Determine the necessary mass, volume, or concentration for preparing a solution.
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Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Protected from light,Argon charged,Room temperature Ships Normal Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 32 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
It plays an important role as an antioxidant and is also used as a flavoring agent, in perfumes, and in organic synthesis. It holds anti-angiogenic, anti-inflammatory and antinociceptive properties.
| Pubchem Sid | 488180803 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/488180803 |
| Sonrisas canónicas | CCOC1=C(C=CC(=C1)C=O)O |
| IUPAC Name | 3-ethoxy-4-hydroxybenzaldehyde |
| InChIKey | CBOQJANXLMLOSS-UHFFFAOYSA-N |
| INCHI | 1S/C9H10O3/c1-2-12-9-5-7(6-10)3-4-8(9)11/h3-6,11H,2H2,1H3 |
| Isómeros SMILES | CCOC1=C(C=CC(=C1)C=O)O |
| WGK Alemania | 3 |
| RTECS | CU6125000 |
| Peso molecular | 166.17 |
| Beilstein | 1073761 |
| Reaxy-Rn | 1073761 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1073761&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic oxygen compounds |
| Clase | Organooxygen compounds |
| Subclass | Carbonyl compounds |
| Intermediate Tree Nodes | Aldehydes - Aryl-aldehydes - Benzaldehydes |
| Direct Parent | Hydroxybenzaldehydes |
| Alternative Parents | Phenoxy compounds Phenol ethers Benzoyl derivatives Alkyl aryl ethers 1-hydroxy-2-unsubstituted benzenoids Organic oxides Hydrocarbon derivatives |
| Molecular Framework | Aromatic homomonocyclic compounds |
| Substituents | Hydroxybenzaldehyde - Phenoxy compound - Phenol ether - Benzoyl - 1-hydroxy-2-unsubstituted benzenoid - Phenol - Alkyl aryl ether - Benzenoid - Monocyclic benzene moiety - Ether - Organic oxide - Hydrocarbon derivative - Aromatic homomonocyclic compound |
| Descripción | This compound belongs to the class of organic compounds known as hydroxybenzaldehydes. These are organic aromatic compounds containing a benzene ring carrying an aldehyde group and a hydroxyl group. |
| External Descriptors | aromatic ether - phenols - benzaldehydes |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Fecha | Articulo |
|---|---|---|---|
| Certificate of Analysis | Dec 10, 2025 | E107635 | |
| Certificate of Analysis | Aug 29, 2025 | E107635 | |
| Certificate of Analysis | Aug 29, 2025 | E107635 | |
| Certificate of Analysis | Aug 29, 2025 | E107635 | |
| Certificate of Analysis | Aug 29, 2025 | E107635 | |
| Certificate of Analysis | Aug 29, 2025 | E107635 | |
| Certificate of Analysis | Apr 29, 2024 | E107635 | |
| Certificate of Analysis | Apr 29, 2024 | E107635 | |
| Certificate of Analysis | Apr 29, 2024 | E107635 | |
| Certificate of Analysis | Apr 29, 2024 | E107635 | |
| Certificate of Analysis | Feb 18, 2022 | E107635 | |
| Certificate of Analysis | Feb 18, 2022 | E107635 | |
| Certificate of Analysis | Feb 18, 2022 | E107635 | |
| Certificate of Analysis | Feb 18, 2022 | E107635 | |
| Certificate of Analysis | Feb 18, 2022 | E107635 | |
| Certificate of Analysis | Feb 18, 2022 | E107635 | |
| Certificate of Analysis | Feb 18, 2022 | E107635 |
| Solubilidad | Slightly soluble in water. Soluble in ethanol, ether, benzene. |
|---|---|
| Sensibilidad | Sensitive to air; sensitive to light |
| Punto de inflamación (°F) | 293 °F |
| Punto de inflamación (°C) | 145 °C |
| Punto de ebullición (°C) | 149-150°C |
