Microfilaments are mainly formed by the polymerization of actin and are an important component of the cytoskeleton. They participate in the maintenance of cell morphology, adhesion and migration, cytokinesis, endocytic transport, stress fiber formation, and the establishment of cell polarity.
The uPA/uPAR system is not merely a proteolytic module, but an important interface linking local fibrinolytic activation, cell-adhesion switching, amplification of migratory signaling, and microenvironment remodeling.
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