3-Bromo-4-fluoroaniline HCl: Properties, Uses & Handling FAQ

3-Bromo-4-fluoroaniline, HCl is a halogenated aromatic amine hydrochloride salt widely used as a versatile building block in pharmaceutical synthesis, agrochemical research, and medicinal chemistry programs.

Product Name

3-Bromo-4-fluoroaniline, HCl

SKU

B180723

Molecular Formula (free base)

C₆H₅BrFN · HCl

Form

Hydrochloride salt (solid)

Key Functional Groups

Primary amine (–NH₂), aryl bromide, aryl fluoride

Primary Application

Pharmaceutical and agrochemical intermediate; medicinal chemistry building block

Chemical Identity and Structure

3-Bromo-4-fluoroaniline, HCl (SKU: B180723) is the hydrochloride salt of 3-bromo-4-fluoroaniline, a substituted aromatic amine bearing both a bromine atom at the 3-position and a fluorine atom at the 4-position of the aniline ring. The salt form improves the compound's stability and handling characteristics compared with the free base, which can be sensitive to air and moisture. The primary amine nitrogen is protonated in the HCl salt form, rendering the compound less volatile and generally easier to weigh and handle on the bench. The free base can be liberated by treatment with a mild aqueous base prior to use in reactions requiring the neutral amine.

Synthetic and Research Applications

3-Bromo-4-fluoroaniline, HCl is a multifunctional building block exploited across several areas of synthetic chemistry. The aryl bromide handle is well-suited to palladium-catalysed cross-coupling reactions, including Suzuki–Miyaura, Buchwald–Hartwig, and Sonogashira couplings, allowing rapid diversification of the aromatic scaffold. The aryl fluorine substituent can participate in nucleophilic aromatic substitution (SNAr) under appropriate conditions or serve as a metabolic-stability-enhancing element in drug candidates. The free amine (released from the HCl salt) can undergo acylation, sulfonylation, reductive amination, and diazotisation, providing broad access to amides, sulfonamides, secondary amines, and diazonium-derived products. These combined handles make the compound particularly attractive for the synthesis of kinase inhibitors, antimicrobial agents, and other bioactive small molecules.

Storage, Stability, and Handling

As a hydrochloride salt of a primary aromatic amine, 3-Bromo-4-fluoroaniline, HCl should be stored in a tightly sealed container away from light, heat, and moisture. Cool, dry conditions (typically 2–8 °C or as specified on the product label) are recommended to maximise shelf life. Upon opening, the container should be re-sealed promptly and the compound used within a reasonable period. Standard personal protective equipment—laboratory coat, nitrile gloves, and safety spectacles—should be worn at all times when handling this material. Work should be conducted in a well-ventilated fume hood. Users should consult the Safety Data Sheet (SDS) for full hazard classification, first-aid measures, and disposal guidance before use.

Purity, Specifications, and Quality

Aladdin Scientific supplies 3-Bromo-4-fluoroaniline, HCl (B180723) as a research-grade reagent. Lot-specific purity data and analytical certificates (Certificates of Analysis, CoA) are available upon request or via the Aladdin website using the batch number printed on the label. Common analytical methods used to characterise this compound include HPLC for purity determination and NMR spectroscopy for structural confirmation. Researchers requiring higher purity grades or custom pack sizes should contact Aladdin's technical or sales team directly. Always verify the CoA data matches your experimental requirements before committing the material to a critical synthesis step.

Ordering and Availability

3-Bromo-4-fluoroaniline, HCl is available from Aladdin Scientific under SKU B180723. To place an order, visit the Aladdin website, search by SKU or product name, and add the desired quantity to your cart. Bulk quantities, custom packaging, and institutional purchase orders can be arranged by contacting the Aladdin sales team. For questions about pricing, lead times, or availability in your region, please reach out through the website's inquiry form or customer service channels. Reward points and promotional discounts may apply; check current promotions on the Aladdin website at the time of purchase.

Frequently asked questions

What is 3-Bromo-4-fluoroaniline, HCl used for in organic synthesis?

3-Bromo-4-fluoroaniline, HCl serves as a versatile bifunctional building block. The aryl bromide enables palladium-catalysed cross-coupling reactions (e.g., Suzuki, Buchwald–Hartwig, Sonogashira), while the free amine (released from the HCl salt) supports acylation, sulfonylation, and diazotisation. The aryl fluoride can participate in SNAr reactions or confer metabolic stability to drug candidates.

How should I convert the HCl salt to the free base aniline before a reaction?

To liberate the free base, dissolve the HCl salt in water or a suitable aqueous–organic mixture and treat with a mild inorganic base such as aqueous sodium carbonate, sodium bicarbonate, or dilute sodium hydroxide until the solution is basic (pH > 9). Extract the free amine into an organic solvent (e.g., ethyl acetate or dichloromethane), dry over anhydrous sodium sulfate or magnesium sulfate, filter, and concentrate. Use the free base promptly, as aromatic primary amines can be sensitive to oxidation on prolonged exposure to air.

What storage conditions are recommended for B180723?

Store 3-Bromo-4-fluoroaniline, HCl in a tightly sealed container under cool, dry, and dark conditions—typically at 2–8 °C or as specified on the product label and Certificate of Analysis. Protect from moisture and avoid prolonged exposure to light or elevated temperatures. Always re-seal the container promptly after use to maintain product integrity.

Is a Certificate of Analysis (CoA) available for 3-Bromo-4-fluoroaniline, HCl?

Yes. Lot-specific Certificates of Analysis for B180723 are available through the Aladdin Scientific website by entering the batch number, or by contacting Aladdin's customer service team directly. The CoA typically includes purity data and key characterisation information for the specific lot supplied.

What safety precautions should I follow when handling this compound?

Wear appropriate personal protective equipment including a laboratory coat, nitrile gloves, and safety glasses. Handle the compound in a well-ventilated fume hood to minimise inhalation exposure. Consult the Safety Data Sheet (SDS) for B180723 for full hazard classification, exposure limits, first-aid measures, and disposal requirements before use. Avoid contact with skin, eyes, and clothing.

References

1. Aladdin Scientific product page for 3-Bromo-4-fluoroaniline, HCl, SKU B180723.
2. March, J. Advanced Organic Chemistry: Reactions, Mechanisms, and Structure, 4th ed.; Wiley: New York, 1992. (General reference for cross-coupling and amine chemistry.)
3. Roughley, S. D.; Jordan, A. M. The medicinal chemist's toolbox: An analysis of reactions used in the pursuit of drug candidates. J. Med. Chem. 2011, 54, 3451–3479. doi:10.1021/jm200187y

Products are supplied for research and development use only. Not for use in humans, animals, diagnosis, or therapy.