| Punto de fusión (°C) | 78°C |
| Peso molecular | 166.170 g/mol |
| XLogP3 | 1.600 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 3 |
| Rotatable Bond Count | 3 |
| Exact Mass | 166.063 Da |
| Monoisotopic Mass | 166.063 Da |
| Topological Polar Surface Area | 46.500 Ų |
| Heavy Atom Count | 12 |
| Formal Charge | 0 |
| Complexity | 147.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 1 |
| 1. Yurong Zhuang, Chenchen Wang, Yong Wang, Yuhui Chen, Songqin Liu, Wei Wei. (2023) Colorimetric and surface-enhanced Raman scattering method for vanillin detection based on two types of reduced silver nanoparticles. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2023.134267] |
| 2. Chenghong Huang, Hong Tang, Xiaorong Huang, Hongjie Chen, Kang Yang, Qi Yin, Lin Zhang, Xia Li, Xue Mou, Shuangkou Chen, Yuchan Zhang, Yan Hu. (2023) Ethyl Vanillin Rapid Crystallization from Carboxymethyl Chitosan Ion-Switchable Hydrogels. Gels, 9 (4): (335). [PMID:37102947] [10.3390/gels9040335] |
| 3. Zhentao Li, Zhengzheng Liao, Jinfang Hu, Zilin Chen. (2023) In situ growth of imine-based covalent organic framework as stationary phase for high-efficiency electrochromatographic separation. JOURNAL OF CHROMATOGRAPHY A, [PMID:36881971] [10.1016/j.chroma.2023.463905] |
| 4. Ruixue Yangcheng, Yuntong Cui, Shuang Luo, Jiansu Ran, Jianjian Wang. (2023) Hierarchical pore-trapped and hydrogen-bonded phosphoric acid in Pd-supported zeolite for the efficient aqueous hydrodeoxygenation of lignin derivatives at ambient temperature. MICROPOROUS AND MESOPOROUS MATERIALS, [PMID:] [10.1016/j.micromeso.2023.112460] |
| 5. Weichen Wang, Tian Sheng, Shanshuai Chen, Zhiyu Xiang, Fangyuan Zhou, Wanbin Zhu, Hongliang Wang. (2022) Defect engineering of Metal-Organic Framework for highly efficient hydrodeoxygenation of lignin derivates in water. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2022.139711] |
| 6. Di Chen, Bin Wang, Xin-Li Xu, Man-Yu Zhang, Xin-Miao Bu, Sen Yang, Yanbo Luo, Xia Xu. (2022) Kapok fiber-supported liquid extraction for convenient oil samples preparations: A feasibility and proof-of-concept study. JOURNAL OF CHROMATOGRAPHY A, [PMID:36095972] [10.1016/j.chroma.2022.463480] |
| 7. Jiansu Ran, Ruixue YangCheng, Yuntong Cui, Jianjian Wang. (2022) Significant Promotion of Carboxyl Groups in Palladium Nanoparticles-Supported Biomass Carbon Catalysts for Efficient Low-Temperature Hydrodeoxygenation of Lignin Derivatives in Water. ACS Sustainable Chemistry & Engineering, [PMID:] [10.1021/acssuschemeng.2c00572] |
| 8. Li Minglei, Wang Dingzhong, Zhao Wuduo, Xi Hui, Xu Hengyi, Sun Shihao, Fu Yingjie, Zhang Shusheng, Mao Jian, Zhang Jianxun. (2022) Simultaneous determination of multiple flavorings in infant formula by direct analysis in real time-mass spectrometry. LWT-FOOD SCIENCE AND TECHNOLOGY, [PMID:] [10.1016/j.lwt.2022.113586] |
| 9. Zidan Zou, Chun Chen, Zhi Hu, Yue Shen, Zhen Fu, Wenchao Li, Yunxia Zhang, Haimin Zhang, Huijun Zhao, Guozhong Wang. (2022) Core shell hetero-structured SiO2@Ni/SiO2 catalyst for efficient aqueous-phase hydrogenation of bio-derived unsaturated compounds. FUEL, [PMID:] [10.1016/j.fuel.2022.123694] |
| 10. Ruixue Yangcheng, Jiansu Ran, Zhaohui Liu, Yuntong Cui, Jianjian Wang. (2022) Phosphoric acid-modified commercial kieselguhr supported palladium nanoparticles as efficient catalysts for low-temperature hydrodeoxygenation of lignin derivatives in water. GREEN CHEMISTRY, 24 (4): (1570-1577). [PMID:] [10.1039/D1GC04243B] |
