|---|---|
| Sensibilidad | Moisture、Light sensitive |