| 11. Hao-Zhou Huang, Yue-Hua Cong, An Du, Bing Hu, Bao-Yan Zhang. (2021) Liquid crystalline dimers containing a cholesteryl group: chiral smectic phases and TGBA* phase. LIQUID CRYSTALS, [PMID:] [10.1080/02678292.2021.1900431] |
| 12. Lu Xiaowen, Guo Chunmu, Zhang Mingyang, Leng Leipeng, Horton J. Hugh, Wu Wei, Li Zhijun. (2021) Rational design of palladium single-atoms and clusters supported on silicoaluminophosphate-31 by a photochemical route for chemoselective hydrodeoxygenation of vanillin. Nano Research, 14 (11): (4347-4355). [PMID:] [10.1007/s12274-021-3857-2] |
| 13. Dongdong Wang, Wanbing Gong, Jifang Zhang, Miaomiao Han, Chun Chen, Yunxia Zhang, Guozhong Wang, Haimin Zhang, Huijun Zhao. (2021) Encapsulated Ni-Co alloy nanoparticles as efficient catalyst for hydrodeoxygenation of biomass derivatives in water. CHINESE JOURNAL OF CATALYSIS, [PMID:] [10.1016/S1872-2067(21)63828-7] |
| 14. Zhijun Li, Xiaowen Lu, Weiwei Sun, Leipeng Leng, Mingyang Zhang, Honghong Li, Lu Bai, Dundong Yuan, J. Hugh Horton, Qian Xu, Jun Wang. (2021) One-step synthesis of single palladium atoms in WO2.72 with high efficiency in chemoselective hydrodeoxygenation of vanillin. APPLIED CATALYSIS B-ENVIRONMENTAL, [PMID:] [10.1016/j.apcatb.2021.120535] |
| 15. Jing Yang, Shijie Xu, Jingkang Wang, Junbo Gong. (2020) Nucleation behavior of ethyl vanillin: Balance between chemical potential difference and saturation temperature. JOURNAL OF MOLECULAR LIQUIDS, [PMID:] [10.1016/j.molliq.2020.112609] |
| 16. Xin Fu, Dongliang Zhu, Lan Huang, Xiangyang Yan, Shaomin Liu, Chenghui Wang. (2019) Superparamagnetic core-shell dummy template molecularly imprinted polymer for magnetic solid-phase extraction of food additives prior to the determination by HPLC. MICROCHEMICAL JOURNAL, [PMID:] [10.1016/j.microc.2019.104169] |
| 17. Fanyong Yan, Xiaodong Sun, Ruiqi Zhang, Yingxia Jiang, Jinxia Xu, Junfu Wei. (2019) Enhanced fluorescence probes based on Schiff base for recognizing Cu2+ and effect of different substituents on spectra. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, [PMID:31174152] [10.1016/j.saa.2019.117222] |
| 18. Li-Xian Zhu, Qin-Bao Lin, Jia-Yi Li, Hong-Mei Zhu, Hong-Sheng Ma, Huai-Ning Zhong, Jing-Jing Pan. (2019) Sources of potassium permanganate consumption for food contact paper. Food Packaging and Shelf Life, [PMID:] [10.1016/j.fpsl.2019.100319] |
| 19. Rui Xiao, Xiaoting Zhang, Xiaona Zhang, Jiahua Niu, Minghua Lu, Xiuhua Liu, Zongwei Cai. (2017) Analysis of flavors and fragrances by HPLC with Fe3O4@GO magnetic nanocomposite as the adsorbent. TALANTA, [PMID:28213232] [10.1016/j.talanta.2017.01.065] |
| 20. Hao Wu, Jingkang Wang, Yanan Zhou, Nannan Guo, Qi Liu, Shuyi Zong, Ying Bao, Hongxun Hao. (2016) Solid–liquid phase equilibrium and dissolution properties of ethyl vanillin in pure solvents. JOURNAL OF CHEMICAL THERMODYNAMICS, [PMID:] [10.1016/j.jct.2016.10.029] |
| 21. Jingying Pan, Jie Fu, Shuguang Deng, Xiuyang Lu. (2015) Distribution coefficient of products from lignin oxidative degradation in organic-water systems. FUEL PROCESSING TECHNOLOGY, [PMID:] [10.1016/j.fuproc.2015.09.016] |
| 22. Kissa R. Alunga, Yue-Yuan Ye, Shui-Rong Li, Duo Wang, Yun-Quan Liu. (2015) Catalytic oxidation of lignin–acetoderivatives: a potential new recovery route for value-added aromatic aldehydes from acetoderivatives. Catalysis Science & Technology, 5 (7): (3746-3753). [PMID:] [10.1039/C5CY00419E] |
| 23. Detao Li, Zichen Ning, Zhuoshan Gong, Limin Zhou, Li Xu, Feiqiang He, Hamza Shehzad, Heng Jerry, Shichao Du, Jinbo Ouyang. (2025) Insights into salts/cocrystals formation of polyhydroxy natural products as well as their separation behavior via cocrystallization. SEPARATION AND PURIFICATION TECHNOLOGY, [PMID:] [10.1016/j.seppur.2025.131453] |
| 24. Peng Qiannan, Zhao Cheng, Wang Xiaopeng, Cheng Kelin, Wang Congcong, Xu Xihui, Lin Lu. (2025) Modeling bacterial interactions uncovers the importance of outliers in the coastal lignin-degrading consortium. Nature Communications, 16 (1): (1-13). [PMID:39809803] [10.1038/s41467-025-56012-8] |
| 25. Hongyu Qu, Xiangcheng Li, Xiao Han, Junjie Li, Xinqiang Feng, Chuang Liu, Zhendong Wang, Weimin Yang. (2024) Ni-Supported Germanosilicate Zeolite SCM-14 for Efficient Hydrogenolysis of 5-Hydroxymethylfurfural to 2,5-Dimethylfuran. INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, [PMID:] [10.1021/acs.iecr.4c03041] |
| 26. Xuerui Lou, Minglei Li, Weiwei Guo, Yingjie Fu, Hui Xi, Peng Li, Wuduo Zhao, Shihao Sun. (2024) Rapid Determination of Flavorings in e-Cigarette Liquid by Direct Analysis in Real Time (DART) Mass Spectrometry (MS) in the Quick Strip Mode. ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2024.2308054] |
| 27. Zhang Hongtao, Gao Jiahui, Tan Lian, Zheng Li, Wang Longjie. (2024) Research on the Application of Terahertz Technology in Detecting Additives in Milk Powder. Food Analytical Methods, [PMID:] [10.1007/s12161-024-02720-8] |
| 28. Jun Wu, Liqian Liu, Xinyue Yan, Gang Pan, Jiahao Bai, Chengbing Wang, Fuwei Li, Yong Li. (2025) Microenvironment engineering of nitrogen-doped hollow carbon spheres encapsulated with Pd catalysts for highly selective hydrodeoxygenation of biomass-derived vanillin in water. CHINESE JOURNAL OF CATALYSIS, [PMID:] [10.1016/S1872-2067(24)60261-5] |
| 29. Zhenkun Mao, Changjun Hu, Zhentao Li, Zilin Chen. (2019) A reversed-phase/hydrophilic bifunctional interaction mixed-mode monolithic column with biphenyl and quaternary ammonium stationary phases for capillary electrochromatography. ANALYST, 144 (14): (4386-4394). [PMID:31210197] [10.1039/C9AN00428A] |
| 30. Qunfeng Chen, Daobin Tang, Qi Zhang, Zhiyuan Tang, Longlong Ma, Xinghua Zhang. (2025) Electron-metal support interactions enhanced by W-O-Zr interface in Pd-UiO-66 catalyst for efficient HDO of lignin derivatives at room temperature. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.163903] |
| 31. Feng He, Lingling Guo, Liqiang Liu, Xinxin Xu, Liguang Xu, Chuanlai Xu, Hua Kuang, Maozhong Sun. (2025) Highly Specific Monoclonal Antibodies Combined with A Multiplex Quantum Dot Microsphere-based Fluorescence Lateral Flow Immunochromatographic Assay for Simultaneous Detection of Vanillin, Methyl Vanillin, and Ethyl Vanillin in Food Samples. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:41147867] [10.1021/acs.jafc.5c09933] |
| 32. Tianyin Huang, Yifan Yu, Wentao Zhang, Yue Zhao, Yiliang Tao, Wenguang Huang, Bingdang Wu. (2026) Molecular orbital-guided design of laccase–mediator systems for antibiotic removal in the presence of humic acid. BIORESOURCE TECHNOLOGY, [PMID:41513177] [10.1016/j.biortech.2026.133957] |
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